PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 02-MAR-2017

⊟Summary

• organism: Staphylococcus aureus COL
• locus tag: SACOL_RS06170 [old locus tag: SACOL1205 ]
• pan locus tag^?: SAUPAN003463000
• symbol: SACOL_RS06170
• pan gene symbol^?: divIVA
• synonym:
• product: cell division protein DivIVA

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SACOL_RS06170 [old locus tag: SACOL1205 ]
• symbol: SACOL_RS06170
• product: cell division protein DivIVA
• replicon: chromosome
• strand: +
• coordinates: 1210058..1210675
• length: 618
• essential: unknown other strains

⊟Accession numbers

• Location: NC_002951 (1210058..1210675) NCBI
• BioCyc: SACOL_RS06170 BioCyc
• MicrobesOnline: see SACOL1205

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  
  ATGCCTTTTACACCAAATGAAATTAAGAATAAAGAGTTTTCACGTGTAAAGAATGGTTTA
  GAACCTACTGAAGTTGCTAATTTTTTGGAGCAACTAAGCACTGAAATTGAACGTCTTAAA
  GAAGATAAAAAACAACTTGAAAAAGTAATCGAAGAGAGAGATACTAATATTAAGTCTTAT
  CAAGACGTGCATCAATCTGTAAGTGATGCTTTGATACAAGCTCAAAAAGCTGGTGAAGAA
  ACTAAGCAAGCTGCAGAGAAACAAGCTGAAGCGATTATAGCTAAGGCAGAAGCGCAAGCT
  AATCAAATGGTTGGTGACGCGGTAGAAAAAGCACGCCGTTTAGCATTCCAGACTGAAGAT
  ATGAAACGTCAATCAAAAGTATTTAGATCGCGTTTCCGTATGTTAGTTGAAGCGCAATTA
  GACTTATTAAAAAACGAAGATTGGGATTACTTGTTGAATTATGATTTAGACGCTGAACAA
  GTGACGCTTGAAAATATTCATCATTTGCATGAAAATGATTTAAAGCCAGATGAAGTTGCA
  GCAAATGCACAAAATAATGCATCAAATACACCAGACAATAATCAACAATCCAATGATTCA
  GAAACAACTAAGAAGTAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  618
  

⊟Protein

⊟General

• locus tag: SACOL_RS06170 [old locus tag: SACOL1205 ]
• symbol: SACOL_RS06170
• description: cell division protein DivIVA
• length: 205
• theoretical pI: 4.63557
• theoretical MW: 23513.8
• GRAVY: -1.00683

⊟Function

• TIGRFAM:
  DivIVA domain (TIGR03544; HMM-score: 29.9)
  and 5 more
  Genetic information processing DNA metabolism Other MutS2 family protein (TIGR01069; HMM-score: 12.7)
  Cellular processes Cellular processes Adaptations to atypical conditions phage shock protein B (TIGR02976; HMM-score: 10.8)
  Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase F0, B subunit (TIGR01144; EC 3.6.3.14; HMM-score: 5.6)
  ATP synthase archaeal, H subunit (TIGR02926; EC 3.6.3.14; HMM-score: 4.9)
  SH3 domain protein (TIGR04211; HMM-score: 4.8)
• TheSEED: see SACOL1205
• PFAM:
  no clan defined DivIVA; DivIVA protein (PF05103; HMM-score: 122.3)
  and 19 more
  ATP_synthase (CL0255) ATP-synt_B; ATP synthase B/B' CF(0) (PF00430; HMM-score: 19.7)
  no clan defined ISG65-75; Invariant surface glycoprotein (PF11727; HMM-score: 14.9)
  HTH (CL0123) ORC1_wHTH; Origin recognition complex subunit 1 C-terminal winged HTH domain (PF21312; HMM-score: 14.1)
  no clan defined FlaC_arch; Flagella accessory protein C (FlaC) (PF05377; HMM-score: 14)
  DUF6507; Family of unknown function (DUF6507) (PF20117; HMM-score: 13.1)
  Leu_zip; Leucine zipper (PF15294; HMM-score: 12.9)
  DUF3829_2nd; DUF3829-like, C-terminal domain (PF22219; HMM-score: 12.8)
  DUF1664; Protein of unknown function (DUF1664) (PF07889; HMM-score: 12.7)
  P-loop_NTPase (CL0023) UvrD_C; UvrD-like helicase C-terminal domain (PF13361; HMM-score: 12.6)
  NADP_Rossmann (CL0063) NAD_binding_5; Myo-inositol-1-phosphate synthase (PF07994; HMM-score: 12)
  ATP_synthase (CL0255) HrpE; HrpE/YscL/FliH and V-type ATPase subunit E (PF06188; HMM-score: 11.1)
  no clan defined YtxH; YtxH-like protein (PF12732; HMM-score: 10.8)
  ZYG-11_interact; Interactor of ZYG-11 (PF05884; HMM-score: 9.8)
  Dak2; DAK2 domain (PF02734; HMM-score: 9.2)
  CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 (PF10473; HMM-score: 9.2)
  GT-B (CL0113) FUT8_N_cat; Alpha-(1,6)-fucosyltransferase N- and catalytic domains (PF19745; HMM-score: 9.1)
  no clan defined SseC; Secretion system effector C (SseC) like family (PF04888; HMM-score: 8.7)
  LMBR1; LMBR1-like membrane protein (PF04791; HMM-score: 7.8)
  S5 (CL0329) EFL1; Elongation factor-like GTPase 1-like domain (PF25118; HMM-score: 7.6)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9864
  • Cytoplasmic Membrane Score: 0.0066
  • Cell wall & surface Score: 0.0009
  • Extracellular Score: 0.006
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.002206
  • TAT(Tat/SPI): 0.000287
  • LIPO(Sec/SPII): 0.000323
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 447039808 NCBI
• RefSeq: WP_001117064 NCBI
• UniProt: see SACOL1205

⊟Protein sequence

• MPFTPNEIKNKEFSRVKNGLEPTEVANFLEQLSTEIERLKEDKKQLEKVIEERDTNIKSYQDVHQSVSDALIQAQKAGEETKQAAEKQAEAIIAKAEAQANQMVGDAVEKARRLAFQTEDMKRQSKVFRSRFRMLVEAQLDLLKNEDWDYLLNYDLDAEQVTLENIHHLHENDLKPDEVAANAQNNASNTPDNNQQSNDSETTKK

⊟Experimental data

• experimentally validated: see SACOL1205
• protein localization: see SACOL1205
• quantitative data / protein copy number per cell: see SACOL1205
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: see SACOL1205

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications