PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 06-JUL-2013

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⊟Summary

• organism: Staphylococcus aureus Newman
locus tag: NWMN_0469 [new locus tag: NWMN_RS02685 ]
pan locus tag^?: SAUPAN002248000
symbol: divIC
pan gene symbol^?: divIC
• synonym:
• product: cell-division initiation protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: NWMN_0469 [new locus tag: NWMN_RS02685 ]
• symbol: divIC
• product: cell-division initiation protein
• replicon: chromosome
• strand: +
• coordinates: 534163..534555
• length: 393
• essential: unknown other strains

⊟Accession numbers

• Gene ID: 5330251 NCBI
• RefSeq: YP_001331503 NCBI
• BioCyc:
• MicrobesOnline: 3706003 MicrobesOnline

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
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  ATGAAAAATAAAGTAGAACATATAGAAAATCAGTACACGTCGCAAGAGAACAAGAAAAAA
  CAACGTCAAAAAATGAAAATGCGTGTTGTTCGTAGGCGTATTACAGTATTTGCGGGCGTA
  TTACTTGCGATAATTGTTGTTTTATCAATCTTGCTTGTTGTCCAAAAACATCGCAATGAT
  ATTGATGCACAGGAGCGAAAAGCGAAAGAAGCACAGTTTCAAAAGCAACAAAATGAAGAA
  ATTGCGTTAAAAGAAAAGTTGAATAATCTGAATGACAAAGATTACATTGAAAAAATTGCG
  CGTGATGATTATTACTTAAGCAACAAAGGTGAAGTGATTTTTAGGTTGCCAGAAGACAAA
  GATTCGTCTAGCTCAAAATCTTCGAAAAAATAA
  60
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  393
  

⊟Protein

⊟General

• locus tag: NWMN_0469 [new locus tag: NWMN_RS02685 ]
• symbol: DivIC
• description: cell-division initiation protein
• length: 130
• theoretical pI: 10.4495
• theoretical MW: 15347.6
• GRAVY: -0.941538

⊟Function

• ⊞TIGRFAM:
  Cellular processes Cellular processes Cell division cell division protein FtsL (TIGR02209; HMM-score: 22)
  and 4 more
  cytochrome c oxidase accessory protein CcoG (TIGR02745; HMM-score: 16.6)
  TIGR03943 family protein (TIGR03943; HMM-score: 13.3)
  Genetic information processing Protein fate Protein folding and stabilization cytochrome c-type biogenesis protein CcmI (TIGR03142; HMM-score: 12.5)
  Metabolism Energy metabolism Electron transport cytochrome c-type biogenesis protein CcmI (TIGR03142; HMM-score: 12.5)
• ⊞TheSEED  :
  • Cell division protein DivIC (FtsB), stabilizes FtsL against RasP cleavage
  Bacterial Cell Division  Cell division protein DivIC (FtsB), stabilizes FtsL against RasP cleavage
  and 2 more
  Cell division-ribosomal stress proteins cluster  Cell division protein DivIC (FtsB), stabilizes FtsL against RasP cleavage
  RP Bacterial Cell Division  Cell division protein DivIC (FtsB), stabilizes FtsL against RasP cleavage
• ⊞PFAM:
  FtsL (CL0225) DivIC; Septum formation initiator (PF04977; HMM-score: 68.6)
  and 15 more
  TRAP (CL0757) SIT; SHP2-interacting transmembrane adaptor protein, SIT (PF15330; HMM-score: 16.3)
  TPR (CL0020) DUF6377; Domain of unknown function (DUF6377) (PF19904; HMM-score: 15.9)
  no clan defined Gemini_AL2; Geminivirus AL2 protein (PF01440; HMM-score: 15.5)
  DUF5305; Family of unknown function (DUF5305) (PF17231; HMM-score: 14.9)
  TRAP_alpha; Translocon-associated protein (TRAP), alpha subunit (PF03896; HMM-score: 13.9)
  EphA2_TM; Ephrin type-A receptor 2 transmembrane domain (PF14575; HMM-score: 13.5)
  INSIG-like (CL0798) INSIG; Insulin-induced protein (INSIG) (PF07281; HMM-score: 12.3)
  HTH (CL0123) WH_AprA; AprA winged helix domain (PF23589; HMM-score: 12.2)
  no clan defined LapA_dom; Lipopolysaccharide assembly protein A domain (PF06305; HMM-score: 12.1)
  MASE10; MASE10 (PF20970; HMM-score: 12.1)
  GPCR_A (CL0192) Frizzled; Frizzled/Smoothened family membrane region (PF01534; HMM-score: 10.5)
  Omega_toxin (CL0083) Conotoxin; Conotoxin (PF02950; HMM-score: 10.5)
  YhhM-like (CL0851) DUF2500; Protein of unknown function (DUF2500) (PF10694; HMM-score: 9.4)
  no clan defined Baculo_11_kDa; Baculovirus 11 kDa family (PF06143; HMM-score: 8.3)
  UPF0239; Uncharacterised protein family (UPF0239) (PF06783; HMM-score: 7.2)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞PSORTb: Cellwall
  • Cytoplasmic Score: 0.01
  • Cytoplasmic Membrane Score: 0.53
  • Cellwall Score: 8.75
  • Extracellular Score: 0.7
  • Internal Helix: 1
• ⊞DeepLocPro: Cytoplasmic Membrane
  • Cytoplasmic Score: 0
  • Cytoplasmic Membrane Score: 0.998
  • Cell wall & surface Score: 0
  • Extracellular Score: 0.002
• ⊞LocateP: N-terminally anchored (No CS)
  • Prediction by SwissProt Classification: Membrane
  • Pathway Prediction: Sec-(SPI)
  • Intracellular possibility: 0.17
  • Signal peptide possibility: -0.5
  • N-terminally Anchored Score: 4
  • Predicted Cleavage Site: No CleavageSite
• ⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.017308
  • TAT(Tat/SPI): 0.000593
  • LIPO(Sec/SPII): 0.005031
• predicted transmembrane helices (TMHMM): 1

⊟Accession numbers

• GI: 151220681 NCBI
• RefSeq: YP_001331503 NCBI
• UniProt: A0A0H3K6E6 UniProt

⊟Protein sequence

• MKNKVEHIENQYTSQENKKKQRQKMKMRVVRRRITVFAGVLLAIIVVLSILLVVQKHRNDIDAQERKAKEAQFQKQQNEEIALKEKLNNLNDKDYIEKIARDDYYLSNKGEVIFRLPEDKDSSSSKSSKK

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: divIC > NWMN_0470

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications