PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 03-AUG-2016

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⊟Summary

• organism: Staphylococcus aureus NCTC8325
locus tag: SAOUHSC_02110
pan locus tag^?: SAUPAN004918000
symbol: SAOUHSC_02110
pan gene symbol^?: —
• synonym:
• product: hypothetical protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SAOUHSC_02110
• symbol: SAOUHSC_02110
• product: hypothetical protein
• replicon: chromosome
• strand: +
• coordinates: 1982508..1983062
• length: 555
• essential: no DEG other strains

⊟Accession numbers

• Gene ID: 3921182 NCBI
• RefSeq: YP_500602 NCBI
• BioCyc: G1I0R-1998 BioCyc
• MicrobesOnline: 1290558 MicrobesOnline

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  
  ATGATACAAGATGCGTTTGTTGCACTTGATTTTGAAACAGCAAATGGTAAACGTACAAGT
  ATTTGTTCTGTCGGAATGGTTAAAGTCATTGATAGTCAAATAACAGAAACATTTCATACT
  CTTGTGAATCCGCAAGACTATTTTTCACAACAAAATATTAAAATTCATGGCATACAACCA
  GAAGATGTTGAAAATGCACCTACGTTTGACTACGTATTTCCATATATGATGCAATTTATT
  GCAGATTTACCTGTTGTCGCACATAACGCGGCATTTGATATGAACGTCTTACATCAAAGC
  ATTCAAAATATTGGTTTACCAACTCCAAATTTAACTTACTTTTGTAGTTATCAACTTGCT
  AAAAGAACCGTTGATTCGTATCGATACGGTTTAAAACATATGATGGAGTTTTATCAATTA
  GATTTTCATGGTCATCATGATGCATTGAATGATGCCAAAGCATGCGCAATGATTACTTTT
  AGGCTACTGAAAAATTATGAAAATTTAACATATGTAACTAATATTTATGGTAAAAATCTA
  AAAGATAAAGGCTAG
  60
  120
  180
  240
  300
  360
  420
  480
  540
  555
  

⊟Protein

⊟General

• locus tag: SAOUHSC_02110
• symbol: SAOUHSC_02110
• description: hypothetical protein
• length: 184
• theoretical pI: 6.2936
• theoretical MW: 21120
• GRAVY: -0.209239

⊟Function

• ⊞TIGRFAM:
  Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, alpha subunit, Gram-positive type (TIGR01405; EC 2.7.7.7; HMM-score: 87.1)
  Genetic information processing DNA metabolism DNA replication, recombination, and repair putative DnaQ family exonuclease/DinG family helicase (TIGR01407; HMM-score: 81.4)
  Genetic information processing DNA metabolism Degradation of DNA exonuclease, DNA polymerase III, epsilon subunit family (TIGR00573; EC 2.7.7.7; HMM-score: 69.7)
  and 2 more
  Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, epsilon subunit (TIGR01406; EC 2.7.7.7; HMM-score: 67.5)
  Genetic information processing Transcription RNA processing ribonuclease T (TIGR01298; EC 3.1.13.-; HMM-score: 12.6)
• TheSEED  :
  • DNA polymerase III polC-type (EC 2.7.7.7)
• ⊞PFAM:
  RNase_H (CL0219) RNase_T; Exonuclease (PF00929; HMM-score: 91.2)
  and 3 more
  Rv2179c-like; 3'-5' exoribonuclease Rv2179c-like domain (PF16473; HMM-score: 44)
  DNA_pol_A_exo1; 3'-5' exonuclease (PF01612; HMM-score: 20.8)
  no clan defined DUF1265; Protein of unknown function (DUF1265) (PF06887; HMM-score: 13.2)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• ⊞DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9832
  • Cytoplasmic Membrane Score: 0.0049
  • Cell wall & surface Score: 0.0026
  • Extracellular Score: 0.0093
• ⊞LocateP: Intracellular
  • Prediction by SwissProt Classification: Cytoplasmic
  • Pathway Prediction: No pathway
  • Intracellular possibility: 1
  • Signal peptide possibility: -1
  • N-terminally Anchored Score: 1
  • Predicted Cleavage Site: No CleavageSite
• ⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.008011
  • TAT(Tat/SPI): 0.000547
  • LIPO(Sec/SPII): 0.0029
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 88195792 NCBI
• RefSeq: YP_500602 NCBI
• UniProt: Q2FWZ6 UniProt
• STRING: 93061.SAOUHSC_02110 STRING

⊟Protein sequence

• MIQDAFVALDFETANGKRTSICSVGMVKVIDSQITETFHTLVNPQDYFSQQNIKIHGIQPEDVENAPTFDYVFPYMMQFIADLPVVAHNAAFDMNVLHQSIQNIGLPTPNLTYFCSYQLAKRTVDSYRYGLKHMMEFYQLDFHGHHDALNDAKACAMITFRLLKNYENLTYVTNIYGKNLKDKG

⊟Experimental data

• experimentally validated: PeptideAtlas
• protein localization: data available for COL
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• predicted SigA promoter  : SAOUHSC_02108 > S828 > S829 > SAOUHSC_02110
  predicted SigA promoter  : S829 > SAOUHSC_02110

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser:   
  
  ⊟Multi-gene expression profiles

  Compare with:

  Conditions

  Select all flucRPMI-exp RPMI-exp-A2 vancRPMI-exp RPMI-exp-A1 TSB-exp-A TSB-exp-C ciproTSB-exp T/SmxTSB-exp clindTSB-exp lineTSB-exp eryTSB-exp TSB-exp-B3 flucTSB-exp TSB-exp-B2 vancTSB-exp TSB-exp-B1 RPMI/FCS-exp colist-exp intTHP1-2h intTHP1-6h intS9-6h intS9-2h TSB-t2-C TSB-t4-C flucTSB-t4 TSB-t2-B1 TSB-t4-B1 CDM-t2 CDM-t4 T/SmxTSB-t4 TSB-t4-B3 lineTSB-t4 TSB-t4-B2 vancTSB-t4 eryTSB-t4 clindTSB-t4 ciproTSB-t4 pMEM-t2-C1 pMEM-t4-C1 CO2-6h CO2-2h anaer-2h nonad50-1h CO2-1h nonad25-1h pMEM-exp-C2 pMEM-exp-C1 CDM-exp plasma-t4 vancRPMI-t4 flucRPMI-t4 RPMI-t4-A2 RPMI-t2-A1 plasma-exp

  
  
  Click on any data point to display a description of the corresponding condition!

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications