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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_001991
  • pan locus tag?: SAUPAN005279000
  • symbol: agrC
  • pan gene symbol?: agrC
  • synonym:
  • product: quorum-sensing sensor histidine kinase AgrC

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_001991
  • symbol: agrC
  • product: quorum-sensing sensor histidine kinase AgrC
  • replicon: chromosome
  • strand: +
  • coordinates: 2004375..2005667
  • length: 1293
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    GTGGAAGCATTAAATGATTATAATTACGTTTTATTTGTAATTGTTCAAGTTTCATTAATG
    TTCTTTATATCTGCATTTATTAGTGGAATAAGATACAAAAAATCAGATTATATATACATT
    ATTGGAATAGTGTTATCTTCAGTATATTTCTTTGACAAAATCGGAAATATTTCACTAGTT
    GTTATAACAATTTTTATAATAATTTTTCTCTATTTTAAAATTAGACTATATTCTGTATTT
    TTAGTAATGGTTACTCAAATCATTTTATATTGTGCAAATTTCGTTTATATCATTATTTTT
    TCATACATTATAACAATTTCACACAGCGTGTTTATAGTTCTACCAATCTTTTTGGTAGTG
    TATGTATCAATTTCTTATGCACTTGCCTACATTTTAAATAGAATATTAAAAAGGATAAAT
    GGTACATACCTTTCTCTTAATAAAAAATTCCTTACTGTTATAACTATTGTTATAGTAATA
    ACATTCTCTTTGTTATTTGCATATTCGCAAATTGATGCGAGTGATGCATCAACAATCAAA
    CAGTATTCGCTTTTATTCTTGGGAATTATTATATTACTGAGTATCTTAATTTTTATTTAT
    TCTCAATTTACTCTTAAAGAAATGAAATATAAACGTAATCAAGAAGAAATTGAAACCTAT
    TATGAATACACATTAAAGATTGAAGCAATTAATAATGAAATGCGCAAGTTCCGTCATGAT
    TATGTCAATATCTTGACGACTCTTTCAGAATACATTCGTGAAGATGACATGACCGGTCTT
    CGAGACTATTTCAATAAAAATATTGTACCTATGAAAGATAATTTACAAATGAATGCTCTT
    AAGTTAAATGGTATTGAGAATCTTAAAGTACGTGAGATTAAAGGTCTTCTAACAGCTAAA
    ATTTTACGTGCACAAGAAATGAATATACCGATTAGTATAGAAATACCAGATGAAGTAACT
    CGCATTAATTTGAATATGATCGATTTAAGTCGCAGTATTGGTATTATTCTTGATAACGCA
    ATAGAGGCATCAAGTGAAATTGATGATCCTATCATTCGAGTTGCATTTATTGAAAGCGAA
    AATTCAGTAACGTTTATTGTTATGAATAAATGTGCAGATGATATACCACGTATTCATGAA
    TTGTTCCAAGAAAGTTTTTCTACTAAAGGTGAAGGTCGTGGTTTAGGTCTATCAACTTTA
    AAAGAAATTGCTGATAATGCAGACAATGTCTTATTAGATACAATTATCGAGAATGGTTTC
    TTTATTCAAAAGGTTGAAATTATTAACAACTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1293

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_001991
  • symbol: AgrC
  • description: quorum-sensing sensor histidine kinase AgrC
  • length: 430
  • theoretical pI: 5.15112
  • theoretical MW: 49655.1
  • GRAVY: 0.505116

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.13.3?  ExPASy
    Histidine kinase ATP + protein L-histidine = ADP + protein N-phospho-L-histidine
  • TIGRFAM:
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    His_Kinase_A (CL0025) HATPase_c_5; GHKL domain (PF14501; HMM-score: 88.6)
    and 4 more
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518; HMM-score: 27.1)
    GHD (CL0369) Glyco_hydro_30C; Glycosyl hydrolase family 30 beta sandwich domain (PF17189; HMM-score: 14.7)
    no clan defined SPOB_a; Sensor_kinase_SpoOB-type, alpha-helical domain (PF14689; HMM-score: 14.1)
    MTR4-like_stalk; Exosome RNA helicase MTR4-like, stalk (PF21408; HMM-score: 10.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 6
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0003
    • Cytoplasmic Membrane Score: 0.9884
    • Cell wall & surface Score: 0.0003
    • Extracellular Score: 0.011
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001991
    • TAT(Tat/SPI): 0.000139
    • LIPO(Sec/SPII): 0.02433
  • predicted transmembrane helices (TMHMM): 6

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MEALNDYNYVLFVIVQVSLMFFISAFISGIRYKKSDYIYIIGIVLSSVYFFDKIGNISLVVITIFIIIFLYFKIRLYSVFLVMVTQIILYCANFVYIIIFSYIITISHSVFIVLPIFLVVYVSISYALAYILNRILKRINGTYLSLNKKFLTVITIVIVITFSLLFAYSQIDASDASTIKQYSLLFLGIIILLSILIFIYSQFTLKEMKYKRNQEEIETYYEYTLKIEAINNEMRKFRHDYVNILTTLSEYIREDDMTGLRDYFNKNIVPMKDNLQMNALKLNGIENLKVREIKGLLTAKILRAQEMNIPISIEIPDEVTRINLNMIDLSRSIGIILDNAIEASSEIDDPIIRVAFIESENSVTFIVMNKCADDIPRIHELFQESFSTKGEGRGLGLSTLKEIADNADNVLLDTIIENGFFIQKVEIINN

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • data available for N315

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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