⊟Summary[edit | edit source]
- pan ID?: SAUPAN005401000
- symbol?: atpI
- synonym:
- description?: ATP synthase
- ATP synthase
- ATP synthase protein I, putative
- ATP synthase subunit I
- ATP synthase I
- ATP synthase I, AtpI
- ATP synthase I chain family protein
- putative ATP synthase protein I
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 5562171..5562524
- synteny block?: BlockID0041970
- occurrence?: in 97% of 34 strains
atpI : F0F1 ATP synthase subunit I [1]
ATP synthases couple proton translocation across membranes to rotational energy, conformational change and, ultimately, ATP generation. The F0 portion is a multimeric membrane-embedded proton channel (ab2c10) while the F1 portion is a multimeric cytoplasmic structure (α3β3γδε) that binds ADP and phosphate. When necessary, this process can also be run in reverse to generate a proton gradient at the expense of ATP. AtpI encodes F0 subunit I, a chaperone-like protein that can assist in proper assembly of the F0 C-ring flywheel. However, AtpI is not essential in all systems or under all conditions for proper F0F1 ATPase assembly while some non-staphylococcal organisms also require other specialized chaperones (e.g. AtpZ) or alternative chaperones (e.g. YidC/OxaI/Alb3).
⊟Orthologs[edit | edit source]
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL ---------------------------------MSRFYNIFKQFIQYYFYLIIILGGLYL
N315 ---------------------------------MSRFYNIFKQFIQYYFYLIIILGGLYL
NCTC8325 MNRIDTTNRLYYHLVCMSGTVFMIDISHTEAYKMSRFYNIFKQFIQYYFYLIIILGGLYL
Newman ---------------------------------MSRFYNIFKQFIQYYFYLIIILGGLYL
***************************
COL YTHHAFILGLIIGVTGSAINTCIFECYLAKAKRPDTMHISTGNMWRYLVAIIACMIWYLN
N315 YTHHAFILGLIIGVTGSAINTCIFECYLAKAKRPDTMHISTGNMWRYLVAIIACMIWYLN
NCTC8325 YTHHAFILGLIIGVTGSAINTCIFECYLAKAKRPDTMHISTGNMWRYLVAIIACMIWYLN
Newman YTHHAFILGLIIGVTGSAINTCIFECYLAKAKRPDTMHISTGNMWRYLVAIIACMIWYLN
************************************************************
COL KAHVSIIGIIIGLMISYVVVIIRPLLKVSK
N315 KAHVSIIGIIIGLMISYVVVIIRPLLKVSK
NCTC8325 KAHVSIIGIIIGLMISYVVVIIRPLLKVSK
Newman KAHVSIIGIIIGLMISYVVVIIRPLLKVSK
******************************
- ↑ G Deckers-Hebestreit, K Altendorf
The F0F1-type ATP synthases of bacteria: structure and function of the F0 complex.
Annu Rev Microbiol: 1996, 50;791-824
[PubMed:8905099] [WorldCat.org] [DOI] (P p)Jun Liu, David B Hicks, Terry A Krulwich
Roles of AtpI and two YidC-type proteins from alkaliphilic Bacillus pseudofirmus OF4 in ATP synthase assembly and nonfermentative growth.
J Bacteriol: 2013, 195(2);220-30
[PubMed:23123906] [WorldCat.org] [DOI] (I p)Martin Vestergaard, Sahar Roshanak, Hanne Ingmer
Targeting the ATP Synthase in Staphylococcus aureus Small Colony Variants, Streptococcus pyogenes and Pathogenic Fungi.
Antibiotics (Basel): 2021, 10(4);
[PubMed:33918382] [WorldCat.org] [DOI] (P e)