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⊟Summary[edit | edit source]
- pan ID?: SAUPAN004566000
- symbol?: splB
- synonym:
- description?: serine protease SplB
- serine protease SplB
- serine protease
- peptidase S1 and S6, chymotrypsin/Hap
- peptidase S1 and S6 chymotrypsin/Hap
- serine proteinase
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4801491..4802213
- synteny block?: BlockID0035550
- occurrence?: in 71% of 34 strains
splB : staphylococcal serine protease SplB [1]
• A crystal structure is available : 2VID
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1767 (splB)
08BA02176:
—
11819-97:
MS7_1813 (splB)
6850:
RSAU_001669 (splB)
71193:
—
ECT-R 2:
ECTR2_1644
ED133:
SAOV_1797
ED98:
SAAV_1820 (splB)
HO 5096 0412:
—
JH1:
SaurJH1_1898
JH9:
SaurJH9_1863
JKD6008:
—
JKD6159:
—
JSNZ:
JSNZ_001810 (splB)
LGA251:
SARLGA251_16960 (splB)
M013:
—
MRSA252:
—
MSHR1132:
—
MSSA476:
SAS1735
Mu3:
SAHV_1797 (splB)
Mu50:
SAV1812 (splB)
MW2:
MW1754 (splB)
RF122:
SAB1672c
ST398:
—
T0131:
SAT0131_01932
TCH60:
—
TW20:
SATW20_18100 (splB)
USA300_TCH1516:
USA300HOU_1805 (splB)
VC40:
SAVC_08300
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MNKNVVIKSLAALTILTSVTGIGTTLVEEVQQTAKAENNVTKVKDTNIFPYTGVVAFKSA
N315 MNKNVVIKSLATLTILTSVTGIGTTLVEEVQQTAKAENNVTKIQDTNIFPYTGVVAFKSA
NCTC8325 MNKNVVIKSLAALTILTSVTGIGTTLVEEVQQTAKAENNVTKVKDTNIFPYTGVVAFKSA
Newman MNKNVVIKSLAALTILTSVTGIGTTLVEEVQQTAKAENNVTKVKDTNIFPYTGVVAFKSA
USA300_FPR3757 MNKNVVIKSLAALTILTSVTGIGTTLVEEVQQTAKAENNVTKVKDTNIFPYTGVVAFKSA
***********:******************************::****************
COL TGFVVGKNTILTNKHVSKNYKVGDRITAHPNSDKGNGGIYSIKKIINYPGKEDVSVIQVE
N315 TGFVVGKNTILTNKHVSKNYKVGDRITAHPNSDKGNGGIYSIKKIINYPGKEDVSVIQVE
NCTC8325 TGFVVGKNTILTNKHVSKNYKVGDRITAHPNSDKGNGGIYSIKKIINYPGKEDVSVIQVE
Newman TGFVVGKNTILTNKHVSKNYKVGDRITAHPNSDKGNGGIYSIKKIINYPGKEDVSVIQVE
USA300_FPR3757 TGFVVGKNTILTNKHVSKNYKVGDRITAHPNSDKGNGGIYSIKKIINYPGKEDVSVIQVE
************************************************************
COL ERAIERGPKGFNFNDNVTPFKYAAGAKAGERIKVIGYPHPYKNKYVLYESTGPVMSVEGS
N315 ERAIERGPKGFNFNDNVTPFKYAAGAKAGERIKVIGYPHPYKNKYVLYESTGPVMSVEGS
NCTC8325 ERAIERGPKGFNFNDNVTPFKYAAGAKAGERIKVIGYPHPYKNKYVLYESTGPVMSVEGS
Newman ERAIERGPKGFNFNDNVTPFKYAAGAKAGERIKVIGYPHPYKNKYVLYESTGPVMSVEGS
USA300_FPR3757 ERAIERGPKGFNFNDNVTPFKYAAGAKAGERIKVIGYPHPYKNKYVLYESTGPVMSVEGS
************************************************************
COL SIVYSAHTESGNSGSPVLNSNNELVGIHFASDVKNDDNRNAYGVYFTPEIKKFIAENIDK
N315 SIVYSAHTESGNSGSPVLNSNNELVGIHFASDVKNDDNRNAYGVYFTPEIKKFIAENIDK
NCTC8325 SIVYSAHTESGNSGSPVLNSNNELVGIHFASDVKNDDNRNAYGVYFTPEIKKFIAENIDK
Newman SIVYSAHTESGNSGSPVLNSNNELVGIHFASDVKNDDNRNAYGVYFTPEIKKFIAENIDK
USA300_FPR3757 SIVYSAHTESGNSGSPVLNSNNELVGIHFASDVKNDDNRNAYGVYFTPEIKKFIAENIDK
************************************************************
- ↑ Grzegorz M Popowicz, Grzegorz Dubin, Justyna Stec-Niemczyk, Anna Czarny, Adam Dubin, Jan Potempa, Tad A Holak
Functional and structural characterization of Spl proteases from Staphylococcus aureus.
J Mol Biol: 2006, 358(1);270-9
[PubMed:16516230] [WorldCat.org] [DOI] (P p)Prasad Dasari, Maria Nordengrün, Cláudia Vilhena, Leif Steil, Goran Abdurrahman, Kristin Surmann, Vishnu Dhople, Julia Lahrberg, Claus Bachert, Christine Skerka, Uwe Völker, Barbara M Bröker, Peter F Zipfel
The Protease SplB of Staphylococcus aureus Targets Host Complement Components and Inhibits Complement-Mediated Bacterial Opsonophagocytosis.
J Bacteriol: 2022, 204(1);e0018421
[PubMed:34633872] [WorldCat.org] [DOI] (I p)