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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_000126
  • pan locus tag?: SAUPAN001024000
  • symbol: argC
  • pan gene symbol?: argC
  • synonym:
  • product: N-acetyl-gamma-glutamyl-phosphate reductase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_000126
  • symbol: argC
  • product: N-acetyl-gamma-glutamyl-phosphate reductase
  • replicon: chromosome
  • strand: -
  • coordinates: 149546..150577
  • length: 1032
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGATTAAAGTAGGTATCGTTGGCGGTAGCGGTTATGGCGCAATTGAATTAATTCGATTG
    TTACAAACACATCCTCATGTAACGATTGCACACATCTACTCACATTCAAAAGTAGATGAA
    CCGTTGAAATTAACATTTCCACATTTACAACATATTATGCAACATTTCGAAGCACTTACA
    GTGGACAATAATGACTGTGATGTAATTTTCTTTGCGACACCAGCACCCGTAAGTAAAACA
    TGTATCCCTCCCTTAGTAGAAAAAGGTATTCATGTTATCGATTTATCTGGCGCATTTAGA
    ATTAAGAATCGTGAAATATATGAAGCATATTACAAAGAAACTGCTGCAGCACAAGATGAT
    TTGAATCATGCTATTTACAGCATTTCAGAATGGCAATCGTTTGATAACAATGGAACGAAG
    CTCATTTCTAATCCTGGCTGTTTCCCTACAGCAACATTATTAGCATTACATCCACTTATT
    AGCGGAAAAATAGTAGATTTGTCATCTATTATTATTGATGCTAAGACCGGCGTGTCAGGT
    GCTGGTCGTTCATTATCACAACGTGTTCATTTTTCAGAAATGAATGAAAATCTAAGCGCT
    TATGCCATCGGAAACCATAAACACAAACCGGAAATCGAGCAATATTTATCTATCGTTGCG
    GGTCAAGATGTATCAGTCATATTTACACCACATCTCGTACCAATGACACGAGGTATTTTA
    TCAACAATTTATGTCAAATTATCATCTGAATATACGACTGAATCATTACATAAATTAATG
    ACCTCTTATTATGCTAATCAGCCATTTGTCAGAATTAGAGATATTGGGACTTTTCCAACC
    ACAAAAGAAGTACTCGGTAGTAACTACTGCGATATCGGTATCTATGTAGATGAAACAACG
    CAAACAGCAATTTTAGTATCAGTGATTGATAACCTTGTCAAAGGGGCAAGTGGTCAAGCC
    ATTCAAAATTTAAATATATTATATGATTTTGAAGTTACGACTGGCCTAAATCAATCACCA
    GTTTATCCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1032

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_000126
  • symbol: ArgC
  • description: N-acetyl-gamma-glutamyl-phosphate reductase
  • length: 343
  • theoretical pI: 6.33848
  • theoretical MW: 37803.9
  • GRAVY: 0.0239067

⊟Function[edit | edit source]

  • reaction:
    EC 1.2.1.38?  ExPASy
    N-acetyl-gamma-glutamyl-phosphate reductase N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Glutamate family N-acetyl-gamma-glutamyl-phosphate reductase (TIGR01850; EC 1.2.1.38; HMM-score: 438.3)
    and 4 more
    Metabolism Amino acid biosynthesis Glutamate family N-acetyl-gamma-glutamyl-phosphate reductase (TIGR01851; EC 1.2.1.38; HMM-score: 98.4)
    Metabolism Amino acid biosynthesis Aspartate family aspartate-semialdehyde dehydrogenase (TIGR00978; EC 1.2.1.11; HMM-score: 59.2)
    Metabolism Amino acid biosynthesis Aspartate family aspartate-semialdehyde dehydrogenase (TIGR01296; EC 1.2.1.11; HMM-score: 43.8)
    acetaldehyde dehydrogenase (acetylating) (TIGR03215; EC 1.2.1.10; HMM-score: 13)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    GADPH_aa-bio_dh (CL0139) Semialdhyde_dhC_1; Semialdehyde dehydrogenase, dimerisation domain (PF22698; HMM-score: 215.6)
    and 3 more
    Semialdhyde_dhC; Semialdehyde dehydrogenase, dimerisation domain (PF02774; HMM-score: 109)
    NADP_Rossmann (CL0063) Semialdhyde_dh; Semialdehyde dehydrogenase, NAD binding domain (PF01118; HMM-score: 92.2)
    GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold (PF01408; HMM-score: 17.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9885
    • Cytoplasmic Membrane Score: 0.0029
    • Cell wall & surface Score: 0.0005
    • Extracellular Score: 0.0081
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006392
    • TAT(Tat/SPI): 0.000302
    • LIPO(Sec/SPII): 0.0007
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MIKVGIVGGSGYGAIELIRLLQTHPHVTIAHIYSHSKVDEPLKLTFPHLQHIMQHFEALTVDNNDCDVIFFATPAPVSKTCIPPLVEKGIHVIDLSGAFRIKNREIYEAYYKETAAAQDDLNHAIYSISEWQSFDNNGTKLISNPGCFPTATLLALHPLISGKIVDLSSIIIDAKTGVSGAGRSLSQRVHFSEMNENLSAYAIGNHKHKPEIEQYLSIVAGQDVSVIFTPHLVPMTRGILSTIYVKLSSEYTTESLHKLMTSYYANQPFVRIRDIGTFPTTKEVLGSNYCDIGIYVDETTQTAILVSVIDNLVKGASGQAIQNLNILYDFEVTTGLNQSPVYP

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for NCTC8325
  • protein localization:
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: ArgR/AhrC (repression) regulon
    ArgR/AhrC(TF)important in Arginine biosynthesis, Arginine degradation;  regulation predicted or transferred from N315 and NCTC 8325  [2]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
    Operon-mapper: a web server for precise operon identification in bacterial and archaeal genomes.
    Bioinformatics: 2018, 34(23);4118-4120
    [PubMed:29931111] [WorldCat.org] [DOI] (I p)
  2. ↑ Hannes Wolfgramm, Larissa Milena Busch, Jöran Tebben, Henry Mehlan, Lisa Hagenau, Thomas Sura, Tilly Hoffmüller, Elisa Bludau, Manuela Gesell Salazar, Alexander Reder, Stephan Michalik, Leif Steil, Kristin Surmann, Ulrike Mäder, Silva Holtfreter, Uwe Völker
    Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ.
    Curr Res Microb Sci: 2025, 9;100489
    [PubMed:41146725] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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