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⊟Summary[edit | edit source]
- pan ID?: SAUPAN002289000
- symbol?: mcsB
- synonym:
- description?: protein arginine kinase
- protein arginine kinase
- ATP:guanido phosphotransferase
- ATP:guanido phosphotransferase, putative
- Arginine kinase
- ATP:guanido phosphotransferase, C-terminal catalytic domain protein
- ATP:guanido phosphotransferase family protein
- D-isomer specific 2-hydroxyacid dehydrogenase family protein
- putative ATP:guanido phosphotransferase
- putative ATP:guanido phosphotransferase YacI
- putative phosphotransferase
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 2809660..2810682
- synteny block?: BlockID0015880
- occurrence?: in 100% of 34 strains
mcsB : CtsR regulon protein-arginine kinase and ClpC chaperone McsB [1]
• A crystal structure is available: 8GQD
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0499
08BA02176:
C248_0596
11819-97:
MS7_0513
6850:
RSAU_000475
71193:
ST398NM01_0599
ECT-R 2:
ECTR2_477
ED133:
SAOV_0559
ED98:
SAAV_0485
HO 5096 0412:
SAEMRSA15_04500
JH1:
SaurJH1_0560
JH9:
SaurJH9_0546
JKD6008:
SAA6008_00530
JKD6159:
SAA6159_00477
JSNZ:
JSNZ_000481
LGA251:
SARLGA251_04590
M013:
M013TW_0508
MRSA252:
SAR0527
MSHR1132:
SAMSHR1132_04680
MSSA476:
SAS0481
Mu3:
SAHV_0521
Mu50:
SAV0524
MW2:
MW0479
RF122:
SAB0474
ST398:
SAPIG0599
T0131:
SAT0131_00574 (hsdS)
TCH60:
HMPREF0772_12667
TW20:
SATW20_05930
USA300_TCH1516:
USA300HOU_0517
VC40:
SAVC_02205
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL -MTHNIHDNISQWMKSNEETPIVMSSRIRLARNLENHVHPLMYATENDGFRVINEVQDAL
N315 -MTHNIHDNISQWMKSNEETPIVMSSRIRLARNLENHVHPLMYATENDGFRVINEVQDAL
NCTC8325 -MTHNIHDNISQWMKSNEETPIVMSSRIRLARNLENHVHPLMYATENDGFRVINEVQDAL
Newman MMTHNIHDNISQWMKSNEETPIVMSSRIRLARNLENHVHPLMYATENDGFRVINEVQDAL
USA300_FPR3757 -MTHNIHDNISQWMKSNEETPIVMSSRIRLARNLENHVHPLMYATENDGFRVINEVQDAL
***********************************************************
COL PNFELMRLDQMDQQSKMKMVAKHLISPELIKQPAAAVLVNDDESLSVMINEEDHIRIQAM
N315 PNFELMRLDQMDQQSKMKMVAKHLISPELIKQPAAAVLVNDDESLSVMINEEDHIRIQAM
NCTC8325 PNFELMRLDQMDQQSKMKMVAKHLISPELIKQPAAAVLVNDDESLSVMINEEDHIRIQAM
Newman PNFELMRLDQMDQQSKMKMVAKHLISPELIKQPAAAVLVNDDESLSVMINEEDHIRIQAM
USA300_FPR3757 PNFELMRLDQMDQQSKMKMVAKHLISPELIKQPAAAVLVNDDESLSVMINEEDHIRIQAM
************************************************************
COL GTDTTLQALYNQASSIDDELDRSLDISYDEQLGYLTTCPTNIGTGMRASVMLHLPGLSIM
N315 GTDTTLQALYNQASSIDDELDRSLDISYDEQLGYLTTCPTNIGTGMRASVMLHLPGLSIM
