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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_000731
  • pan locus tag?: SAUPAN002672000
  • symbol: uvrB
  • pan gene symbol?: uvrB
  • synonym:
  • product: excinuclease ABC subunit UvrB

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_000731
  • symbol: uvrB
  • product: excinuclease ABC subunit UvrB
  • replicon: chromosome
  • strand: +
  • coordinates: 765234..767219
  • length: 1986
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    ATGGTTGAACATTATCCTTTTAAAATACATTCTGATTTTGAGCCTCAAGGTGACCAACCG
    CAAGCAATTAAGGAAATCGTGGAAGGTATTAAAGCGGGGAAAAGACATCAAACTTTATTA
    GGTGCAACTGGCACAGGGAAAACATTTACGATGAGTAATGTTATTAAAGAAGTTGGGAAA
    CCAACGTTAATTATCGCGCATAACAAAACATTAGCAGGACAATTATATAGTGAGTTTAAA
    GAATTTTTTCCTGAAAACAGGGTGGAATACTTTGTAAGTTACTATGATTATTATCAACCA
    GAGGCATACGTACCGTCTACTGACACTTTTATTGAAAAAGATGCCTCAATCAATGATGAA
    ATTGATCAACTACGACATTCTGCTACAAGTGCATTATTTGAACGCGATGATGTAATTATT
    ATTGCTAGTGTAAGTTGTATATATGGTTTAGGTAATCCTGAAGAATATAAAGATTTAGTA
    GTAAGTGTTCGAGTTGGTATGGAAATGGATAGAAGTGAATTACTTAGAAAACTTGTAGAT
    GTGCAATATACACGAAATGACATCGATTTCCAACGAGGAACGTTTCGAGTGCGTGGTGAT
    GTAGTTGAAATATTCCCAGCCTCTAAAGAAGAACTTTGTATAAGGGTTGAGTTTTTCGGC
    GATGAGATTGACCGTATCCGAGAAGTTAACTACCTAACAGGTGAAGTGTTGAAAGAAAGA
    GAACATTTTGCGATATTCCCAGCTTCTCACTTCGTAACACGTGAAGAAAAGTTGAAAGTT
    GCGATTGAACGTATTGAAAAAGAATTGGAAGAACGATTGAAAGAATTACGAGATGAGAAT
    AAATTACTAGAAGCGCAAAGGTTAGAACAGCGTACCAACTATGATTTAGAAATGATGCGA
    GAGATGGGATTCTGTTCAGGAATTGAAAACTATTCCGTACATTTAACTTTGCGGCCACTG
    GGTTCGACACCATATACTTTATTGGATTACTTTGGCGATGATTGGTTAGTAATGATTGAT
    GAATCACATGTGACATTACCGCAAGTTCGAGGCATGTATAACGGAGACAGAGCGCGTAAA
    CAAGTTTTGGTGGATCATGGATTTAGATTACCGAGTGCATTAGATAACCGTCCACTTAAA
    TTTGAAGAATTTGAAGAAAAGACAAAACAACTTGTGTATGTATCTGCAACGCCTGGACCA
    TACGAAATTGAACATACGGATAAGATGGTTGAACAAATTATTCGTCCTACTGGTTTACTG
    GATCCTAAGATTGAGGTTAGACCTACTGAAAATCAAATTGACGATTTATTAAGTGAAATT
    CAAACAAGGGTTGAGCGTAATGAACGCGTACTTGTTACAACGCTCACTAAAAAGATGAGT
    GAAGATTTAACCACATACATGAAAGAAACGGGTATTAAAGTTAATTATCTGCATTCAGAA
    ATCAAGACATTAGAACGAATCGAAATAATTAGAGACTTACGAATGGGTACATATGATGTT
    ATCGTAGGTATTAATTTATTAAGAGAGGGTATTGATATACCAGAAGTTTCTCTAGTTGTC
    ATATTAGATGCAGATAAAGAAGGGTTTTTACGTTCTAACCGCTCATTAATTCAAACAATA
    GGTAGAGCTGCGCGTAACGATAAAGGTGAAGTCATTATGTATGCCGATAAAATGACTGAT
    TCGATGAAGTATGCAATTGATGAGACACAACGTCGTCGAGAAATACAGATGAAACATAAT
    GAAAAACATGGTATTACTCCTAAAACAATTAATAAAAAAATACATGATTTAATTAGTGCT
    ACTGTTGAAAATGACGAAAATAATGACAAAGCACAAACTGTGATACCTAAGAAGATGACG
    AAAAAAGAACGTCAAAAGACAATCGACAATATAGAAAAAGAAATGAAACAAGCAGCGAAA
    GATTTAGATTTCGAGAAAGCTACAGAATTAAGAGATATGTTATTTGAATTAAAAGCAGAA
    GGGTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    1986

