From AureoWiki
Jump to navigation Jump to search

NCBI: 26-AUG-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus N315
  • locus tag: SA1170 [new locus tag: SA_RS06645 ]
  • pan locus tag?: SAUPAN003707000
  • symbol: katA
  • pan gene symbol?: katA
  • synonym:
  • product: catalase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SA1170 [new locus tag: SA_RS06645 ]
  • symbol: katA
  • product: catalase
  • replicon: chromosome
  • strand: +
  • coordinates: 1332093..1333616
  • length: 1524
  • essential: no DEG other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    ATGACTATGTCACAACAAGACAAAAAGTTAACTGGTGTTTTTGGGCATCCAGTATCAGAC
    CGAGAAAATAGTATGACAGCAGGGCCTAGGGGACCTCTTTTAATGCAAGATATTTACTTT
    TTAGAGCAAATGTCTCAATTTGATAGAGAAGTAATACCAGAACGTCGAATGCATGCCAAA
    GGTTCTGGTGCATTTGGGACATTTACTGTAACTAAAGATATAACAAAATATACGAATGCT
    AAAATATTCTCTGAAATAGGTAAGCAAACCGAAATGTTTGCCCGTTTCTCTACTGTAGCA
    GGAGAACGTGGTGCTGCTGATGCGGAGCGTGACATTCGAGGATTTGCGTTAAAGTTCTAC
    ACTGAAGAAGGGAACTGGGATTTAGTAGGGAATAACACACCAGTATTCTTCTTTAGAGAT
    CCAAAGTTATTTGTTAGTTTAAATCGTGCGGTGAAACGAGATCCTAGAACAAATATGAGA
    GATGCACAAAATAACTGGGATTTCTGGACGGGTCTTCCAGAAGCATTGCACCAAGTAACG
    ATCTTAATGTCAGATAGAGGGATTCCTAAAGATTTACGTCATATGCATGGGTTCGGTTCT
    CACACATACTCTATGTATAATGATTCTGGTGAACGTGTTTGGGTTAAATTCCATTTTAGA
    ACGCAACAAGGTATTGAAAACTTAACTGATGAAGAAGCTGCTGAAATTATAGCTACAGAT
    CGTGATTCATCTCAACGCGATTTATTCGAAGCCATTGAAAAAGGTGATTATCCAAAATGG
    ACAATGTATATTCAAGTAATGACTGAGGAACAAGCTAAAAACCATAAAGATAATCCATTT
    GATTTAACAAAAGTATGGTATCACGATGAGTATCCTCTAATTGAAGTTGGAGAGTTTGAA
    TTAAATAGAAATCCAGATAATTACTTTATGGATGTTGAACAAGCTGCGTTTGCACCAACT
    AATATTATTCCAGGATTAGATTTTTCTCCAGACAAAATGTTGCAAGGGCGTTTATTCTCA
    TATGGCGATGCGCAAAGATATCGATTAGGAGTTAATCATTGGCAGATTCCTGTAAACCAA
    CCTAAAGGTGTTGGTATTGAAAATATTTGTCCTTTTAGTAGAGATGGTCAAATGCGCGTA
    GTTGACAATAACCAAGGTGGAGGAACACATTATTATCCAAATAACCATGGTAAATTTGAT
    TCTCAACCTGAATATAAAAAGCCACCATTCCCAACTGATGGATACGGCTATGAATATAAT
    CAACGTCAAGATGATGATAATTATTTTGAACAACCAGGTAAATTGTTTAGATTACAATCA
    GAGGACGCTAAAGAAAGAATTTTTACAAATACAGCAAATGCAATGGAAGGCGTAACGGAT
    GATGTTAAACGACGTCATATTCGTCATTGTTACAAAGCTGACCCAGAATATGGTAAAGGT
    GTTGCAAAAGCATTAGGTATTGATATAAATTCTATTGATCTTGAAACTGAAAATGATGAA
    ACATACGAAAACTTTGAAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1524

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SA1170 [new locus tag: SA_RS06645 ]
  • symbol: KatA
  • description: catalase
  • length: 507
  • theoretical pI: 5.13252
  • theoretical MW: 58611.8
  • GRAVY: -0.840039

⊟Function[edit | edit source]

  • reaction:
    EC 1.11.1.6?  ExPASy
    Catalase 2 H2O2 = O2 + 2 H2O
  • TIGRFAM:
  • TheSEED  :
    • Catalase KatE (EC 1.11.1.6)
    Stress Response Oxidative stress Oxidative stress  Catalase (EC 1.11.1.6)
    and 1 more
    Stress Response Oxidative stress Protection from Reactive Oxygen Species  Catalase (EC 1.11.1.6)
  • PFAM:
    no clan defined Catalase; Catalase (PF00199; HMM-score: 606.9)
    and 1 more
    Catalase-rel; Catalase-related immune-responsive (PF06628; HMM-score: 80.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors: heme
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular possibility: 1
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: -1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.027357
    • TAT(Tat/SPI): 0.003516
    • LIPO(Sec/SPII): 0.001605
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTMSQQDKKLTGVFGHPVSDRENSMTAGPRGPLLMQDIYFLEQMSQFDREVIPERRMHAKGSGAFGTFTVTKDITKYTNAKIFSEIGKQTEMFARFSTVAGERGAADAERDIRGFALKFYTEEGNWDLVGNNTPVFFFRDPKLFVSLNRAVKRDPRTNMRDAQNNWDFWTGLPEALHQVTILMSDRGIPKDLRHMHGFGSHTYSMYNDSGERVWVKFHFRTQQGIENLTDEEAAEIIATDRDSSQRDLFEAIEKGDYPKWTMYIQVMTEEQAKNHKDNPFDLTKVWYHDEYPLIEVGEFELNRNPDNYFMDVEQAAFAPTNIIPGLDFSPDKMLQGRLFSYGDAQRYRLGVNHWQIPVNQPKGVGIENICPFSRDGQMRVVDNNQGGGTHYYPNNHGKFDSQPEYKKPPFPTDGYGYEYNQRQDDDNYFEQPGKLFRLQSEDAKERIFTNTANAMEGVTDDVKRRHIRHCYKADPEYGKGVAKALGIDINSIDLETENDETYENFEK

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: PerR* (repression) regulon, CodY (repression) regulon
    PerR*(TF)important in Oxidative stress response; RegPrecise 
    CodY(TF)important in Amino acid metabolism; RegPrecise 

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Alexander Scherl, Patrice François, Manuela Bento, Jacques M Deshusses, Yvan Charbonnier, Véronique Converset, Antoine Huyghe, Nadia Walter, Christine Hoogland, Ron D Appel, Jean-Charles Sanchez, Catherine G Zimmermann-Ivol, Garry L Corthals, Denis F Hochstrasser, Jacques Schrenzel
Correlation of proteomic and transcriptomic profiles of Staphylococcus aureus during the post-exponential phase of growth.
J Microbiol Methods: 2005, 60(2);247-57
[PubMed:15590099] [WorldCat.org] [DOI] (P p)Bonggoo Park, Victor Nizet, George Y Liu
Role of Staphylococcus aureus catalase in niche competition against Streptococcus pneumoniae.
J Bacteriol: 2008, 190(7);2275-8
[PubMed:18223076] [WorldCat.org] [DOI] (I p)

Retrieved from "http://fungenwikiserver.biologie.uni-greifswald.de/aureowiki/index.php?title=SA1170&oldid=96270"