⊟Summary[edit | edit source]
- pan ID?: SAUPAN005129000
- symbol?: —
- synonym:
- description?: phage protein
- strand?: -
- coordinates?: 5265979..5266522
- synteny block?: BlockID0039810
- occurrence?: in 18% of 34 strains
tmcT : prophage type I addiction module toxin TmcT [1]
Staphylococcal toxin-antitoxin systems provide a mechanism to rapidly alter growth rates under changing environmental stresses. TmcT is a DUF2829 (SA1803) family toxin thought to inhibit membrane translocation systems including type VII secretion systems, NorA pumps and monovalent cation antiporters resulting in bacteriostasis and persistence. It is sequestered by the RNA antitoxin TmcA. Although not often identified on initial annotations, TmcT is actually present in several prophage genomes including USA300_FPR3757. The TmcTA module appears to have integrated into a recombination hotspot distal to the prophage φ12-like mor regulator, replacing the n32 core sequence in: ACAAACA - n32 - ACAAACA
⊟Orthologs[edit | edit source]
⊟Genome Viewer[edit | edit source]
⊟Alignments[edit | edit source]
- alignment of orthologues:
- ↑ Gul Habib, Jiade Zhu, Baolin Sun
A novel type I toxin-antitoxin system modulates persister cell formation in Staphylococcus aureus.
Int J Med Microbiol: 2020, 310(2);151400
[PubMed:32001143] [WorldCat.org] [DOI] (I p)