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⊟Summary[edit | edit source]

  • pan ID?: SAUPAN004141000
  • symbol?: trmK
  • synonym:
  • ⊟description?: tRNA methyltransferase

      descriptions from strain specific annotations:

    • tRNA methyltransferase
    • methyltransferase, putative
    • tRNA (adenine(22)-N(1))-methyltransferase TrmK
    • tRNA (adenine-N(1))-methyltransferase
    • Putative tRNA-m1A22 methylase
    • Bcl-2 family protein
    • SAM-dependent methyltransferase
    • tRNA (adenine-N(1)-)-methyltransferase TrmK
  • strand?: -
  • coordinates?: 4409364..4410041
  • synteny block?: BlockID0031710
  • occurrence?: in 100% of 34 strains

trmK : tRNA adenosine(22) N(1)-methyltransferase [1]

• A crystal structure is available: 7O4M

Several transfer RNAs require modifications to provide maximal fidelity during protein synthesis. TrmK is a methyltransferase specific for adenosines at tRNA position 22 generating 1-methyladenosine ("m1A" or " " "). Staphylococcal tRNAs requiring this modification include: tRNAH1GUG, tRNAYGUA, tRNAEUUC, tRNASGCU, tRNASUGA.

⊟Orthologs[edit | edit source]

    COL:
    SACOL1617
    N315:
    SA1389
    NCTC8325:
    SAOUHSC_01661
    Newman:
    NWMN_1463
    USA300_FPR3757:
    SAUSA300_1520
    04-02981:
    SA2981_1518
    08BA02176:
    C248_1603
    11819-97:
    MS7_1577 (trmK)
    6850:
    RSAU_001425
    71193:
    ST398NM01_1625
    ECT-R 2:
    ECTR2_1410
    ED133:
    SAOV_1560
    ED98:
    SAAV_1552
    HO 5096 0412:
    SAEMRSA15_14800
    JH1:
    SaurJH1_1652
    JH9:
    SaurJH9_1618
    JKD6008:
    SAA6008_01529
    JKD6159:
    SAA6159_01495
    JSNZ:
    JSNZ_001551
    LGA251:
    SARLGA251_14660
    M013:
    M013TW_1575
    MRSA252:
    SAR1637
    MSHR1132:
    SAMSHR1132_14000
    MSSA476:
    SAS1498
    Mu3:
    SAHV_1547
    Mu50:
    SAV1560
    MW2:
    MW1512
    RF122:
    SAB1432c
    ST398:
    SAPIG1625
    T0131:
    SAT0131_01654
    TCH60:
    HMPREF0772_11580
    TW20:
    SATW20_15560
    USA300_TCH1516:
    USA300HOU_1562
    VC40:
    SAVC_07050

⊟Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

⊟Alignments[edit | edit source]

  • ⊞alignment of orthologues:

  1. ↑ Laura Antoine, Philippe Wolff, Eric Westhof, Pascale Romby, Stefano Marzi
    Mapping post-transcriptional modifications in Staphylococcus aureus tRNAs by nanoLC/MSMS.
    Biochimie: 2019, 164;60-69
    [PubMed:31295507] [WorldCat.org] [DOI] (I p)    Pamela Sweeney, Ashleigh Galliford, Abhishek Kumar, Dinesh Raju, Naveen B Krishna, Emmajay Sutherland, Caitlin J Leo, Gemma Fisher, Roopa Lalitha, Likith Muthuraj, Gladstone Sigamani, Verena Oehler, Silvia Synowsky, Sally L Shirran, Tracey M Gloster, Clarissa M Czekster, Pravin Kumar, Rafael G da Silva
    Structure, dynamics, and molecular inhibition of the Staphylococcus aureus m 1A22-tRNA methyltransferase TrmK.
    J Biol Chem: 2022, 298(6);102040
    [PubMed:35595101] [WorldCat.org] [DOI] (I p)
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