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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005188000
- symbol?: int3
- synonym:
- description?: integrase
- integrase
- site-specific integrase
- phage integrase
- bacteriophage integrase
- DNA integration/recombination/inversion protein
- Integrase, phage associated
- phage integrase family protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 5356471..5357532
- synteny block?: BlockID0040200
- occurrence?: in 68% of 34 strains
intφSa3 (int3) : beta-hemolysin-converting prophage site-specific integrase Sa3int [1]
This prophage integrase catalyzes insertion of prophages at the consensus attB sequence TGTATCCGAATTGG within beta hemolysin located between mapW and lukG. Sa3int prophages typically carry the immune evasion cluster and increase the virulence of their host strains. Sa3int prophage are found in up to 95% of human invasive isolates but are less prevalent in nasal colonization isolates or invasive isolates from animal hosts. This integrase can also catalyze insertion into degenerate sites resembling the consensus attB sequence within such genes as ebh.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1964
08BA02176:
—
11819-97:
MS7_2034
6850:
—
71193:
ST398NM01_0469
ECT-R 2:
ECTR2_1874
ED133:
—
ED98:
SAAV_2070
HO 5096 0412:
SAEMRSA15_19260 (int)
JH1:
SaurJH1_2097
JH9:
SaurJH9_2060
JKD6008:
SAA6008_02056
JKD6159:
SAA6159_01937
JSNZ:
—
LGA251:
—
M013:
—
MRSA252:
SAR2105 (int)
MSHR1132:
SAMSHR1132_18450
MSSA476:
SAS1922
Mu3:
SAHV_1988 (int)
Mu50:
SAV2002 (int)
MW2:
MW1939 (int)
RF122:
—
ST398:
—
T0131:
SAT0131_02138
TCH60:
—
TW20:
SATW20_20000 (int)
USA300_TCH1516:
USA300HOU_2009 (int)
VC40:
—
⊟Genome Viewer[edit | edit source]
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
N315 --------MKTRCYDGKKWQYEFKHEGKRYRKKGFRTKREANSAGLDKLNELRSGFNIDN
NCTC8325 --------MKTRCYDGKKWQYEFKHEGKRYRKKGFRTKREANSAGLDKLNELRSGFNIDN
Newman MPILRRERMKTRCYDGKKWQYEFKHEGKRYRKKGFRTKREANSAGLDKLNELRSGFNIDN
USA300_FPR3757 --------MKTRCYDGKKWQYEFKYEGKRYRKKGFRTKREANSAGLDKLNELRSGFNIDN
****************:***********************************
N315 YITLEEYFENWIKTYKQPVVKENTYRHYRNALQHIQKHKIGKMELSKINRQVYQKFINDH
NCTC8325 YITLAEYFENWIKTYKQPVVKENTYRHYRNALQHIQKHKIGKMELSKINRQVYQKFINDY
Newman YITLEEYFENWIKTYKQPVVKENTYRHYRNALQHIQKHKIGKMELSKINRQVYQKFINDY
USA300_FPR3757 YITLEEYFENWIKTYKQPVVKENTYRHYRNALQHIQKHKIGKMELSKINRQVYQKFINDY
**** ******************************************************:
N315 SKEHAKETIRKTNGAIRSALDDALYDGLIFKNPAYKVNYKAGKPTKSEQEKFISVTEYEI
NCTC8325 SKEHAKETIRKTNGAIRSALDDALYDGLIFKNPAYKVNYKAGKPTKSEQEKFISVTEYEI
Newman SKEHAKETIRKTNGAIRSALDDALYDGLIFKNPAYKVNYKAGKPTKSEQEKFISVTEYEI
USA300_FPR3757 SKEHAKETIRKTNGAIRSALDDALYDGLIFKNPAYKVNYKAGKPTKSEQEKFISVTEYEI
************************************************************
N315 LKDHVRKKRTRSSLALFIMICTGCRVSGARNIKIEHINQVKNTIFIDERKTDTSPRYISI
NCTC8325 LKDHVRKKRTRSSLALFIMICTGCRVSGARNIKIEHINQVKNTIFIDERKTDTSPRYISI
Newman LKDHVRKKRTRSSLALFIMICTGCRVSGARNIKIEHINQVKNTIFIDERKTNTSPRYISI
USA300_FPR3757 LKDHVRKKRTRSSLALFIMICTGCRVSGARNIKIEHINQVKNTIFIDERKTDTSPRYISI
***************************************************:********
N315 AKSDMKHIMDVISTFAISYDGYIFKEAGSIINLQAINNALKSACRVNNIPIITSHALRHT
NCTC8325 AKSDMKHIMDVISTFAISYDGYIFKEAGSIINLQAINNALKSACRVNNIPIITSHALRHT
Newman AKSDMKHIMDVISTFAISYDGYIFKEGGSIINLHAINNALKSACRVNNIPIITSHALRHT
USA300_FPR3757 AKSDMKHIMDVISTFAISYDGYIFKEAGSIINLHAINNALKSACRVNNISIITSHALRHT
**************************.******:***************.**********
N315 HCSYLLAKGVSIHYISKRLGHKNIAITTSVYSHLLEEKFNEEDKKTTKILESM
NCTC8325 HCSYLLAKGVSIHYISKRLGHKNIAITTSVYSHLLEEKFNEEDKKTTKILESM
Newman HCSYLLAKGVSIHYISKRLGHKNIAITTSVYSHLLEEKFNEEDKKTTKILESM
USA300_FPR3757 HCSYLLAKGVSIHYISKRLGHKNIAITTSVYSHLLEEKFNEEDKKTTKILESM
*****************************************************
- ↑ Christiane Goerke, Roman Pantucek, Silva Holtfreter, Berit Schulte, Manuel Zink, Dorothee Grumann, Barbara M Bröker, Jiri Doskar, Christiane Wolz
Diversity of prophages in dominant Staphylococcus aureus clonal lineages.
J Bacteriol: 2009, 191(11);3462-8
[PubMed:19329640] [WorldCat.org] [DOI] (I p)Helena Leinweber, Raphael N Sieber, Jesper Larsen, Marc Stegger, Hanne Ingmer
Staphylococcal Phages Adapt to New Hosts by Extensive Attachment Site Variability.
mBio: 2021, 12(6);e0225921
[PubMed:34872344] [WorldCat.org] [DOI] (I p)