⊟Summary[edit | edit source]
- pan ID?: SAUPAN005399000
- symbol?: atpE
- synonym:
- description?: F0F1 ATP synthase subunit C
- F0F1 ATP synthase subunit C
- ATP synthase subunit C
- ATP synthase F0F1 subunit C
- ATP synthase FO, subunit C
- ATP synthase C chain
- ATP synthase F0, C subunit
- ATP synthase F0 subunit C
- ATP synthase subunit C, AtpC
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 5561166..5561378
- synteny block?: BlockID0041950
- occurrence?: in 100% of 34 strains
atpE : F0F1 ATP synthase subunit C [1]
ATP synthases couple proton translocation across membranes to rotational energy, conformational change and, ultimately, ATP generation. The F0 portion is a multimeric membrane-embedded proton channel (ab2c10) while the F1 portion is a multimeric cytoplasmic structure (α3β3γδε) that binds ADP and phosphate. When necessary, this process can also be run in reverse to generate a proton gradient at the expense of ATP. AtpE encodes F0 subunit C, the monomer that oligomerizes with ~10 subunits into the F0 C-ring flywheel. Inward-facing aspartate residues associate with protons traveling through the proton channel stator and couple that association to rotational conformational changes.
⊟Orthologs[edit | edit source]
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MNLIAAAIAIGLSALGAGIGNGLIVSRTVEGVARQPEARGQLMGIMFIGVGLVEALPIIG
N315 MNLIAAAIAIGLSALGAGIGNGLIVSRTVEGVARQPEARGQLMGIMFIGVGLVEALPIIG
NCTC8325 MNLIAAAIAIGLSALGAGIGNGLIVSRTVEGVARQPEARGQLMGIMFIGVGLVEALPIIG
Newman MNLIAAAIAIGLSALGAGIGNGLIVSRTVEGVARQPEARGQLMGIMFIGVGLVEALPIIG
USA300_FPR3757 MNLIAAAIAIGLSALGAGIGNGLIVSRTVEGVARQPEARGQLMGIMFIGVGLVEALPIIG
************************************************************
COL VVIAFMTFAG
N315 VVIAFMTFAG
NCTC8325 VVIAFMTFAG
Newman VVIAFMTFAG
USA300_FPR3757 VVIAFMTFAG
**********
- ↑ G Deckers-Hebestreit, K Altendorf
The F0F1-type ATP synthases of bacteria: structure and function of the F0 complex.
Annu Rev Microbiol: 1996, 50;791-824
[PubMed:8905099] [WorldCat.org] [DOI] (P p)Martin Vestergaard, Sahar Roshanak, Hanne Ingmer
Targeting the ATP Synthase in Staphylococcus aureus Small Colony Variants, Streptococcus pyogenes and Pathogenic Fungi.
Antibiotics (Basel): 2021, 10(4);
[PubMed:33918382] [WorldCat.org] [DOI] (P e)