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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003015000
- symbol?: mpfB
- synonym:
- description?: HlyC/CorC family transporter
- HlyC/CorC family transporter
- CNNM domain-containing protein
- DUF21 domain-containing protein
- ion transport modulator, putative
- CBS domain-containing protein
- CBS domain protein
- CorC
- Hemolysin-like protein containing CBS domains
- putative Mg2+ and Co2+ transporter, CorB
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3408857..3409897
- synteny block?: BlockID0021230
- occurrence?: in 97% of 34 strains
mpfB - auxiliary magnesium export protein [1]
Under conditions of magnesium excess, staphylococci can export magnesium via MpfA or MpfB. MpfA is the dominant constitutive exporter and required for growth in high magnesium conditions. MpfB is an auxiliary magnesium exporter and, as part of the SigmaB stress regulon, can increase the basal flux of magnesium out of the cell.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0874
08BA02176:
C248_0918
11819-97:
MS7_0875
6850:
RSAU_000798
71193:
ST398NM01_0903
ECT-R 2:
ECTR2_775
ED133:
SAOV_0866
ED98:
SAAV_0880
HO 5096 0412:
SAEMRSA15_07500
JH1:
SaurJH1_0936
JH9:
SaurJH9_0918
JKD6008:
SAA6008_00871
JKD6159:
SAA6159_00779
JSNZ:
JSNZ_000881
LGA251:
SARLGA251_08380
M013:
—
MRSA252:
SAR0882
MSHR1132:
SAMSHR1132_07720
MSSA476:
SAS0790
Mu3:
SAHV_0914
Mu50:
SAV0919
MW2:
MW0802
RF122:
SAB0786
ST398:
SAPIG0903
T0131:
SAT0131_00949
TCH60:
HMPREF0772_12327
TW20:
SATW20_09200
USA300_TCH1516:
USA300HOU_0878
VC40:
SAVC_03775
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MIIAIIILIFISFFFSGSETALTAANKAKFKTEADKGDKKAKGIVKLLEKPSEFITTILI
N315 MIIAIIILIFISFFFSGSETALTAANKTKFKTEADKGDKKAKGIVKLLEKPSEFITTILI
NCTC8325 MIIAIIILIFISFFFSGSETALTAANKTKFKTEADKGDKKAKGIVKLLEKPSEFITTILI
Newman MIIAIIILIFISFFFSGSETALTAANKTKFKTEADKGDKKAKGIVKLLEKPSEFITTILI
USA300_FPR3757 MIIAIIILIFISFFFSGSETALTAANKTKFKTEADKGDKKAKGIVKLLEKPSEFITTILI
***************************:********************************
COL GNNVANILLPTLVTIMALRWGISVGIASAVLTVVIILISEVIPKSVAATFPDKITRLVYP
N315 GNNVANILLPTLVTIMALRWGISVGIASAVLTVVIILISEVIPKSVAATFPDKITRLVYP
NCTC8325 GNNVANILLPTLVTIMALRWGISVGIASAVLTVVIILISEVIPKSVAATFPDKITRLVYP
Newman GNNVANILLPTLVTIMALRWGISVGIASAVLTVVIILISEVIPKSVAATFPDKITRLVYP
USA300_FPR3757 GNNVANILLPTLVTIMALRWGISVGIASAVLTVVIILISEVIPKSVAATFPDKITRLVYP
************************************************************
COL IINICVIVFRPITLLLNKLTDSINRSLSKGQPQEHQFSKEEFKTMLAIAGHEGALNEIET
N315 IINICVIVFRPITLLLNKLTDSINRSLSKGQPQEHQFSKEEFKTMLAIAGHEGALNEIET
NCTC8325 IINICVIVFRPITLLLNKLTDSINRSLSKGQPQEHQFSKEEFKTMLAIAGHEGALNEIET
Newman IINICVIVFRPITLLLNKLTDSINRSLSKGQPQEHQFSKEEFKTMLAIAGHEGALNEIET
USA300_FPR3757 IINICVIVFRPITLLLNKLTDSINRSLSKGQPQEHQFSKEEFKTMLAIAGHEGALNEIET
************************************************************
COL SRLEGVINFENLKVKDVDTTPRINVTAFASNATYEEVYETVMNKPYTRYPVYEGDIDNII
N315 SRLEGVINFENLKVKDVDTTPRINVTAFASNATYEEVYETVMNKPYTRYPVYEGDIDNII
NCTC8325 SRLEGVINFENLKVKDVDTTPRINVTAFASNATYEEVYETVMNKPYTRYPVYEGDIDNII
Newman SRLEGVINFENLKVKDVDTTPRINVTAFASNATYEEVYETVMNKPYTRYPVYEGDIDNII
USA300_FPR3757 SRLEGVINFENLKVKDVDTTPRINVTAFASNATYEEVYETVMNKPYTRYPVYEGDIDNII
************************************************************
COL GVFHSKYLLAWSNKKENQITNYSAKPLFVNEHNKAEWVLRKMTISRKHLAIVLDEFGGTE
N315 GVFHSKYLLAWSNKKEDQITNYSAKPLFVNEHNKAEWVLRKMTISRKHLAIVLDEFGGTE
NCTC8325 GVFHSKYLLAWSNKKENQITNYSAKPLFVNEHNKAEWVLRKMTISRKHLAIVLDEFGGTE
Newman GVFHSKYLLAWSNKKENQITNYSAKPLFVNEHNKAEWVLRKMTISRKHLAIVLDEFGGTE
USA300_FPR3757 GVFHSKYLLAWSNKKENQITNYSAKPLFVNEHNKAEWVLRKMTISRKHLAIVLDEFGGTE
****************:*******************************************
COL AIVSHEDLIEELLGMEIEDEMDKKEKEKLSQQQIQFQQRKNRNVSI
N315 AIVSHEDLIEELLGMEIEDEMDKKEKEKLSQQQIQFQQRKNRNVSI
NCTC8325 AIVSHEDLIEELLGMEIEDEMDKKEKEKLSQQQIQFQQRKNRNVSI
Newman AIVSHEDLIEELLGMEIEDEMDKKEKEKLSQQQIQFQQRKNRNVSI
USA300_FPR3757 AIVSHEDLIEELLGMEIEDEMDKKEKEKLSQQQIQFQQRKNRNVSI
**********************************************
- ↑ Emilie Trachsel, Peter Redder, Patrick Linder, Joshua Armitano
Genetic screens reveal novel major and minor players in magnesium homeostasis of Staphylococcus aureus.
PLoS Genet: 2019, 15(8);e1008336
[PubMed:31415562] [WorldCat.org] [DOI] (I e)