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⊟Summary[edit | edit source]
- pan ID?: SAUPAN002587000
- symbol?: mpfA
- synonym:
- description?: HlyC/CorC family transporter
- HlyC/CorC family transporter
- hemolysin
- hemolysin family protein
- magnesium and cobalt efflux protein, putative
- putative hemolysin
- CBS domain-containing protein
- CBS domain protein
- CorC
- Hemolysin-like protein containing CBS domains
- Hemolysin-related protein s containing CBS domains
- magnesium and cobalt efflux protein corC
- transporter associated domain protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3099491..3100840
- synteny block?: BlockID0018230
- occurrence?: in 100% of 34 strains
mpfA - primary magnesium export protein [1]
Under conditions of magnesium excess, staphylococci can export magnesium via MpfA or MpfB. MpfA is the dominant constitutive exporter and required for growth in high magnesium conditions. MpfB is an auxiliary magnesium exporter and, as part of the SigmaB stress regulon, can increase the basal flux of magnesium out of the cell.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0679
08BA02176:
C248_0786
11819-97:
MS7_0753
6850:
RSAU_000677
71193:
ST398NM01_0779
ECT-R 2:
ECTR2_653
ED133:
SAOV_0736
ED98:
SAAV_0664
HO 5096 0412:
SAEMRSA15_06280
JH1:
SaurJH1_0742
JH9:
SaurJH9_0726
JKD6008:
SAA6008_00718
JKD6159:
SAA6159_00657
JSNZ:
JSNZ_000670
LGA251:
SARLGA251_06350
M013:
M013TW_0688
MRSA252:
SAR0755
MSHR1132:
SAMSHR1132_06470
MSSA476:
SAS0667
Mu3:
SAHV_0699
Mu50:
SAV0702
MW2:
MW0664
RF122:
SAB0651
ST398:
SAPIG0779
T0131:
SAT0131_00772
TCH60:
HMPREF0772_12485
TW20:
SATW20_07770
USA300_TCH1516:
USA300HOU_0725
VC40:
SAVC_03145
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL METSTIISLIIFILLIALTTVFVGSEFALVKIRATRIEQLADEGNKPAKIVKKMIANLDY
N315 METSTIISLIIFILLIALTTVFVGSEFALVKIRATRIEQLADEGNKPAKIVKKMIANLDY
NCTC8325 METSTIISLIIFILLIALTTVFVGSEFALVKIRATRIEQLADEGNKPAKIVKKMIANLDY
Newman METSTIISLIIFILLIALTTVFVGSEFALVKIRATRIEQLADEGNKPAKIVKKMIANLDY
USA300_FPR3757 METSTIISLIIFILLIALTTVFVGSEFALVKIRATRIEQLADEGNKPAKIVKKMIANLDY
************************************************************
COL YLSACQLGITVTSLGLGWLGEPTFEKLLHPIFEAINLPTALTTTISFAVSFIIVTYLHVV
N315 YLSACQLGITVTSLGLGWLGEPTFEKLLHPIFEAINLPTALTTTISFAVSFIIVTYLHVV
NCTC8325 YLSACQLGITVTSLGLGWLGEPTFEKLLHPIFEAINLPTALTTTISFAVSFIIVTYLHVV
Newman YLSACQLGITVTSLGLGWLGEPTFEKLLHPIFEAINLPTALTTTISFAVSFIIVTYLHVV
USA300_FPR3757 YLSACQLGITVTSLGLGWLGEPTFEKLLHPIFEAINLPTALTTTISFAVSFIIVTYLHVV
************************************************************
COL LGELAPKSIAIQHTEKLALVYARPLFYFGNIMKPLIWLMNGSARVIIRMFGVNPDAQTDA
N315 LGELAPKSIAIQHTEKLALVYARPLFYFGNIMKPLIWLMNGSARVIIRMFGVNPDAQTDA
NCTC8325 LGELAPKSIAIQHTEKLALVYARPLFYFGNIMKPLIWLMNGSARVIIRMFGVNPDAQTDA
Newman LGELAPKSIAIQHTEKLALVYARPLFYFGNIMKPLIWLMNGSARVIIRMFGVNPDAQTDA
USA300_FPR3757 LGELAPKSIAIQHTEKLALVYARPLFYFGNIMKPLIWLMNGSARVIIRMFGVNPDAQTDA
************************************************************
COL MSEEEIKIIINNSYNGGEINQTELAYMQNIFSFDERHAKDIMVPRTQMITLNEPFNVDEL
N315 MSEEEIKIIINNSYNGGEINQTELAYMQNIFSFDERHAKDIMVPRTQMITLNEPFNVDEL
NCTC8325 MSEEEIKIIINNSYNGGEINQTELAYMQNIFSFDERHAKDIMVPRTQMITLNEPFNVDEL
Newman MSEEEIKIIINNSYNGGEINQTELAYMQNIFSFDERHAKDIMVPRTQMITLNEPFNVDEL
USA300_FPR3757 MSEEEIKIIINNSYNGGEINQTELAYMQNIFSFDERHAKDIMVPRTQMITLNEPFNVDEL
************************************************************
COL LETIKEHQFTRYPITDDGDKDHIKGFINVKEFLTEYASGKTIKIANYIHELPMISETTRI
N315 LETIKEHQFTRYPITDDGDKDHIKGFINVKEFLTEYASGKTIKIANYIHELPMISETTRI
NCTC8325 LETIKEHQFTRYPITDDGDKDHIKGFINVKEFLTEYASGKTIKIANYIHELPMISETTRI
Newman LETIKEHQFTRYPITDDGDKDHIKGFINVKEFLTEYASGKTIKIANYIHELPMISETTRI
USA300_FPR3757 LETIKEHQFTRYPITDDGDKDHIKGFINVKEFLTEYASGKTIKIANYIHELPMISETTRI
************************************************************
COL SDALIRMQREHVHMSLIIDEYGGTAGILTMEDILEEIVGEIRDEFDDDEVNDIVKIDNKT
N315 SDALIRMQREHVHMSLIIDEYGGTAGILTMEDILEEIVGEIRDEFDDDEVNDIVKIDNKT
NCTC8325 SDALIRMQREHVHMSLIIDEYGGTAGILTMEDILEEIVGEIRDEFDDDEVNDIVKIDNKT
Newman SDALIRMQREHVHMSLIIDEYGGTAGILTMEDILEEIVGEIRDEFDDDEVNDIVKIDNKT
USA300_FPR3757 SDALIRMQREHVHMSLIIDEYGGTAGILTMEDILEEIVGEIRDEFDDDEVNDIVKIDNKT
************************************************************
COL FQVNGRVLLDDLTEEFGIEFDDSEDIDTIGGWLQSRNTNLQKDDYVDTTYDRWVVSEIDN
N315 FQVNGRVLLDDLTEEFGIEFDDSEDIDTIGGWLQSRNTNLQKDDYVDTTYDRWVVSEIDN
NCTC8325 FQVNGRVLLDDLTEEFGIEFDDSEDIDTIGGWLQSRNTNLQKDDYVDTTYDRWVVSEIDN
Newman FQVNGRVLLDDLTEEFGIEFDDSEDIDTIGGWLQSRNTNLQKDDYVDTTYDRWVVSEIDN
USA300_FPR3757 FQVNGRVLLDDLTEEFGIEFDDSEDIDTIGGWLQSRNTNLQKDDYVDTTYDRWVVSEIDN
************************************************************
COL HQIIWVILNYEFNEARPTIGQSDEDEKSE
N315 HQIIWVILNYEFNEARPTIGQSDEDEKSE
NCTC8325 HQIIWVILNYEFNEARPTIGQSDEDEKSE
Newman HQIIWVILNYEFNEARPTIGQSDEDEKSE
USA300_FPR3757 HQIIWVILNYEFNEARPTIGQSDEDEKSE
*****************************
- ↑ Emilie Trachsel, Peter Redder, Patrick Linder, Joshua Armitano
Genetic screens reveal novel major and minor players in magnesium homeostasis of Staphylococcus aureus.
PLoS Genet: 2019, 15(8);e1008336
[PubMed:31415562] [WorldCat.org] [DOI] (I e)