PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 26-AUG-2013

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⊟Summary

• organism: Staphylococcus aureus N315
locus tag: SA1262 [new locus tag: SA_RS07155 ]
pan locus tag^?: SAUPAN003861000
symbol: SA1262
pan gene symbol^?: cvfC
• synonym:
• product: hypothetical protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SA1262 [new locus tag: SA_RS07155 ]
• symbol: SA1262
• product: hypothetical protein
• replicon: chromosome
• strand: -
• coordinates: 1434418..1435542
• length: 1125
• essential: no DEG other strains

⊟Accession numbers

• Gene ID: 1124100 NCBI
• RefSeq: NP_374543 NCBI
• BioCyc: see SA_RS07155
• MicrobesOnline: 103569 MicrobesOnline

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
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  1021
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  ATGGAAATTTTACGTATAGAGCCAACACCAAGTCCAAATACAATGAAAGTTGTTTTGTCA
  TATACAAGAGAAGACAAGTTATCTAATACTTATAAAAAAGTAGAAGAAACACAACCAAGA
  TTTATAAATCAGTTGTTATCTATAGATGGTATCACTTCCATTTTTCATGTCATGAACTTC
  TTAGCTGTTGATAAGGCACCAAAAGCTGATTGGGAAGTCATATTACCTGATATTAAAGCT
  GCTTTTTCTGATGCGAATAAGGTTTTAGAATCTGTAAATGAACCTCAAATTGACAATCAT
  TTTGGTGAAATTAAAGCTGAATTATTAACTTTTAAGGGTATACCGTATCAAATTAAGCTA
  ACTTCTGCTGACCAAGAATTAAGAGAACAATTACCACAAACATATGTTGATCATATGACT
  CAAGCGCAAACAGCACATGACAATATTGTTTTTATGCGTAAATGGCTAGATTTAGGAAAT
  CGCTATGGAAATATTGAAGAAGTAATGGATGGTGTCCTAGAAGAAGTGCTAGCTACCTAT
  CCAGAATCACAGTTACCCGTATTGGTAAAACATGCTTTAGAAGAAAATCACGCAACTAAT
  AATTATCATTTCTATCGACATGTCTCTTTGGATGAATATCATGCAACTGATAATTGGAAG
  ACTCGATTACGAATGTTAAACCATTTTCCAAAGCCGACTTTTGAAGATATACCGCTACTT
  GATTTAGCTTTATCTGATGAAAAAGTACCGGTTAGACGTCAAGCGATTGTATTATTAGGT
  ATGATTGAAAGTAAAGAAATTTTACCGTATTTATATAAGGGGCTTCGTGATAAAAGTCCT
  GCTGTAAGAAGAACAGCAGGGGATTGCATAAGCGATTTAGGGTATCCAGAGGCACTACCA
  GAAATGGTGCTACTATTAGATGATCCACAGAAAATCGTTAGGTGGCGTGCTGCTATGTTT
  ATCTTTGATGAAGGTAATGCAGAGCAGCTTCCCGCACTAAAAGCCCATATTAATGACAAT
  GCGTTTGAAGTTAAATTACAAATTGAAATGGCCATATCTCGTATTGAAAACGGAGATGAG
  GCACTTGGTTCAGTATGGAAACAAATGGCAAACAGAACAATTTAA
  60
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  1125
  

⊟Protein

⊟General

• locus tag: SA1262 [new locus tag: SA_RS07155 ]
• symbol: SA1262
• description: hypothetical protein
• length: 374
• theoretical pI: 5.00983
• theoretical MW: 42923.9
• GRAVY: -0.338235

⊟Function

• TIGRFAM:
• TheSEED  :
  • PBS lyase HEAT-like repeat domain protein
• ⊞PFAM:
  no clan defined Virulence_fact; Virulence factor (PF13769; HMM-score: 95.8)
  and 9 more
  TPR (CL0020) HEAT_2; HEAT repeats (PF13646; HMM-score: 69)
  Arg_repressor_C (CL0738) Nfu_N; Scaffold protein Nfu/NifU N terminal (PF08712; HMM-score: 64.1)
  TPR (CL0020) HEAT_EZ; HEAT-like repeat (PF13513; HMM-score: 40.1)
  HEAT; HEAT repeat (PF02985; HMM-score: 38.3)
  Cnd1; non-SMC mitotic condensation complex subunit 1 (PF12717; HMM-score: 28.5)
  HEAT_PBS; PBS lyase HEAT-like repeat (PF03130; HMM-score: 20.8)
  DUF5691; Family of unknown function (DUF5691) (PF18944; HMM-score: 16.5)
  no clan defined DUF5856; Family of unknown function (DUF5856) (PF19174; HMM-score: 12.9)
  TPR (CL0020) Adaptin_N; Adaptin N terminal region (PF01602; HMM-score: 10.7)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• ⊞DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9802
  • Cytoplasmic Membrane Score: 0.0173
  • Cell wall & surface Score: 0.0001
  • Extracellular Score: 0.0024
• ⊞LocateP: Intracellular
  • Prediction by SwissProt Classification: Cytoplasmic
  • Pathway Prediction: No pathway
  • Intracellular possibility: 1
  • Signal peptide possibility: -1
  • N-terminally Anchored Score: -1
  • Predicted Cleavage Site: No CleavageSite
• ⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.003062
  • TAT(Tat/SPI): 0.00031
  • LIPO(Sec/SPII): 0.000715
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 15927010 NCBI
• RefSeq: NP_374543 NCBI
• UniProt: Q99U59 UniProt

⊟Protein sequence

• MEILRIEPTPSPNTMKVVLSYTREDKLSNTYKKVEETQPRFINQLLSIDGITSIFHVMNFLAVDKAPKADWEVILPDIKAAFSDANKVLESVNEPQIDNHFGEIKAELLTFKGIPYQIKLTSADQELREQLPQTYVDHMTQAQTAHDNIVFMRKWLDLGNRYGNIEEVMDGVLEEVLATYPESQLPVLVKHALEENHATNNYHFYRHVSLDEYHATDNWKTRLRMLNHFPKPTFEDIPLLDLALSDEKVPVRRQAIVLLGMIESKEILPYLYKGLRDKSPAVRRTAGDCISDLGYPEALPEMVLLLDDPQKIVRWRAAMFIFDEGNAEQLPALKAHINDNAFEVKLQIEMAISRIENGDEALGSVWKQMANRTI

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: SA1261 < SA1262 < SA1263 < SA1264

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications