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FunGene: 08-OCT-2024
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus JSNZ
- locus tag: JSNZ_000126
- pan locus tag?: SAUPAN001024000
- symbol: argC
- pan gene symbol?: argC
- synonym:
- product: N-acetyl-gamma-glutamyl-phosphate reductase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: JSNZ_000126
- symbol: argC
- product: N-acetyl-gamma-glutamyl-phosphate reductase
- replicon: chromosome
- strand: -
- coordinates: 149546..150577
- length: 1032
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Gene ID:
- RefSeq:
- BioCyc:
- MicrobesOnline:
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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1021ATGATTAAAGTAGGTATCGTTGGCGGTAGCGGTTATGGCGCAATTGAATTAATTCGATTG
TTACAAACACATCCTCATGTAACGATTGCACACATCTACTCACATTCAAAAGTAGATGAA
CCGTTGAAATTAACATTTCCACATTTACAACATATTATGCAACATTTCGAAGCACTTACA
GTGGACAATAATGACTGTGATGTAATTTTCTTTGCGACACCAGCACCCGTAAGTAAAACA
TGTATCCCTCCCTTAGTAGAAAAAGGTATTCATGTTATCGATTTATCTGGCGCATTTAGA
ATTAAGAATCGTGAAATATATGAAGCATATTACAAAGAAACTGCTGCAGCACAAGATGAT
TTGAATCATGCTATTTACAGCATTTCAGAATGGCAATCGTTTGATAACAATGGAACGAAG
CTCATTTCTAATCCTGGCTGTTTCCCTACAGCAACATTATTAGCATTACATCCACTTATT
AGCGGAAAAATAGTAGATTTGTCATCTATTATTATTGATGCTAAGACCGGCGTGTCAGGT
GCTGGTCGTTCATTATCACAACGTGTTCATTTTTCAGAAATGAATGAAAATCTAAGCGCT
TATGCCATCGGAAACCATAAACACAAACCGGAAATCGAGCAATATTTATCTATCGTTGCG
GGTCAAGATGTATCAGTCATATTTACACCACATCTCGTACCAATGACACGAGGTATTTTA
TCAACAATTTATGTCAAATTATCATCTGAATATACGACTGAATCATTACATAAATTAATG
ACCTCTTATTATGCTAATCAGCCATTTGTCAGAATTAGAGATATTGGGACTTTTCCAACC
ACAAAAGAAGTACTCGGTAGTAACTACTGCGATATCGGTATCTATGTAGATGAAACAACG
CAAACAGCAATTTTAGTATCAGTGATTGATAACCTTGTCAAAGGGGCAAGTGGTCAAGCC
ATTCAAAATTTAAATATATTATATGATTTTGAAGTTACGACTGGCCTAAATCAATCACCA
GTTTATCCATAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: JSNZ_000126
- symbol: ArgC
- description: N-acetyl-gamma-glutamyl-phosphate reductase
- length: 343
- theoretical pI: 6.33848
- theoretical MW: 37803.9
- GRAVY: 0.0239067
⊟Function[edit | edit source]
- reaction: EC 1.2.1.38? ExPASyN-acetyl-gamma-glutamyl-phosphate reductase N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH
- TIGRFAM: Amino acid biosynthesis Glutamate family N-acetyl-gamma-glutamyl-phosphate reductase (TIGR01850; EC 1.2.1.38; HMM-score: 438.3)and 4 moreAmino acid biosynthesis Glutamate family N-acetyl-gamma-glutamyl-phosphate reductase (TIGR01851; EC 1.2.1.38; HMM-score: 98.4)Amino acid biosynthesis Aspartate family aspartate-semialdehyde dehydrogenase (TIGR00978; EC 1.2.1.11; HMM-score: 59.2)Amino acid biosynthesis Aspartate family aspartate-semialdehyde dehydrogenase (TIGR01296; EC 1.2.1.11; HMM-score: 43.8)acetaldehyde dehydrogenase (acetylating) (TIGR03215; EC 1.2.1.10; HMM-score: 13)
- TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
- PFAM: GADPH_aa-bio_dh (CL0139) Semialdhyde_dhC_1; Semialdehyde dehydrogenase, dimerisation domain (PF22698; HMM-score: 215.6)and 3 moreSemialdhyde_dhC; Semialdehyde dehydrogenase, dimerisation domain (PF02774; HMM-score: 109)NADP_Rossmann (CL0063) Semialdhyde_dh; Semialdehyde dehydrogenase, NAD binding domain (PF01118; HMM-score: 92.2)GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold (PF01408; HMM-score: 17.8)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9885
- Cytoplasmic Membrane Score: 0.0029
- Cell wall & surface Score: 0.0005
- Extracellular Score: 0.0081
- LocateP:
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.006392
- TAT(Tat/SPI): 0.000302
- LIPO(Sec/SPII): 0.0007
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq:
- UniProt:
⊟Protein sequence[edit | edit source]
- MIKVGIVGGSGYGAIELIRLLQTHPHVTIAHIYSHSKVDEPLKLTFPHLQHIMQHFEALTVDNNDCDVIFFATPAPVSKTCIPPLVEKGIHVIDLSGAFRIKNREIYEAYYKETAAAQDDLNHAIYSISEWQSFDNNGTKLISNPGCFPTATLLALHPLISGKIVDLSSIIIDAKTGVSGAGRSLSQRVHFSEMNENLSAYAIGNHKHKPEIEQYLSIVAGQDVSVIFTPHLVPMTRGILSTIYVKLSSEYTTESLHKLMTSYYANQPFVRIRDIGTFPTTKEVLGSNYCDIGIYVDETTQTAILVSVIDNLVKGASGQAIQNLNILYDFEVTTGLNQSPVYP
⊟Experimental data[edit | edit source]
- experimentally validated: data available for NCTC8325
- protein localization:
- quantitative data / protein copy number per cell:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Regulation[edit | edit source]
- regulator: ArgR/AhrC (repression) regulon
ArgR/AhrC (TF) important in Arginine biosynthesis, Arginine degradation; regulation predicted or transferred from N315 and NCTC 8325 in Wolfgramm et al. (https://doi.org/10.1101/2025.09.03.674026)
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: data available for NCTC8325
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
- Aureolib: no data available
⊟Protein stability[edit | edit source]
- half-life: no data available
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
Operon-mapper: a web server for precise operon identification in bacterial and archaeal genomes.
Bioinformatics: 2018, 34(23);4118-4120
[PubMed:29931111] [WorldCat.org] [DOI] (I p)