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NCBI: 01-DEC-2025

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: EGJ38_000630 [new locus tag: EGJ38_RS03145 ]
  • pan locus tag?: SAUPAN002543000
  • symbol: pitR
  • pan gene symbol?: pitR
  • synonym:
  • alternate name: JSNZ_000630
  • product: DUF47 domain-containing protein

⊟Additional information (user-provided)[edit | edit source]

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EGJ38_000630 [new locus tag: EGJ38_RS03145 ]
  • symbol: pitR
  • product: DUF47 domain-containing protein
  • replicon: chromosome
  • strand: +
  • coordinates: 666066..666683
  • length: 618
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq: MGT2422608 NCBI
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

⊟Additional information (user-provided)[edit | edit source]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGTTTAGTAAGAAAAAAGATAAGTTTATGGTTCAATTAGAAGAGATGGTTTTCAATCTG
    GATCGTGCTGCTATTGAATTCGGTAAAATGGATTTCAATACACATTTAGATTTAAAAGCA
    TACTCAGACAACATTAAAACTTATGAGTCACATGGTGACGAATTAGTACATCAAGTAATT
    ACTGATTTAAATCAAACATTTATCACACCAATTGAACGTGAAGATATTTTATCATTATGT
    GATGCAATTGATGATGTTTTAGATGCAATTGAAGAAACGGCAGCTATGTTTGAAATGTAT
    TCAATCGAATACACAGATGAATATATGGCTGAGTTTGTTGATAACATTCAAAAAGCAGTT
    GCAGAAATGAAACTTGCTGTCGGCTTATTAGTCGATAAAAAATTATCACATATGCGTATT
    CATTCAATTAATATTAAAGAATTTGAAACAAACTGTGATGGTATTTTAAGACAGTCAATT
    AAACATATTTTCAATAGCGAAACAGATCCAATCACATTAATTAAAATAAAAGATATTTAT
    GAAAGCATGGAAGAAATTGCTGATAAATGTCAAATCGTAGCAAATAATTTTGAAACTATT
    ATTATGAAAAATAGCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    618


⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EGJ38_000630 [new locus tag: EGJ38_RS03145 ]
  • symbol: PitR
  • description: DUF47 domain-containing protein
  • length: 205
  • theoretical pI: 4.33227
  • theoretical MW: 23738
  • GRAVY: -0.207317

⊟Function[edit | edit source]

  • TIGRFAM:
    Hypothetical proteins Conserved TIGR00153 family protein (TIGR00153; HMM-score: 50.4)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    PhoU (CL0297) PhoU_div; Protein of unknown function DUF47 (PF01865; HMM-score: 72.4)
    and 3 more
    NTF2 (CL0051) NTF2_YvbJ; YvbJ NTF2-like domain (PF25155; HMM-score: 13)
    TPR (CL0020) V-ATPase_H_C; V-ATPase subunit H (PF11698; HMM-score: 12.7)
    no clan defined Ead_Ea22; Ead/Ea22-like protein (PF13935; HMM-score: 12.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.977
    • Cytoplasmic Membrane Score: 0.0021
    • Cell wall & surface Score: 0.0003
    • Extracellular Score: 0.0206
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.005397
    • TAT(Tat/SPI): 0.000239
    • LIPO(Sec/SPII): 0.000578
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: MGT2422608 NCBI
  • UniProt:

⊟Additional information (user-provided)[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MFSKKKDKFMVQLEEMVFNLDRAAIEFGKMDFNTHLDLKAYSDNIKTYESHGDELVHQVITDLNQTFITPIEREDILSLCDAIDDVLDAIEETAAMFEMYSIEYTDEYMAEFVDNIQKAVAEMKLAVGLLVDKKLSHMRIHSINIKEFETNCDGILRQSIKHIFNSETDPITLIKIKDIYESMEEIADKCQIVANNFETIIMKNS

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: GraR (repression) regulon
    GraR(response regulator)important in cationic antimicrobial peptide (CAMP) resistance;  [2]

⊟Additional information (user-provided)[edit | edit source]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Additional information (user-provided)[edit | edit source]

⊟Other information (user-provided)[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
    Operon-mapper: a web server for precise operon identification in bacterial and archaeal genomes.
    Bioinformatics: 2018, 34(23);4118-4120
    [PubMed:29931111] [WorldCat.org] [DOI] (I p)
  2. ↑ Mélanie Falord, Ulrike Mäder, Aurélia Hiron, Michel Débarbouillé, Tarek Msadek
    Investigation of the Staphylococcus aureus GraSR regulon reveals novel links to virulence, stress response and cell wall signal transduction pathways.
    PLoS One: 2011, 6(7);e21323
    [PubMed:21765893] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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