PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 06-JUL-2013

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⊟Summary

• organism: Staphylococcus aureus Newman
locus tag: NWMN_1094 [new locus tag: NWMN_RS06200 ]
pan locus tag^?: SAUPAN003454000
symbol: ftsQ
pan gene symbol^?: divIB
• synonym:
• product: cell division protein FtsQ

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: NWMN_1094 [new locus tag: NWMN_RS06200 ]
• symbol: ftsQ
• product: cell division protein FtsQ
• replicon: chromosome
• strand: +
• coordinates: 1198686..1200008
• length: 1323
• essential: unknown other strains

⊟Accession numbers

• Gene ID: 5332166 NCBI
• RefSeq: YP_001332128 NCBI
• BioCyc:
• MicrobesOnline: 3706646 MicrobesOnline

⊟Phenotype

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⊟DNA sequence

• 1
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  481
  541
  601
  661
  721
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  841
  901
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  1021
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  1141
  1201
  1261
  1321
  
  TTGATGGATGATAAAACGAAGAACGATCAACAAGAATCAAATGAAGATAAAGATGAATTA
  GAATTATTTACGAGGAATACATCTAAGAAAAGACGGCAAAGAAAAAGATCAAAGGCTACA
  CATTTTTCTAATCAAAATAAAGATGATACATCTCAACAAGCTGATTTTGATGAAGAAATT
  TACTTGATAAATAAAGACTTCAAAAAAGAAGAAAGCAATGATAAAAATAATGATTCTGCT
  TCTAGTCATGCGAATGATAATAATATCGATGATTCTACAGACTCTAATATTGAAAATGAG
  GATTATAGATATAATCAAGAAATTGACGACCAAAATGAATCGAATGTAATTTCAGTCGAC
  AACGAACAACCTCAATCAGCTCCTAAAGAACAAAATAGCGACTCGATTGATGAGGAAACA
  GTAACGAAAAAAGAACGAAAAAGTAAAGTAACACAATTAAAGCCATTAACACTTGAAGAA
  AAGCGGAAGTTAAGACGTAAGCGACAAAAGCGAATCCAATACAGTGTTATTACAATATTG
  GTATTGTTGATTGCTGTTATATTAATTTACATGTTTTCACCACTTAGTAAAATTGCGCAT
  GTAAATATAAATGGAAATAATCACGTTAGTACTTCAAAGATAAACAAAGTTTTAGGTGTT
  AAAAATGATTCAAGGATGTATACGTTTAGTAAAAAAAATGCTATTAATGATCTCGAAGAG
  AATCCATTAATCAAAAGTGTTGAGATACACAAGCAATTACCAAACACATTAAACGTAGAT
  ATCACAGAAAATGAAATTATTGCTTTAGTGAAATATAAAGGTAAATATTTACCTTTATTA
  GAAAATGGTAAATTGCTTAAAGGTTCAAATGATGTCAAAATTAATGATGCACCTGTCATG
  GATGGTTTCAAAGGTACAAAAGAAGATGATATGATTAAGGCGTTATCTGAAATGACACCT
  GAAGTTAGACGATATATTGCCGAAGTGACATACGCCCCAAGTAAAAACAAACAAAGCAGA
  ATTGAATTGTTTACGACAGATGGACTTCAAGTAATCGGTGATATTTCGACGATATCTAAG
  AAAATGAAATATTATCCGCAGATGTCACAATCATTATCAAGGGATAGTTCGGGTAAACTA
  AAAACACGAGGCTATATTGATTTATCAGTCGGTGCTTCATTTATCCCATACCGTGGAAAC
  ACGTCTAGTCAATCAGAAAGCGATAAAAATGTGACTAAATCATCTCAAGAGGAAAATCAA
  GCAAAAGAAGAATTACAAAGCGTTTTAAACAAAATTAACAAACAATCAAGTAAGAATAAT
  TAA
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⊟Protein

⊟General

• locus tag: NWMN_1094 [new locus tag: NWMN_RS06200 ]
• symbol: FtsQ
• description: cell division protein FtsQ
• length: 440
• theoretical pI: 8.50233
• theoretical MW: 50342.8
• GRAVY: -1.03136

⊟Function

• TIGRFAM:
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides LPS export ABC transporter permease LptF (TIGR04407; HMM-score: 12.9)
  Metabolism Transport and binding proteins Other LPS export ABC transporter permease LptF (TIGR04407; HMM-score: 12.9)
• TheSEED  :
  • Cell division protein FtsQ
  Cell Division and Cell Cycle Cell Division and Cell Cycle - no subcategory Bacterial Cytoskeleton  Cell division protein FtsQ
• ⊞PFAM:
  POTRA (CL0191) POTRA_1; POTRA domain, FtsQ-type (PF08478; HMM-score: 68.8)
  and 4 more
  no clan defined FtsQ_DivIB_C; Cell division protein FtsQ/DivIB, C-terminal (PF03799; HMM-score: 49.5)
  POTRA (CL0191) POTRA; Surface antigen variable number repeat (PF07244; HMM-score: 17.6)
  no clan defined T2SSF; Type II secretion system (T2SS), protein F (PF00482; HMM-score: 12.5)
  BPD_transp_1 (CL0404) LptF_LptG; Lipopolysaccharide export system permease LptF/LptG (PF03739; HMM-score: 11.7)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞PSORTb: Cellwall
  • Cytoplasmic Score: 0.01
  • Cytoplasmic Membrane Score: 0.53
  • Cellwall Score: 8.75
  • Extracellular Score: 0.7
  • Internal Helix: 1
• ⊞DeepLocPro: Cytoplasmic Membrane
  • Cytoplasmic Score: 0
  • Cytoplasmic Membrane Score: 0.992
  • Cell wall & surface Score: 0.0001
  • Extracellular Score: 0.0078
• ⊞LocateP: Intracellular /TMH start AFTER 60
  • Prediction by SwissProt Classification: Cytoplasmic
  • Pathway Prediction: Possibly Sec-
  • Intracellular possibility: 0.17
  • Signal peptide possibility: -1
  • N-terminally Anchored Score: 1
  • Predicted Cleavage Site: No CleavageSite
• ⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.012284
  • TAT(Tat/SPI): 0.005888
  • LIPO(Sec/SPII): 0.005543
• predicted transmembrane helices (TMHMM): 1

⊟Accession numbers

• GI: 151221306 NCBI
• RefSeq: YP_001332128 NCBI
• UniProt: A0A0H3KCB3 UniProt

⊟Protein sequence

• MMDDKTKNDQQESNEDKDELELFTRNTSKKRRQRKRSKATHFSNQNKDDTSQQADFDEEIYLINKDFKKEESNDKNNDSASSHANDNNIDDSTDSNIENEDYRYNQEIDDQNESNVISVDNEQPQSAPKEQNSDSIDEETVTKKERKSKVTQLKPLTLEEKRKLRRKRQKRIQYSVITILVLLIAVILIYMFSPLSKIAHVNINGNNHVSTSKINKVLGVKNDSRMYTFSKKNAINDLEENPLIKSVEIHKQLPNTLNVDITENEIIALVKYKGKYLPLLENGKLLKGSNDVKINDAPVMDGFKGTKEDDMIKALSEMTPEVRRYIAEVTYAPSKNKQSRIELFTTDGLQVIGDISTISKKMKYYPQMSQSLSRDSSGKLKTRGYIDLSVGASFIPYRGNTSSQSESDKNVTKSSQEENQAKEELQSVLNKINKQSSKNN

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: mraY > murD > ftsQ > ftsA > ftsZ

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications