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⊟Summary[edit | edit source]
- pan ID?: SAUPAN002288000
- symbol?: mcsA
- synonym:
- description?: excinuclease ABC subunit B
- excinuclease ABC subunit B
- UvrB/UvrC motif-containing protein
- UvrB/UvrC domain protein
- Nucleotide excision repair protein, with UvrB/UvrC motif
- ClpC ATPase
- modulator of heat shock repressor CtsR
- UvrB/UvrC motif domain protein
- uvrB/uvrC motif family protein
- UvrB/UvrC protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 2809119..2809685
- synteny block?: BlockID0015870
- occurrence?: in 100% of 34 strains
mcsA : CtsR regulon protein-arginine kinase activator protein McsA [1]
• A crystal structure is available: 8GQD
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0498
08BA02176:
C248_0595
11819-97:
MS7_0512
6850:
RSAU_000474
71193:
ST398NM01_0598
ECT-R 2:
ECTR2_476
ED133:
SAOV_0558
ED98:
SAAV_0484
HO 5096 0412:
SAEMRSA15_04490
JH1:
SaurJH1_0559
JH9:
SaurJH9_0545
JKD6008:
SAA6008_00529
JKD6159:
SAA6159_00476 (cstR)
JSNZ:
JSNZ_000480
LGA251:
SARLGA251_04580
M013:
M013TW_0507
MRSA252:
SAR0526
MSHR1132:
SAMSHR1132_04670
MSSA476:
SAS0480
Mu3:
SAHV_0520
Mu50:
SAV0523
MW2:
MW0478
RF122:
SAB0473
ST398:
SAPIG0598
T0131:
SAT0131_00573
TCH60:
HMPREF0772_12668
TW20:
SATW20_05920
USA300_TCH1516:
USA300HOU_0516
VC40:
SAVC_02200
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MLCENCQLNEAELKVKVTSKNKTEEKMVCQTCAEGHHPWNQANEQPEYQEHQDNFEEAFV
N315 MLCENCQLNEAELKVKVTSKNKTEEKMVCQTCAEGHHPWNQANEQPEYQEHQDNFEEAFV
NCTC8325 --------------------------MVCQTCAEGHHPWNQANEQPEYQEHQDNFEEAFV
Newman --------------------------MVCQTCAEGHHPWNQANEQPEYQEHQDNFEEAFV
USA300_FPR3757 --------------------------MVCQTCAEGHHPWNQANEQPEYQEHQDNFEEAFV
**********************************
COL VKQILQHLATKHGINFQEVAFKEEKRCPSCHMTLKDIAHVGKFGCANCYATFKDDIIDIV
N315 VKQILQHLATKHGINFQEVAFKEEKRCPSCHMTLKDIAHVGKFGCANCYATFKDDIIDIV
NCTC8325 VKQILQHLATKHGINFQEVAFKEEKRCPSCHMTLKDIAHVGKFGCANCYATFKDDIIDIV
Newman VKQILQHLATKHGINFQEVAFKEEKRCPSCHMTLKDIAHVGKFGCANCYATFKDDIIDIV
USA300_FPR3757 VKQILQHLATKHGINFQEVAFKEEKRCPSCHMTLKDIAHVGKFGCANCYATFKDDIIDIV
************************************************************
COL RRVQGGQFEHVGKTPHSSHKKIALKRKIEEKNEYLKKLIEIQDFEEAAIVRDEIKALKAE
N315 RRVQGGQFEHVGKTPHSSHKKIALKRKIEEKNEYLKKLIEIQDFEEAAIVRDEIKALKAE
NCTC8325 RRVQGGQFEHVGKTPHSSHKKIALKRKIEEKNEYLKKLIEIQDFEEAAIVRDEIKALKAE
Newman RRVQGGQFEHVGKTPHSSHKKIALKRKIEEKNEYLKKLIEIQDFEEAAIVRDEIKALKAE
USA300_FPR3757 RRVQGGQFEHVGKTPHSSHKKIALKRKIEEKNEYLKKLIEIQDFEEAAIVRDEIKALKAE
************************************************************
COL SEVQHDDA
N315 SEVQHDDA
NCTC8325 SEVQHDDA
Newman SEVQHDDA
USA300_FPR3757 SEVQHDDA
********
- ↑ Kai Lu, Bingnan Luo, Xuan Tao, Yongbo Luo, Mingjun Ao, Bin Zheng, Xiang Xu, Xiaoyan Ma, Jingling Niu, Huinan Li, Yanxuan Xie, Zhennan Zhao, Peng Zheng, Guanbo Wang, Song Gao, Chao Wang, Wei Xia, Zhaoming Su, Zong-Wan Mao
Complex structure and activation mechanism of arginine kinase McsB by McsA.
Nat Chem Biol: 2024;
[PubMed:39232187] [WorldCat.org] [DOI] (I a)Sutthirat Sitthisak, Thawatchai Kitti, Kamala Boonyonying, Darren Wozniak, Skorn Mongkolsuk, Radheshyam K Jayaswal
McsA and the roles of metal-binding motif in Staphylococcus aureus.
FEMS Microbiol Lett: 2012, 327(2);126-33
[PubMed:22126623] [WorldCat.org] [DOI] (I p)