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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_000480
  • pan locus tag?: SAUPAN002288000
  • symbol: JSNZ_000480
  • pan gene symbol?: mcsA
  • synonym:
  • product: UvrB/UvrC motif-containing protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_000480
  • symbol: JSNZ_000480
  • product: UvrB/UvrC motif-containing protein
  • replicon: chromosome
  • strand: +
  • coordinates: 509133..509699
  • length: 567
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    GTGCTTTGTGAAAATTGTCAACTTAATGAAGCGGAATTAAAAGTTAAAGTTACAAGTAAA
    AATAAAACAGAAGAAAAAATGGTGTGTCAAACTTGTGCTGAGGGGCACCATCCGTGGAAT
    CAAGCTAATGAACAACCTGAATATCAAGAACATCAAGATAATTTCGAAGAAGCATTTGTT
    GTTAAGCAAATTTTACAACATTTAGCTACGAAACATGGCATTAATTTTCAAGAAGTAGCG
    TTTAAAGAAGAAAAACGTTGCCCATCATGTCATATGACTTTGAAAGATATTGCACATGTT
    GGTAAATTTGGGTGTGCTAATTGTTATGCAACATTTAAAGATGACATCATTGATATCGTC
    CGCAGAGTTCAAGGTGGACAATTTGAGCACGTTGGAAAGACACCACATTCTTCACATAAA
    AAGATAGCTTTAAAGCGAAAAATCGAAGAAAAGAATGAATATTTGAAAAAACTTATTGAA
    ATCCAAGATTTTGAGGAAGCAGCCATTGTTAGAGATGAAATTAAAGCACTAAAAGCTGAG
    AGTGAGGTGCAACATGATGACGCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    567

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_000480
  • symbol: JSNZ_000480
  • description: UvrB/UvrC motif-containing protein
  • length: 188
  • theoretical pI: 6.43087
  • theoretical MW: 21702.5
  • GRAVY: -0.752128

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit B (TIGR00631; EC 3.1.25.-; HMM-score: 12.9)
    Metabolism Transport and binding proteins Cations and iron carrying compounds sodium/hydrogen antiporter (TIGR00844; HMM-score: 11.5)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    AAA_lid (CL0671) UVR; UvrB/uvrC motif (PF02151; HMM-score: 22.9)
    and 8 more
    Zn_Beta_Ribbon (CL0167) Cas12f1-like_TNB; Cas12f1-like, TNB domain (PF07282; HMM-score: 17.9)
    Zn_ribbon_IS1595; Transposase zinc-ribbon domain (PF12760; HMM-score: 17.5)
    no clan defined PHF5; PHF5-like protein (PF03660; HMM-score: 13.4)
    Zn_Beta_Ribbon (CL0167) Zn_ribbon_Elf1; Transcription elongation factor Elf1 like (PF05129; HMM-score: 10.6)
    DZR_2; Double zinc ribbon domain (PF18912; HMM-score: 8.6)
    RING (CL0229) zf-Vps39_C; Vacuolar sorting protein 39 C-terminal zinc finger domain (PF10367; HMM-score: 8.3)
    Zn_Beta_Ribbon (CL0167) Zn_ribbon_6; Double zinc ribbon (PF07191; HMM-score: 7.8)
    no clan defined DnaJ_CXXCXGXG; DnaJ central domain (PF00684; HMM-score: 7.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9879
    • Cytoplasmic Membrane Score: 0.0042
    • Cell wall & surface Score: 0.0004
    • Extracellular Score: 0.0076
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.020967
    • TAT(Tat/SPI): 0.000743
    • LIPO(Sec/SPII): 0.010674
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MLCENCQLNEAELKVKVTSKNKTEEKMVCQTCAEGHHPWNQANEQPEYQEHQDNFEEAFVVKQILQHLATKHGINFQEVAFKEEKRCPSCHMTLKDIAHVGKFGCANCYATFKDDIIDIVRRVQGGQFEHVGKTPHSSHKKIALKRKIEEKNEYLKKLIEIQDFEEAAIVRDEIKALKAESEVQHDDA

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CtsR* (repression) regulon
    CtsR*(TF)important in Heat shock response;  regulation predicted or transferred from N315 and NCTC 8325  [2]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
    Operon-mapper: a web server for precise operon identification in bacterial and archaeal genomes.
    Bioinformatics: 2018, 34(23);4118-4120
    [PubMed:29931111] [WorldCat.org] [DOI] (I p)
  2. ↑ Hannes Wolfgramm, Larissa Milena Busch, Jöran Tebben, Henry Mehlan, Lisa Hagenau, Thomas Sura, Tilly Hoffmüller, Elisa Bludau, Manuela Gesell Salazar, Alexander Reder, Stephan Michalik, Leif Steil, Kristin Surmann, Ulrike Mäder, Silva Holtfreter, Uwe Völker
    Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ.
    Curr Res Microb Sci: 2025, 9;100489
    [PubMed:41146725] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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