PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 03-AUG-2016

Views

More

• Read
• Edit
• History
• Edit source

⊟Summary

• organism: Staphylococcus aureus NCTC8325
locus tag: SAOUHSC_01951
pan locus tag^?: SAUPAN004577000
symbol: SAOUHSC_01951
pan gene symbol^?: epiC
• synonym:
• product: epidermin biosynthesis protein EpiC

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SAOUHSC_01951
• symbol: SAOUHSC_01951
• product: epidermin biosynthesis protein EpiC
• replicon: chromosome
• strand: -
• coordinates: 1853450..1854694
• length: 1245
• essential: no DEG

⊟Accession numbers

• Gene ID: 3920896 NCBI
• RefSeq: YP_500450 NCBI
• BioCyc: G1I0R-1812 BioCyc
• MicrobesOnline: 1290364 MicrobesOnline

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  1201
  
  ATGATTGATATGAATCTAATATTGAAGAAGAAGTTTCAAGAGATTTCAGAAGTAGATGAT
  TTCATTTCAAAAGCATCTACTGAAACCGATTATTTTGAACCTTCAACTTTATCACATGGT
  ATACCAGGTATCATTTTGTTTTTAGATGCTTATCAAAAAGTTTTCGATATTAATACTGAG
  CAAATTGTGCATAAGTACATCATGAAATTAGCACCATATTTACAGAGTGGTCAATATAAC
  AATTCTTTGTTTGGTGGACTTTCAGGTATTGCATTTTCAATGGATTTAGCATCGCAAAAT
  GGCAAAAATTATCAAAATATTTTAAATAATATTGATGGTCACATTGTAAATGAAATAGAA
  AATAAATTTGATCAAATATTACAAGAACCATTAAATCCATTAAATTATGATACTGTCAGT
  GGATTAGCTGGGATAGGGAGATATTTGCTAAATAGAGTAGATGAGAATGAATTTAATGTT
  AAAGCATTAAAAAGCATATTAGTATACTTTAAAGATATTCAATATTCTAAAAATAGCTGG
  GTAGTCCCACAAGAAAGTCAATTTTTAGAGTCTGATAAAAATTATTTTACTGAAGGTAAT
  ATCAATCTTGGCCTTGCACATGGAGTGCTAGGACCGATGTCTTTATTTGCATTATGCGTG
  ATTAAAGGAATTACGATTGAAAATCATCAGCACATATTAAAAGACATGTACAAATTTATC
  ATGGACGAAAAATTTTGTAACCACGAAAGATGGTTGCAGCGTTACGATTTAATTTCTGAA
  CGTAATCATTTCAATTTTATTCGGAATGGTTGGTGTTATGGCAATACGGGTGTAATGACG
  ACGTTGTTTTTAATCGGCCAAGCATTACAAGATGATGAAATAATTAAAATGTCTAAAAAA
  GTGATGCTACAAGTAGTAAATGATAAAGATGAAAATTTAATAAGTCCAACTATTTGTCAT
  GGATTGTCATCACAAATATTAATGTTAACAATTATGAATTTGAATTTTGAATTAAATGAA
  GTGTCTGATTATATCACTGTATTAATAAATAAACTGATTTCTCATTATAAGGAAGATTAT
  CTGGTGAATTTTATAGACATTAATGAAAATAAGCAAGATGTATTTAAAAGTAGGAAAGTT
  GGCCTTTTAGAAGGTGAATTAGGGGTCTATCTAACATTGATGACACTGAAAAATACAAAA
  ATTCTCAATGAAAAAAATTGGACCAATGCGTTTTTAATTAGCTGA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1140
  1200
  1245
  

⊟Protein

⊟General

• locus tag: SAOUHSC_01951
• symbol: SAOUHSC_01951
• description: epidermin biosynthesis protein EpiC
• length: 414
• theoretical pI: 5.15033
• theoretical MW: 47645.4
• GRAVY: -0.148309

