⊟Summary[edit | edit source]

pan ID^?: SAUPAN003168000
symbol^?: trfA
synonym:
description^?: adaptor protein MecA
- adaptor protein MecA
- adaptor protein
- negative regulator of genetic competence, putative
- adapter protein mecA
- Negative regulator of genetic competence MecA
- genetic competence repressor
- negative regulator of genetic competence (MecA) family protein
- negative regulator of genetic competence family protein
- putative negative regulator of genetic competence
- regulatory protein
strand^?: +
coordinates^?: 3561029..3561748
synteny block^?: BlockID0022550
occurrence^?: in 100% of 34 strains

trfA (mecA): ClpCP substrate-recognition adaptor protein ^[1]

TrfA-augmented ClpCP is efficient at proteolyzing ssrA-tagged proteins and antitoxins from Type II toxin-antitoxin systems. TrfA has complex temporal expression and is further modulated by Spx levels.

⊟Orthologs[edit | edit source]

COL:

N315:

NCTC8325:

Newman:

USA300_FPR3757:

JSNZ:

JSNZ_000958 (mecA)

04-02981:

SA2981_0953

08BA02176:

C248_1021

11819-97:

MS7_0954

6850:

RSAU_000874

71193:

ST398NM01_0994

ECT-R 2:

ECTR2_853

ED133:

SAOV_0944

ED98:

SAAV_0961

HO 5096 0412:

SAEMRSA15_08290

JH1:

SaurJH1_1016

JH9:

SaurJH9_0997

JKD6008:

SAA6008_00951 (mecA2)

JKD6159:

SAA6159_00855 (mecA2)

LGA251:

SARLGA251_09140

M013:

M013TW_0921

MRSA252:

SAR0966

MSHR1132:

SAMSHR1132_08460

MSSA476:

SAS0868

Mu3:

SAHV_0993

Mu50:

SAV0998

MW2:

MW0880

RF122:

SAB0865

ST398:

SAPIG0994

T0131:

SAT0131_01033

TCH60:

HMPREF0772_12238 (mecA2)

TW20:

SATW20_09960

USA300_TCH1516:

USA300HOU_0956 (mecA2)

VC40:

SAVC_04160

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.307)

COL             MRIERVDDTTVKLFITYSDIEARGFSREDLWTNRKRGEEFFWSMMDEINEEEDFVVEGPL
N315            MRIERVDDTTVKLFITYSDIEARGFSREDLWTNRKRGEEFFWSMMDEINEEEDFVVEGPL
NCTC8325        MRIERVDDTTVKLFITYSDIEARGFSREDLWTNRKRGEEFFWSMMDEINEEEDFVVEGPL
Newman          MRIERVDDTTVKLFITYSDIEARGFSREDLWTNRKRGEEFFWSMMDEINEEEDFVVEGPL
USA300_FPR3757  MRIERVDDTTVKLFITYSDIEARGFSREDLWTNRKRGEEFFWSMMDEINEEEDFVVEGPL
                ************************************************************

COL             WIQVHAFDKGVEVTISKSKNEDMMNMSDDDATDQFDEQVQELLAQTLEGEDQLEELFEQR
N315            WIQVHAFEKGVEVTISKSKNEDMMNMSDDDATDQFDEQVQELLAQTLEGEDQLEELFEQR
NCTC8325        WIQVHAFEKGVEVTISKSKNEDMMNMSDDDATDQFDEQVQELLAQTLEGEDQLEELFEQR
Newman          WIQVHAFEKGVEVTISKSKNEDMMNMSDDDATDQFDEQVQELLAQTLEGEDQLEELFEQR
USA300_FPR3757  WIQVHAFEKGVEVTISKSKNEDMMNMSDDDATDQFDEQVQELLAQTLEGEDQLEELFEQR
                *******:****************************************************

