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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003709000
- symbol?: rpsN2
- synonym:
- description?: 30S ribosomal protein S14
- 30S ribosomal protein S14
- 30S ribosomal protein S14p
- alternate 30S ribosomal protein S14
- ribosomal protein S14p/S29e family protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 4013743..4014012
- synteny block?: BlockID0027750
- occurrence?: in 97% of 34 strains
rpsN2 : 30S ribosomal protein S14 paralogue [1]
Staphylococci have two copies of rpsN. rpsN is the "type Z" version found in a large operon of ribosomal proteins while rpsN2 is next to the gene encoding guanosine monophosphate reductase and lacks the canonical CXXC zinc binding motif required for a functional 30S ribosome. Considering the low full-length identity, dissimilar N-termini, the loss of zinc binding motifs and the essentiality of rpsN (but not rpsN2), it is unclear if rpsN2 still performs any analogous function to "type Z" ribosomal rpsN.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1291 (rpsN)
08BA02176:
C248_1372
11819-97:
MS7_1295 (rpsN2)
6850:
RSAU_001218 (rpsN1)
71193:
ST398NM01_1338
ECT-R 2:
ECTR2_1195
ED133:
SAOV_1349 (rpsN)
ED98:
SAAV_1316 (rpsN)
HO 5096 0412:
SAEMRSA15_11830
JH1:
SaurJH1_1424 (rpsN)
JH9:
SaurJH9_1397 (rpsN)
JKD6008:
SAA6008_01302 (rpsN_1)
JKD6159:
SAA6159_01203 (rpsN_1)
JSNZ:
JSNZ_001320 (rpsN)
LGA251:
SARLGA251_12450
M013:
M013TW_1284
MRSA252:
SAR1346 (rpsN)
MSHR1132:
SAMSHR1132_11810
MSSA476:
SAS1276 (rpsN)
Mu3:
SAHV_1325 (rpsN)
Mu50:
SAV1336 (rpsN)
MW2:
MW1223 (rpsN)
RF122:
SAB1194 (rpsN)
ST398:
SAPIG1338
T0131:
SAT0131_01407
TCH60:
HMPREF0772_11872 (rpsN2)
TW20:
SATW20_13380
USA300_TCH1516:
—
VC40:
SAVC_05920 (rpsN)
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MAKKSKIAKERKREELVNKYYELRKELKAKGDYEALRKLPRDSSPTRLTRRCKVTGRPRG
N315 MAKKSKIAKERKREELVNKYYELRKELKAKGDYEALRKLPRDSSPTRLTRRCKVTGRPRG
NCTC8325 MAKKSKIAKERKREELVNKYYELRKELKAKGDYEALRKLPRDSSPTRLTRRCKVTGRPRG
Newman MAKKSKIAKERKREELVNKYYELRKELKAKGDYEALRKLPRDSSPTRLTRRCKVTGRPRG
USA300_FPR3757 MAKKSKIAKERKREELVNKYYELRKELKAKGDYEALRKLPRDSSPTRLTRRCKVTGRPRG
************************************************************
COL VLRKFEMSRIAFREHAHKGQIPGVKKSSW
N315 VLRKFEMSRIAFREHAHKGQIPGVKKSSW
NCTC8325 VLRKFEMSRIAFREHAHKGQIPGVKKSSW
Newman VLRKFEMSRIAFREHAHKGQIPGVKKSSW
USA300_FPR3757 VLRKFEMSRIAFREHAHKGQIPGVKKSSW
*****************************
- ↑ Alexander Golubev, Bulat Fatkhullin, Iskander Khusainov, Lasse Jenner, Azat Gabdulkhakov, Shamil Validov, Gulnara Yusupova, Marat Yusupov, Konstantin Usachev
Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 Å resolution.
FEBS Lett: 2020, 594(21);3551-3567
[PubMed:32852796] [WorldCat.org] [DOI] (I p)