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⊟Summary[edit | edit source]
- pan ID?: SAUPAN001868000
- symbol?: mepR
- synonym:
- description?: multidrug efflux MATE transporter transcriptional repressor MepR
- multidrug efflux MATE transporter transcriptional repressor MepR
- MarR family transcriptional regulator
- multidrug efflux transporter transcriptional repressor MepR
- MarR family regulatory protein
- transcriptional regulator, MarR family
- marR family protein
- mepA/mepB repressor and autoregulator
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 2363539..2363958
- synteny block?: BlockID0012420
- occurrence?: in 100% of 34 strains
mepR1: multidrug efflux pump 1 transcriptional repressor [1]
• A crystal structure is available: 3ECO
• MepR1 has a consensus DNA binding motif of: 5'-TnRTTAGAnnTCTAAYnA-3'
• The MepR1 Regulon consists of Two Genes
There is some confusion in the S. aureus literature regarding the MepRAB transporters. Multiple papers and two crystal structures are available referring to two separate operons as MepRAB. For clarity, we will annotate the operon between the ascorbate phosphotransferase operon and the glycerol-3-phosphate transporter (3ECO) as "Mep1" and the one between femX and sarV (4EM1) as Mep2.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0332
08BA02176:
C248_0388
11819-97:
MS7_0323
6850:
RSAU_000279
71193:
ST398NM01_0414
ECT-R 2:
ECTR2_293
ED133:
SAOV_0358
ED98:
SAAV_0301
HO 5096 0412:
SAEMRSA15_02890
JH1:
SaurJH1_0392
JH9:
SaurJH9_0382
JKD6008:
SAA6008_00310 (mepR)
JKD6159:
SAA6159_00308 (mepR)
JSNZ:
JSNZ_000288 (mepR)
LGA251:
SARLGA251_02940 (mepR)
M013:
M013TW_0313
MRSA252:
SAR0330
MSHR1132:
SAMSHR1132_03070
MSSA476:
SAS0310
Mu3:
SAHV_0330
Mu50:
SAV0333
MW2:
MW0310
RF122:
SAB0283
ST398:
SAPIG0414
T0131:
SAT0131_00338
TCH60:
HMPREF0772_10162
TW20:
SATW20_04010 (mepR)
USA300_TCH1516:
USA300HOU_0354
VC40:
SAVC_01415
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MEFTYSYLFRMISHEMKQKADQKLEQFDITNEQGHTLGYLYAHQQDGLTQNDIAKALQRT
N315 MEFTYSYLFRMISHEMKQKADQKLEQFDITNEQGHTLGYLYAHQQDGLTQNDIAKALQRT
NCTC8325 MEFTYSYLFRMISHEMKQKADQKLEQFDITNEQGHTLGYLYAHQQDGLTQNDIAKALQRT
Newman MEFTYSYLFRMISHEMKQKADQKLEQFDITNEQGHTLGYLYAHQQDGLTQNDIAKALQRT
USA300_FPR3757 MEFTYSYLFRMISHEMKQKADQKLEQFDITNEQGHTLGYLYAHQQDGLTQNDIAKALQRT
************************************************************
COL GPTVSNLLRNLERKKLIYRYVDAQDTRRKNIGLTTSGIKLVEAFTSIFDEMEQTLVSQLS
N315 GPTVSNLLRNLERKKLIYRYVDAQDTRRKNIGLTTSGIKLVEAFTSIFDEMEQTLVSQLS
NCTC8325 GPTVSNLLRNLERKKLIYRYVDAQDTRRKNIGLTTSGIKLVEAFTSIFDEMEQTLVSQLS
Newman GPTVSNLLRNLERKKLIYRYVDAQDTRRKNIGLTTSGIKLVEAFTSIFDEMEQTLVSQLS
USA300_FPR3757 GPTVSNLLRNLERKKLIYRYVDAQDTRRKNIGLTTSGIKLVEAFTSIFDEMEQTLVSQLS
************************************************************
COL EEENEQMKANLTKMLSSLQ
N315 EEENEQMKANLTKMLSSLQ
NCTC8325 EEENEQMKANLTKMLSSLQ
Newman EEENEQMKANLTKMLSSLQ
USA300_FPR3757 EEENEQMKANLTKMLSSLQ
*******************
- ↑ Muthiah Kumaraswami, Jason T Schuman, Susan M Seo, Glenn W Kaatz, Richard G Brennan
Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA.
Nucleic Acids Res: 2009, 37(4);1211-24
[PubMed:19129225] [WorldCat.org] [DOI] (I p)Ivan Birukou, Susan M Seo, Bryan D Schindler, Glenn W Kaatz, Richard G Brennan
Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR.
Nucleic Acids Res: 2014, 42(4);2774-88
[PubMed:24293644] [WorldCat.org] [DOI] (I p)