COL             TKEKEAQGSKRQKSSARKNTRTIIVKFNDLEDVINYAYHSNPITTEFEDLLYMVDGTYYY
N315            TKEKEAQGSKRQKSSARKNTRTIIVKFNDLEDVINYAYHSNPITTEFEDLLYMVDGTYYY
NCTC8325        TKEKEAQGSKRQKSSARKNTRTIIVKFNDLEDVINYAYHSNPITTEFEDLLYMVDGTYYY
Newman          TKEKEAQGSKRQKSSARKNTRTIIVKFNDLEDVINYAYHSNPITTEFEDLLYMVDGTYYY
USA300_FPR3757  TKEKEAQGSKRQKSSARKNTRTIIVKFNDLEDVINYAYHSNPITTEFEDLLYMVDGTYYY
                ************************************************************

COL             AVYFDSHVDQEVINDSYSQLLEFAYPTDRTEVYLNDYAKIIMSHNVTAQVRRYFPETTE
N315            AVHFDSHVDQEVINDSYSQLLEFAYPTDRTEVYLNDYAKIIMSHNVTAQVRRYFPETTE
NCTC8325        AVYFDSHVDQEVINDSYSQLLEFAYPTDRTEVYLNDYAKIIMSHNVTAQVRRYFPETTE
Newman          AVYFDSHVDQEVINDSYSQLLEFAYPTDRTEVYLNDYAKIIMSHNVTAQVRRYFPETTE
USA300_FPR3757  AVYFDSHVDQEVINDSYSQLLEFAYPTDRTEVYLNDYAKIIMSHNVTAQVRRYFPETTE
                **:********************************************************

↑ Niles P Donegan, Jonathan S Marvin, Ambrose L Cheung
Role of adaptor TrfA and ClpPC in controlling levels of SsrA-tagged proteins and antitoxins in Staphylococcus aureus.
J Bacteriol: 2014, 196(23);4140-51
[PubMed:25225270] [WorldCat.org] [DOI] (I p)Adriana Renzoni, William L Kelley, Christine Barras, Antoinette Monod, Elzbieta Huggler, Patrice François, Jacques Schrenzel, René Studer, Pierre Vaudaux, Daniel P Lew
Identification by genomic and genetic analysis of two new genes playing a key role in intermediate glycopeptide resistance in Staphylococcus aureus.
Antimicrob Agents Chemother: 2009, 53(3);903-11
[PubMed:19104009] [WorldCat.org] [DOI] (I p)Olesya O Panasenko, Fedor Bezrukov, Olga Komarynets, Adriana Renzoni
YjbH Solubility Controls Spx in Staphylococcus aureus: Implication for MazEF Toxin-Antitoxin System Regulation.
Front Microbiol: 2020, 11;113
[PubMed:32117138] [WorldCat.org] [DOI] (P e)

[1] Niles P Donegan, Jonathan S Marvin, Ambrose L Cheung
Role of adaptor TrfA and ClpPC in controlling levels of SsrA-tagged proteins and antitoxins in Staphylococcus aureus.
J Bacteriol: 2014, 196(23);4140-51
[PubMed:25225270] [WorldCat.org] [DOI] (I p)Adriana Renzoni, William L Kelley, Christine Barras, Antoinette Monod, Elzbieta Huggler, Patrice François, Jacques Schrenzel, René Studer, Pierre Vaudaux, Daniel P Lew
Identification by genomic and genetic analysis of two new genes playing a key role in intermediate glycopeptide resistance in Staphylococcus aureus.
Antimicrob Agents Chemother: 2009, 53(3);903-11
[PubMed:19104009] [WorldCat.org] [DOI] (I p)Olesya O Panasenko, Fedor Bezrukov, Olga Komarynets, Adriana Renzoni
YjbH Solubility Controls Spx in Staphylococcus aureus: Implication for MazEF Toxin-Antitoxin System Regulation.
Front Microbiol: 2020, 11;113
[PubMed:32117138] [WorldCat.org] [DOI] (P e)

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757
JSNZ

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]