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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_000177
  • pan locus tag?: SAUPAN001105000
  • symbol: JSNZ_000177
  • pan gene symbol?: hmp
  • synonym:
  • product: globin domain-containing protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_000177
  • symbol: JSNZ_000177
  • product: globin domain-containing protein
  • replicon: chromosome
  • strand: -
  • coordinates: 216378..217523
  • length: 1146
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGCTTACAGAACAAGAGAAAGACATTATCAAACAAACAGTGCCTTTACTTAAAGAGAAA
    GGGACAGAAATTACGTCAATCTTTTATCCAAAAATGTTTAAAGCGCATCCTGAACTTTTA
    AACATGTTTAATCAAACGAACCAAAAACGAGGCATGCAATCTTCAGCATTAGCACAAGCT
    GTAATGGCCGCTGCGGTTAATATCGATAACTTAAGTGTTATTAAACCAGTCATTATGCCA
    GTCGCATATAAACACTGTGCATTACAAGTTTATGCTGAACATTATCCAATTGTGGGGGAA
    AATTTATTAAAAGCAATCCAAGACGTGACAGGTTTAGAAGAACATGACCCTGTGATTCAA
    GCTTGGGCAAAAGCATATGGTGTTATTGCGGATGTGTTCATCCAAATTGAAAAAGAAATT
    TATGATCAAATGATGTGGATTGGTTTTAAACCATTCAAAATTACCAATATTAAACAAGAA
    TCTGAAGACATTAAATCATTTACAGTTGAAACTGAAGAATATGACTTTAGTGAATTTACA
    CCAGGCCAATACATCACAGTTGATGTTTCTAGTGATAAACTTCCATATAGAGCTAAACGT
    CACTATTCTATCGTATCAGGTGAAAAAAACCATTTAACTTTTGGCGTTAAACGTGATGTC
    ACAACAGAACATGAAGGCGAAGTTTCAACAATTTTACACGATGAGATTAAAGAAGGCGAT
    ATGATTAATTTAGCTGCGCCTGTAGGTGGATTCGTATTAGAGAATACGACTGAACCACAA
    CTATTCTTAGGTTCAGGTATTGGCGTCACACCTTTAGTAGCAATGTATGAAGCTGCCTCT
    GCCAAAGGTTTAGATACACAGATGGTTCAAGTTGCTGAAAATGAACAACATTTACCTTTC
    AAAGACAACTTCAACAGTATCGCAAGCCATCATGACAACGCTAAATTATATACACACTTA
    AAAGATAAACAAGGCTATATTGGCGCTGAAGAATTACAAGTATTTTTAGCAAATAAACCT
    GAAATTTATATCTGTGGTGGTACAAAATTCTTACAATCTATGATCGAAGCACTTAAATCT
    TTAAATTACGATATGGATCGCGTACACTACGAAACATTTATTCCAAGACTAAGCGTTGCA
    GTATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1146

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_000177
  • symbol: JSNZ_000177
  • description: globin domain-containing protein
  • length: 381
  • theoretical pI: 5.06642
  • theoretical MW: 42930.8
  • GRAVY: -0.211024

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Energy metabolism Other phenylacetate-CoA oxygenase/reductase, PaaK subunit (TIGR02160; HMM-score: 56.5)
    and 1 more
    Metabolism Transport and binding proteins Cations and iron carrying compounds NADH:ubiquinone oxidoreductase, Na(+)-translocating, F subunit (TIGR01941; EC 1.6.5.-; HMM-score: 26.6)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    Globin (CL0090) Globin; Globin (PF00042; HMM-score: 48.3)
    and 4 more
    Hybrid (CL0105) FAD_binding_6; Oxidoreductase FAD-binding domain (PF00970; HMM-score: 34.7)
    NAD_Ferredoxin (CL0091) NAD_binding_1; Oxidoreductase NAD-binding domain (PF00175; HMM-score: 24.9)
    Hybrid (CL0105) AstE_AspA_hybrid; AstE/AspA barrel-sandwich hybrid domain (PF04952; HMM-score: 14.7)
    Globin (CL0090) Protoglobin; Protoglobin (PF11563; HMM-score: 13)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.97
    • Cytoplasmic Membrane Score: 0.0138
    • Cell wall & surface Score: 0.001
    • Extracellular Score: 0.0152
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.00738
    • TAT(Tat/SPI): 0.001641
    • LIPO(Sec/SPII): 0.000377
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MLTEQEKDIIKQTVPLLKEKGTEITSIFYPKMFKAHPELLNMFNQTNQKRGMQSSALAQAVMAAAVNIDNLSVIKPVIMPVAYKHCALQVYAEHYPIVGENLLKAIQDVTGLEEHDPVIQAWAKAYGVIADVFIQIEKEIYDQMMWIGFKPFKITNIKQESEDIKSFTVETEEYDFSEFTPGQYITVDVSSDKLPYRAKRHYSIVSGEKNHLTFGVKRDVTTEHEGEVSTILHDEIKEGDMINLAAPVGGFVLENTTEPQLFLGSGIGVTPLVAMYEAASAKGLDTQMVQVAENEQHLPFKDNFNSIASHHDNAKLYTHLKDKQGYIGAEELQVFLANKPEIYICGGTKFLQSMIEALKSLNYDMDRVHYETFIPRLSVAV

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: Rex* (repression) regulon
    Rex*(TF)important in Energy metabolism;  regulation predicted or transferred from N315 and NCTC 8325  [2]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
    Operon-mapper: a web server for precise operon identification in bacterial and archaeal genomes.
    Bioinformatics: 2018, 34(23);4118-4120
    [PubMed:29931111] [WorldCat.org] [DOI] (I p)
  2. ↑ Hannes Wolfgramm, Larissa Milena Busch, Jöran Tebben, Henry Mehlan, Lisa Hagenau, Thomas Sura, Tilly Hoffmüller, Elisa Bludau, Manuela Gesell Salazar, Alexander Reder, Stephan Michalik, Leif Steil, Kristin Surmann, Ulrike Mäder, Silva Holtfreter, Uwe Völker
    Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ.
    Curr Res Microb Sci: 2025, 9;100489
    [PubMed:41146725] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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