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Summary[edit | edit source]

  • pan ID?: SAUPAN003793000
  • symbol?: phoU
  • synonym:
  • description?: phosphate transport system regulatory protein PhoU

      descriptions from strain specific annotations:

    • phosphate transport system regulatory protein PhoU
    • phosphate signaling complex protein PhoU
    • phosphate transport system protein PhoU
    • phosphate transport system regulatory protein
    • PhoU family transcriptional regulator
    • negative regulator PhoU
    • phosphate transporter PhoU
    • phosphate transport system protein
    • phosphate transport system protein PhoU, putative
    • Phosphate uptake regulator, PhoU
    • phosphate uptake regulator PhoU
    • PhoU protein
    • PnaS family phosphate:sodium (Na+) symporter
    • putative phosphate transport system protein
  • strand?: -
  • coordinates?: 4087382..4088023
  • synteny block?: BlockID0028500
  • occurrence?: in 100% of 34 strains

phoU (phoU1) : persister formation, virulence factor and phosphate transport regulator PhoU [1]

In Staphylococcus aureus, regulators of inorganic phosphate import systems have taken on additional roles as indirect regulators of persistence and virulence factor expression. PhoU and PitR, the regulators of PstSCAB and PitA, respectively, modulate expression of their respective inorganic phosphate transport systems. However, they moonlight to increase persister cell formation and intracellular bacterial survival (presumably through hyperactive carbon metabolism) and calibrate virulence factor production. Distinctions between the relative contributions of PhoU and PitR may be confounded by the different environmental conditions under which these regulators are activated. PhoU is induced by severe phosphate limitation whereas PitR is induced under modest phosphate limitation in acidic environments.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    NWMN_1296 (phoU)
    USA300_FPR3757:
    04-02981:
    SA2981_1339 (phoU)
    08BA02176:
    C248_1424
    11819-97:
    MS7_1342 (phoU)
    6850:
    RSAU_001265 (phoU)
    71193:
    ST398NM01_1386
    ECT-R 2:
    ECTR2_1242 (phoU)
    ED133:
    SAOV_1394c
    ED98:
    SAAV_1367
    HO 5096 0412:
    SAEMRSA15_12490
    JH1:
    SaurJH1_1475
    JH9:
    SaurJH9_1446
    JKD6008:
    SAA6008_01349 (phoU)
    JKD6159:
    SAA6159_01252 (phoU)
    JSNZ:
    JSNZ_001369 (phoU)
    LGA251:
    SARLGA251_13020
    M013:
    M013TW_1330
    MRSA252:
    SAR1398
    MSHR1132:
    SAMSHR1132_12270
    MSSA476:
    SAS1326
    Mu3:
    SAHV_1373
    Mu50:
    SAV1385
    MW2:
    MW1273
    RF122:
    SAB1241c
    ST398:
    SAPIG1386 (phoU)
    T0131:
    SAT0131_01456
    TCH60:
    HMPREF0772_11823 (phoU)
    TW20:
    SATW20_13840
    USA300_TCH1516:
    USA300HOU_1319
    VC40:
    SAVC_06170

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MAIIRQRYQEQLDDLIKELRRLGANVYVSIENGIKSLSIDDRGFARQTVKNDKHINQLNY
    N315            MAIIRQRYQEQLDDLIKELRRLGANVYVSIENGIKSLSIDDRGFARQTVKNDKHINQLNY
    NCTC8325        MAIIRQRYQEQLDDLIKELRRLGANVYVSIENGIKSLSIDDRGFARQTVKNDKHINQLNY
    Newman          MAIIRQRYQEQLDDLIKELRRLGANVYVSIENGIKSLSIDDRGFARQTVKNDKHINQLNY
    USA300_FPR3757  MAIIRQRYQEQLDDLIKELRRLGANVYVSIENGIKSLSIDDRGFARQTVKNDKHINQLNY
                    ************************************************************

    COL             DINERVIMLITKQQPIASDLRMMISSLKIASDLERIGDNASSIANIRLRTKITDDYVLTR
    N315            DINERVIMLITKQQPIASDLRMMISSLKIASDLERIGDNASSIANIRLRTKITDDYVLTR
    NCTC8325        DINERVIMLITKQQPIASDLRMMISSLKIASDLERIGDNASSIANIRLRTKITDDYVLTR
    Newman          DINERVIMLITKQQPIASDLRMMISSLKIASDLERIGDNASSIANIRLRTKITDDYVLTR
    USA300_FPR3757  DINERVIMLITKQQPIASDLRMMISSLKIASDLERIGDNASSIANIRLRTKITDDYVLTR
                    ************************************************************

    COL             LKTMGKLAMLMLKDLDQAFKKKDTVLIREIIERDEDIDDLYSHIINATYLIDNDPFVAAQ
    N315            LKTMGKLAMLMLKDLDQAFKKKDTVLIREIIERDEDIDDLYSHIINATYLIDNDPFVAAQ
    NCTC8325        LKTMGKLAMLMLKDLDQAFKKKDTVLIREIIERDEDIDDLYSHIINATYLIDNDPFVAAQ
    Newman          LKTMGKLAMLMLKDLDQAFKKKDTVLIREIIERDEDIDDLYSHIINATYLIDNDPFVAAQ
    USA300_FPR3757  LKTMGKLAMLMLKDLDQAFKKKDTVLIREIIERDEDIDDLYSHIINATYLIDNDPFVAAQ
                    ************************************************************

    COL             AHLAARHLERIGDHIINIAESVYFYLTGTHYEQ
    N315            AHLAARHLERIGDHIINIAESVYFYLTGTHYEQ
    NCTC8325        AHLAARHLERIGDHIINIAESVYFYLTGTHYEQ
    Newman          AHLAARHLERIGDHIINIAESVYFYLTGTHYEQ
    USA300_FPR3757  AHLAARHLERIGDHIINIAESVYFYLTGTHYEQ
                    *********************************

  1. Yongpeng Shang, Xiaofei Wang, Zhong Chen, Zhihui Lyu, Zhiwei Lin, Jinxin Zheng, Yang Wu, Qiwen Deng, Zhijian Yu, Ying Zhang, Di Qu
    Staphylococcus aureus PhoU Homologs Regulate Persister Formation and Virulence.
    Front Microbiol: 2020, 11;865
    [PubMed:32670206] [WorldCat.org] [DOI] (P e)