⊟Function

• TIGRFAM:
  Cellular processes Cellular processes Toxin production and resistance type 2 lantibiotic biosynthesis protein LanM (TIGR03897; HMM-score: 60.8)
• TheSEED  :
  • Lanthionine biosynthesis cyclase LanC
• ⊞PFAM:
  6_Hairpin (CL0059) LANC_like; Lanthionine synthetase C-like protein (PF05147; HMM-score: 279.3)
  and 1 more
  no clan defined YppF; YppF-like protein (PF14178; HMM-score: 14.9)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• ⊞DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.4861
  • Cytoplasmic Membrane Score: 0.3403
  • Cell wall & surface Score: 0.0028
  • Extracellular Score: 0.1708
• ⊞LocateP: Intracellular
  • Prediction by SwissProt Classification: Cytoplasmic
  • Pathway Prediction: No pathway
  • Intracellular possibility: 1
  • Signal peptide possibility: -1
  • N-terminally Anchored Score: -1
  • Predicted Cleavage Site: No CleavageSite
• ⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.001413
  • TAT(Tat/SPI): 0.000105
  • LIPO(Sec/SPII): 0.000432
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 88195644 NCBI
• RefSeq: YP_500450 NCBI
• UniProt: Q2FXB4 UniProt
• STRING: 93061.SAOUHSC_01951 STRING

⊟Protein sequence

• MIDMNLILKKKFQEISEVDDFISKASTETDYFEPSTLSHGIPGIILFLDAYQKVFDINTEQIVHKYIMKLAPYLQSGQYNNSLFGGLSGIAFSMDLASQNGKNYQNILNNIDGHIVNEIENKFDQILQEPLNPLNYDTVSGLAGIGRYLLNRVDENEFNVKALKSILVYFKDIQYSKNSWVVPQESQFLESDKNYFTEGNINLGLAHGVLGPMSLFALCVIKGITIENHQHILKDMYKFIMDEKFCNHERWLQRYDLISERNHFNFIRNGWCYGNTGVMTTLFLIGQALQDDEIIKMSKKVMLQVVNDKDENLISPTICHGLSSQILMLTIMNLNFELNEVSDYITVLINKLISHYKEDYLVNFIDINENKQDVFKSRKVGLLEGELGVYLTLMTLKNTKILNEKNWTNAFLIS

⊟Experimental data

• experimentally validated:
• protein localization:
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: SAOUHSC_01945 < SAOUHSC_01947 < SAOUHSC_01948 < SAOUHSC_01949 < SAOUHSC_01950 < SAOUHSC_01951 < SAOUHSC_01952 < SAOUHSC_01953

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser:   
  
  ⊟Multi-gene expression profiles

  Compare with:

  Conditions

  Select all flucRPMI-exp RPMI-exp-A2 vancRPMI-exp RPMI-exp-A1 TSB-exp-A TSB-exp-C ciproTSB-exp T/SmxTSB-exp clindTSB-exp lineTSB-exp eryTSB-exp TSB-exp-B3 flucTSB-exp TSB-exp-B2 vancTSB-exp TSB-exp-B1 RPMI/FCS-exp colist-exp intTHP1-2h intTHP1-6h intS9-6h intS9-2h TSB-t2-C TSB-t4-C flucTSB-t4 TSB-t2-B1 TSB-t4-B1 CDM-t2 CDM-t4 T/SmxTSB-t4 TSB-t4-B3 lineTSB-t4 TSB-t4-B2 vancTSB-t4 eryTSB-t4 clindTSB-t4 ciproTSB-t4 pMEM-t2-C1 pMEM-t4-C1 CO2-6h CO2-2h anaer-2h nonad50-1h CO2-1h nonad25-1h pMEM-exp-C2 pMEM-exp-C1 CDM-exp plasma-t4 vancRPMI-t4 flucRPMI-t4 RPMI-t4-A2 RPMI-t2-A1 plasma-exp

  
  
  Click on any data point to display a description of the corresponding condition!

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications