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NCBI: 02-MAR-2017
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus N315
- locus tag: SA_RS13955 [old locus tag: SA2434 ]
- pan locus tag?: SAUPAN006372000
- symbol: SA_RS13955
- pan gene symbol?: manP
- synonym:
- product: PTS mannose transporter subunit IIABC
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
⊟Accession numbers[edit | edit source]
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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1921ATGAAAATTGTAGCTATTACCTCATGCCCAAATGGCATTGCACATACATATATGGCTCAA
GAAAAGCTTGAGCAGGTAGCAAAAGAAATGGGTGTGGATATTAAAGTAGAGACACAGGGC
GGTGTTGGTGCTGAAAATGTTTTAACTACGCAAGACATCGAAGAAGCTGACGGTGTCATA
ATTGCAGCTGATAAACAAGTTGATCTATCCCGATTTGTTGGTAAACGGTTGATTAATGAA
AATGTTCGCGAAGGGATTCATAATCCGAGAGGTCTAATTCAACGTATCATTAATCAAGAT
GCGCCTATTTATCAATCTGAAACAAATTATCATTCGAAAGATCGCGGTAAGTCTAAAAGT
GGTATTCAAATGGTGTATCAACATTTAATGAACGGTGTATCGTTTATGGTTCCTTTTATC
GTAGTTGGTGGACTCCTTATCGCCATCGCGCTGACTCTAGGCGGTGAAACGACATCAAAA
GGATTAGTCATCCCAGATGATTCATTTTGGAAATCCATTGAAAACATTGGTAGTTTAGCC
TTTAAATTTATGGTTCCAATACTAGCTGGATATATCGCTGTTAGTATCGCTGACAAGCCC
GGTCTTGTTCCTGGTATGATTGGCGGCGCTATCGCTGCTGACGGTAGTTTTTATGGCAGT
GATGCAGGCGCAGGATTTTTAGGTGGTATTGTTGCTGGTTTCTTAGCAGGTTATATCGCA
AAGTGGATTAAAGATATTAAAGTTCCAAAAGCAATGGCACCAATTATGCCTATCATTATT
ATTCCCATTATTTCATCGGTCGTTGTAGGATTGATATTTATATTTTTAATCGGTGCACCA
ATTTCTAATATTTTTGAGGCATTAACAACCTGGTTAAAAAGTATGCAAGGTGCTAATATT
ATTATACTTGCGATGATTATAGGTGCGATGATCGCCTTCGATATGGGCGGTCCAGTAAAC
AAGGTAGCATTTTTATTTGGCTCAGCACTTATTGCTGAAGGTAATTACGCCGTTATGGGT
ATGGTCGCAGTTGCTGTATGTACACCACCAATCGGTTTAGGTTTAGCAACGTTTGTTCAA
AAGTATAAATTCAATCATTCCGAAAGAGAAATGGGTAAGGCTTCCTTCACTATGGGACTA
TTTGGTATTACTGAAGGTGCTATTCCTTTCGCAGCCCAAGATCCATTGCGCATTATACCT
GCAAACATCATTGGTGCAATGATTGCATCAGTCATTGCAGCCATTGGTGGTGTCGGCGAT
AGAGTCGCACATGGAGGTCCAATCGTGGCTGTATTAGGTGGTATTGATCATGTATTATGG
TTTATCTTTGCAGTGATAGTAGGTAGTCTTGTCACAATGACTACTGTACTATTATTAAAA
CGCAATACACCAGTTATAGCAGTAGATGCACCAGCGCAACACACGCAACTTCATGATACA
GATATTACACAACATGATACAGAGGTTGACAATGTAGATAAAACCGCGAAACATTCACAT
CTCAATAAACCTTCTCATGTTTTTGATCAACAAACTATGATAATTACTGATCACGACATG
TCTCGAAACGAAGCAATTGATATGTTGATTCATAAACTTAAAATTTGCCGTTATGTAGAG
CACACATCGCATTTAAAAAATGCAATACTAGAACGTGAAATGGAGTCTACGACAGCTATT
GGCATGAACGTGGCCATTCCACATGCAAAGTCTGATGTTGTAAAACAACCGATTGTAGCT
GTTATGAAAAATAATCATGGTGTTAAATGGGACAGTCTAGATGGTAGTCTACCTCAATTG
ATATTCTTAATTGCCGTACCAAACAACAGTCAGGATACACATTTAAAAATACTTCAGCGC
TTATCTAAAGCGTTAATGAATGATGAGACACGCCAATCACTAATTAATGCAAACAGTACT
ACAGAAATTTATAACTTATTAATGAAAATATAG60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SA_RS13955 [old locus tag: SA2434 ]
- symbol: SA_RS13955
- description: PTS mannose transporter subunit IIABC
- length: 650
- theoretical pI: 6.86598
- theoretical MW: 69869.3
- GRAVY: 0.344462
⊟Function[edit | edit source]
- TIGRFAM: PTS system, Fru family, IIC component (TIGR01427; HMM-score: 310.9)and 6 moreTransport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, fructose subfamily, IIA component (TIGR00848; EC 2.7.1.69; HMM-score: 150.3)Signal transduction PTS PTS system, fructose subfamily, IIA component (TIGR00848; EC 2.7.1.69; HMM-score: 150.3)Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, Fru family, IIB component (TIGR00829; EC 2.7.1.69; HMM-score: 112.2)Signal transduction PTS PTS system, Fru family, IIB component (TIGR00829; EC 2.7.1.69; HMM-score: 112.2)Signal transduction PTS PTS IIA-like nitrogen-regulatory protein PtsN (TIGR01419; HMM-score: 59.2)PTS system, sucrose-specific IIBC component (TIGR01996; EC 2.7.1.69; HMM-score: 19.2)
- TheSEED: see SA2434
- PFAM: PTase-anion_tr (CL0340) PTS_EIIA_2; Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 (PF00359; HMM-score: 115.3)and 2 morePTS_EIIC (CL0493) PTS_EIIC; Phosphotransferase system, EIIC (PF02378; HMM-score: 84.8)Phosphatase (CL0031) PTS_IIB; PTS system, Lactose/Cellobiose specific IIB subunit (PF02302; HMM-score: 60.5)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic Membrane
- Cytoplasmic Score: 0
- Cytoplasmic Membrane Score: 10
- Cellwall Score: 0
- Extracellular Score: 0
- Internal Helices: 8
- LocateP:
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.015421
- TAT(Tat/SPI): 0.000298
- LIPO(Sec/SPII): 0.002353
- predicted transmembrane helices (TMHMM): 8
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MKIVAITSCPNGIAHTYMAQEKLEQVAKEMGVDIKVETQGGVGAENVLTTQDIEEADGVIIAADKQVDLSRFVGKRLINENVREGIHNPRGLIQRIINQDAPIYQSETNYHSKDRGKSKSGIQMVYQHLMNGVSFMVPFIVVGGLLIAIALTLGGETTSKGLVIPDDSFWKSIENIGSLAFKFMVPILAGYIAVSIADKPGLVPGMIGGAIAADGSFYGSDAGAGFLGGIVAGFLAGYIAKWIKDIKVPKAMAPIMPIIIIPIISSVVVGLIFIFLIGAPISNIFEALTTWLKSMQGANIIILAMIIGAMIAFDMGGPVNKVAFLFGSALIAEGNYAVMGMVAVAVCTPPIGLGLATFVQKYKFNHSEREMGKASFTMGLFGITEGAIPFAAQDPLRIIPANIIGAMIASVIAAIGGVGDRVAHGGPIVAVLGGIDHVLWFIFAVIVGSLVTMTTVLLLKRNTPVIAVDAPAQHTQLHDTDITQHDTEVDNVDKTAKHSHLNKPSHVFDQQTMIITDHDMSRNEAIDMLIHKLKICRYVEHTSHLKNAILEREMESTTAIGMNVAIPHAKSDVVKQPIVAVMKNNHGVKWDSLDGSLPQLIFLIAVPNNSQDTHLKILQRLSKALMNDETRQSLINANSTTEIYNLLMKI
⊟Experimental data[edit | edit source]
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator: ManR, CcpA see SA2434
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: data available for NCTC8325
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
- Aureolib: no data available
⊟Protein stability[edit | edit source]
- half-life: no data available
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ R Allyn Forsyth, Robert J Haselbeck, Kari L Ohlsen, Robert T Yamamoto, Howard Xu, John D Trawick, Daniel Wall, Liangsu Wang, Vickie Brown-Driver, Jamie M Froelich, Kedar G C, Paula King, Melissa McCarthy, Cheryl Malone, Brian Misiner, David Robbins, Zehui Tan, Zhan-yang Zhu Zy, Grant Carr, Deborah A Mosca, Carlos Zamudio, J Gordon Foulkes, Judith W Zyskind
A genome-wide strategy for the identification of essential genes in Staphylococcus aureus.
Mol Microbiol: 2002, 43(6);1387-400
[PubMed:11952893] [WorldCat.org] [DOI] (P p)