NCTC8325 GTDTTLQALYNQASSIDDELDRSLDISYDEQLGYLTTCPTNIGTGMRASVMLHLPGLSIM
Newman GTDTTLQALYNQASSIDDELDRSLDISYDEQLGYLTTCPTNIGTGMRASVMLHLPGLSIM
USA300_FPR3757 GTDTTLQALYNQASSIDDELDRSLDISYDEQLGYLTTCPTNIGTGMRASVMLHLPGLSIM
************************************************************
COL KRMTRIAQTINRFGYTIRGIYGEGSQVYGHTYQVSNQLTLGKSELEIIETLTEVVNQIIH
N315 KRMTRIAQTINRFGYTIRGIYGEGSQVYGHTYQVSNQLTLGKSELEIIETLTEVVNQIIH
NCTC8325 KRMTRIAQTINRFGYTIRGIYGEGSQVYGHTYQVSNQLTLGKSELEIIETLTEVVNQIIH
Newman KRMTRIAQTINRFGYTIRGIYGEGSQVYGHTYQVSNQLTLGKSELEIIETLTEVVNQIIH
USA300_FPR3757 KRMTRIAQTINRFGYTIRGIYGEGSQVYGHTYQVSNQLTLGKSELEIIETLTEVVNQIIH
************************************************************
COL EEKQIRQKLDTYNQLETQDRVFRSLGILQNCRMITMEEASYRLSEVKLGIDLNYIELQNF
N315 DEKQIRQKLDTYNQLETQDRVFRSLGILQNCRMITMEEASYRLSEVKLGIDLNYIELQNF
NCTC8325 EEKQIRQKLDTYNQLETQDRVFRSLGILQNCRMITMEEASYRLSEVKLGIDLNYIELQNF
Newman EEKQIRQKLDTYNQLETQDRVFRSLGILQNCRMITMEEASYRLSEVKLGIDLNYIELQNF
USA300_FPR3757 EEKQIRQKLDTYNQLETQDRVFRSLGILQNCRMITMEEASYRLSEVKLGIDLNYIELQNF
:***********************************************************
COL KFNELMVAIQSPFLLDEEDDKSVKEKRADILREHIK
N315 KFNELMVAIQSPFLLDEEDDKSVKEKRADILREHIK
NCTC8325 KFNELMVAIQSPFLLDEEDDKSVKEKRADILREHIK
Newman KFNELMVAIQSPFLLDEEDDKSVKEKRADILREHIK
USA300_FPR3757 KFNELMVAIQSPFLLDEEDDKSVKEKRADILREHIK
************************************
- ↑ Darren J Wozniak, Kiran B Tiwari, Rami Soufan, Radheshyam K Jayaswal
The mcsB gene of the clpC operon is required for stress tolerance and virulence in Staphylococcus aureus.
Microbiology (Reading): 2012, 158(Pt 10);2568-2576
[PubMed:22902728] [WorldCat.org] [DOI] (I p)Sabryna Junker, Sandra Maaβ, Andreas Otto, Stephan Michalik, Friedrich Morgenroth, Ulf Gerth, Michael Hecker, Dörte Becher
Spectral Library Based Analysis of Arginine Phosphorylations in Staphylococcus aureus.
Mol Cell Proteomics: 2018, 17(2);335-348
[PubMed:29183913] [WorldCat.org] [DOI] (I p)Nadine Prust, Pieter C van Breugel, Simone Lemeer
Widespread Arginine Phosphorylation in Staphylococcus aureus.
Mol Cell Proteomics: 2022, 21(5);100232
[PubMed:35421590] [WorldCat.org] [DOI] (I p)Kai Lu, Bingnan Luo, Xuan Tao, Yongbo Luo, Mingjun Ao, Bin Zheng, Xiang Xu, Xiaoyan Ma, Jingling Niu, Huinan Li, Yanxuan Xie, Zhennan Zhao, Peng Zheng, Guanbo Wang, Song Gao, Chao Wang, Wei Xia, Zhaoming Su, Zong-Wan Mao
Complex structure and activation mechanism of arginine kinase McsB by McsA.
Nat Chem Biol: 2024;
[PubMed:39232187] [WorldCat.org] [DOI] (I a)