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_000731
  • symbol: UvrB
  • description: excinuclease ABC subunit UvrB
  • length: 661
  • theoretical pI: 5.05392
  • theoretical MW: 76677.8
  • GRAVY: -0.558396

⊟Function[edit | edit source]

  • reaction:
    EC 3.1.25.-?  ExPASy
  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit B (TIGR00631; EC 3.1.25.-; HMM-score: 1110)
    and 8 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair transcription-repair coupling factor (TIGR00580; EC 3.6.1.-; HMM-score: 64.7)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair ATP-dependent DNA helicase RecG (TIGR00643; EC 3.6.4.12; HMM-score: 47.1)
    DNA phosphorothioation system restriction enzyme (TIGR04095; HMM-score: 40.2)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair primosomal protein N' (TIGR00595; EC 3.6.1.-; HMM-score: 31.5)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair ATP-dependent DNA helicase, RecQ family (TIGR00614; EC 3.6.4.12; HMM-score: 28.1)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair ATP-dependent DNA helicase RecQ (TIGR01389; EC 3.6.4.12; HMM-score: 27.9)
    DEXH box helicase, DNA ligase-associated (TIGR04121; EC 3.6.4.-; HMM-score: 18.2)
    helicase/secretion neighborhood putative DEAH-box helicase (TIGR03817; HMM-score: 13.5)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    UB2H (CL0664) UvrB_inter; UvrB interaction domain (PF17757; HMM-score: 125.2)
    and 19 more
    P-loop_NTPase (CL0023) UvrB; Ultra-violet resistance protein B (PF12344; HMM-score: 83.9)
    Helicase_C; Helicase conserved C-terminal domain (PF00271; HMM-score: 77.8)
    ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 50.9)
    AAA_lid (CL0671) UVR; UvrB/uvrC motif (PF02151; HMM-score: 35.3)
    P-loop_NTPase (CL0023) DEAD; DEAD/DEAH box helicase (PF00270; HMM-score: 31.2)
    AAA_30; AAA domain (PF13604; HMM-score: 18.2)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 16.5)
    PDDEXK (CL0236) Sen15; Sen15 protein (PF09631; HMM-score: 16.2)
    P-loop_NTPase (CL0023) P-loop_SecA; SecA P-loop domain (PF21090; HMM-score: 15.8)
    AAA_19; AAA domain (PF13245; HMM-score: 14.7)
    AAA_22; AAA domain (PF13401; HMM-score: 14.2)
    Kinesin; Kinesin motor domain (PF00225; HMM-score: 13.2)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 12.9)
    HerA_C; Helicase HerA-like C-terminal (PF05872; HMM-score: 12.8)
    UB2H (CL0664) UB2H; Bifunctional transglycosylase second domain (PF14814; HMM-score: 12.7)
    P-loop_NTPase (CL0023) AAA_25; AAA domain (PF13481; HMM-score: 12.6)
    AAA_7; P-loop containing dynein motor region (PF12775; HMM-score: 11.8)
    no clan defined UFL1; E3 UFM1-protein ligase 1-like domain (PF23659; HMM-score: 11.7)
    P-loop_NTPase (CL0023) TrwB_AAD_bind; Type IV secretion-system coupling protein DNA-binding domain (PF10412; HMM-score: 11)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9704
    • Cytoplasmic Membrane Score: 0.0193
    • Cell wall & surface Score: 0.0003
    • Extracellular Score: 0.01
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.02003
    • TAT(Tat/SPI): 0.022381
    • LIPO(Sec/SPII): 0.000795
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MVEHYPFKIHSDFEPQGDQPQAIKEIVEGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLKEREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQTRVERNERVLVTTLTKKMSEDLTTYMKETGIKVNYLHSEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELKAEG

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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