⊟Summary[edit | edit source]
- pan ID?: SAUPAN002543000
- symbol?: pitR
- synonym:
- description?: DUF47 domain-containing protein
- DUF47 domain-containing protein
- phosphate transport regulator, putative
- phosphate transport regulator
- pit accessory protein
- protein YkaA
- putative phosphate uptake regulator
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3056441..3057058
- synteny block?: BlockID0017790
- occurrence?: in 100% of 34 strains
pitR (phoU2) : persister formation, virulence factor and phosphate transport regulator PitR [1]
In Staphylococcus aureus, regulators of inorganic phosphate import systems have taken on additional roles as indirect regulators of persistence and virulence factor expression. PhoU and PitR, the regulators of PstSCAB and PitA, respectively, modulate expression of their respective inorganic phosphate transport systems. However, they moonlight to increase persister cell formation and intracellular bacterial survival (presumably through hyperactive carbon metabolism) and calibrate virulence factor production. Distinctions between the relative contributions of PhoU and PitR may be confounded by the different environmental conditions under which these regulators are activated. PhoU is induced by severe phosphate limitation whereas PitR is induced under modest phosphate limitation in acidic environments.
⊟Orthologs[edit | edit source]
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MFSKKKDKFMVQLEEMVFNLDRAAIEFGKMDFNTHLDLKAYSDNIKTYESHGDELVHQVI
N315 MFSKKKDKFMVQLEEMVFNLDRAAIEFGKMDFNTHLDLKAYSDNIKTYESHGDELVHQVI
NCTC8325 MFSKKKDKFMVQLEEMVFNLDRAAIEFGKMDFNTHLDLKAYSDNIKTYESHGDELVHQVI
Newman MFSKKKDKFMVQLEEMVFNLDRAAIEFGKMDFNTHLDLKAYSDNIKTYESHGDELVHQVI
USA300_FPR3757 MFSKKKDKFMVQLEEMVFNLDRAAIEFGKMDFNTHLDLKAYSDNIKTYESHGDELVHQVI
************************************************************
COL TDLNQTFITPIEREDILSLCDAIDDVLDAIEETAAMFEMYSIEYTDEYMAEFVDNIQKAV
N315 TDLNQTFITPIEREDILSLCDAIDDVLDAIEETAAMFEMYSIEYTDEYMAEFVDNIQKAV
NCTC8325 TDLNQTFITPIEREDILSLCDAIDDVLDAIEETAAMFEMYSIEYTDEYMAEFVDNIQKAV
Newman TDLNQTFITPIEREDILSLCDAIDDVLDAIEETAAMFEMYSIEYTDEYMAEFVDNIQKAV
USA300_FPR3757 TDLNQTFITPIEREDILSLCDAIDDVLDAIEETAAMFEMYSIEYTDEYMAEFVDNIQKAV
************************************************************
COL AEMKLAVGLLVDKKLSHMRIHSINIKEFETNCDGILRQSIKHIFNSETDPITLIKIKDIY
N315 AEMKLAVGLLVDKKLSHMRIHSINIKEFETNCDGILRQSIKHIFNSETDPITLIKIKDIY
NCTC8325 AEMKLAVGLLVDKKLSHMRIHSINIKEFETNCDGILRQSIKHIFNSETDPITLIKIKDIY
Newman AEMKLAVGLLVDKKLSHMRIHSINIKEFETNCDGILRQSIKHIFNSETDPITLIKIKDIY
USA300_FPR3757 AEMKLAVGLLVDKKLSHMRIHSINIKEFETNCDGILRQSIKHIFNSETDPITLIKIKDIY
************************************************************
COL ESMEEIADKCQIVANNFETIIMKNS
N315 ESMEEIADKCQIVANNFETIIMKNS
NCTC8325 ESMEEIADKCQIVANNFETIIMKNS
Newman ESMEEIADKCQIVANNFETIIMKNS
USA300_FPR3757 ESMEEIADKCQIVANNFETIIMKNS
*************************
- ↑ Lukas Mechler, Alexander Herbig, Kerstin Paprotka, Martin Fraunholz, Kay Nieselt, Ralph Bertram
A novel point mutation promotes growth phase-dependent daptomycin tolerance in Staphylococcus aureus.
Antimicrob Agents Chemother: 2015, 59(9);5366-76
[PubMed:26100694] [WorldCat.org] [DOI] (I p)Yongpeng Shang, Xiaofei Wang, Zhong Chen, Zhihui Lyu, Zhiwei Lin, Jinxin Zheng, Yang Wu, Qiwen Deng, Zhijian Yu, Ying Zhang, Di Qu
Staphylococcus aureus PhoU Homologs Regulate Persister Formation and Virulence.
Front Microbiol: 2020, 11;865
[PubMed:32670206] [WorldCat.org] [DOI] (P e)