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NCBI: 02-MAR-2017

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus N315
  • locus tag: SA_RS11520 [old locus tag: SA2001 ]
  • pan locus tag?: SAUPAN005606000
  • symbol: SA_RS11520
  • pan gene symbol?: —
  • synonym:
  • product: aldo/keto reductase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SA_RS11520 [old locus tag: SA2001 ]
  • symbol: SA_RS11520
  • product: aldo/keto reductase
  • replicon: chromosome
  • strand: -
  • coordinates: 2271851..2272699
  • length: 849
  • essential: no DEG other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_002745 (2271851..2272699) NCBI
  • BioCyc: SA_RS11520 BioCyc
  • MicrobesOnline: see SA2001

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGAATCATATTGAAATAAGTAAAGATGTAAAGATACCAGTATTAGGTTTCGGAGTATTT
    CAAATTCCTCAAGAACAAACAGCAGAAGCGGTTAAAGAAGCAATTAAAGCGGGTTATAGA
    CATATTGATACAGCACAAAGTTATTTAAATGAAACTGAAGTAGGTCAAGGTATTGAAGCT
    TCAGGTATTGATAGAAGTGAACTATTCATTACGACTAAAGTATGGATTGAAAATGTTAAC
    TATGAAGATACTATCAAATCAATCGAACGATCATTACAACGATTAAATTTGGACTATCTT
    GATCTAGTGCTTATTCACCAACCTTACAATGACGTATATGGCTCATGGCGTGCATTAGAA
    GAGTTAAAAGAAAATGGTAAAATTAAAGCAATCGGTGTATCTAACTTCGGCGTTGATCGA
    ATTGTAGATTTAGGTATTCACAATCAAATTCAACCACAAGTGAACCAAATAGAAATTAAT
    CCATTCCATCAACAAGAAGAACAAGTTGCAGCACTTCAACAAGAAAATGTTGTGGTAGAA
    GCTTGGGCACCATTTGCAGAAGGTAAAAATCAATTATTCCAAAATCAATTGTTGCAGGCC
    ATTGCAGATAAATACAACAAATCAATTGCACAAGTTATTTTACGCTGGTTAGTAGAACGT
    GACATTGTTGTACTCGCAAAATCAGTGAATCCAGAACGTATGGCTCAAAACTTAGATATA
    TTTGATTTTGAACTTACAGAAGAAGATAAACAACAAATTGCGACATTAGAAGAAAGTAAT
    AGCCAATTTTTCTCACATGCTGATCCAGAGATGATTAAAGCACTTACAAGCAGAGAATTA
    GATGTTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    849

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SA_RS11520 [old locus tag: SA2001 ]
  • symbol: SA_RS11520
  • description: aldo/keto reductase
  • length: 282
  • theoretical pI: 4.38261
  • theoretical MW: 32202
  • GRAVY: -0.336525

⊟Function[edit | edit source]

  • TIGRFAM:
    voltage-dependent potassium channel beta subunit (TIGR01293; HMM-score: 47.3)
  • TheSEED: see SA2001
  • PFAM:
    no clan defined Aldo_ket_red; Aldo/keto reductase family (PF00248; HMM-score: 180.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.105534
    • TAT(Tat/SPI): 0.007155
    • LIPO(Sec/SPII): 0.001178
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MNHIEISKDVKIPVLGFGVFQIPQEQTAEAVKEAIKAGYRHIDTAQSYLNETEVGQGIEASGIDRSELFITTKVWIENVNYEDTIKSIERSLQRLNLDYLDLVLIHQPYNDVYGSWRALEELKENGKIKAIGVSNFGVDRIVDLGIHNQIQPQVNQIEINPFHQQEEQVAALQQENVVVEAWAPFAEGKNQLFQNQLLQAIADKYNKSIAQVILRWLVERDIVVLAKSVNPERMAQNLDIFDFELTEEDKQQIATLEESNSQFFSHADPEMIKALTSRELDV

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:
    SA_RS0021550S ribosomal protein L9  [1] (data from MRSA252)
    SA_RS01275formate acetyltransferase  [1] (data from MRSA252)
    SA_RS01960acetyl-CoA acyltransferase  [1] (data from MRSA252)
    SA_RS0291050S ribosomal protein L1  [1] (data from MRSA252)
    SA_RS02960elongation factor Tu  [1] (data from MRSA252)
    SA_RS03155phosphate acetyltransferase  [1] (data from MRSA252)
    SA_RS04025preprotein translocase subunit SecA  [1] (data from MRSA252)
    SA_RS04140aldehyde dehydrogenase  [1] (data from MRSA252)
    SA_RS05350pyruvate dehydrogenase E1 component subunit alpha  [1] (data from MRSA252)
    SA_RS05360dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex  [1] (data from MRSA252)
    SA_RS05365dihydrolipoyl dehydrogenase  [1] (data from MRSA252)
    SA_RS05860cell division protein FtsZ  [1] (data from MRSA252)
    SA_RS0622530S ribosomal protein S2  [1] (data from MRSA252)
    SA_RS07385DNA-binding protein HU  [1] (data from MRSA252)
    SA_RS0798530S ribosomal protein S20  [1] (data from MRSA252)
    SA_RS0829550S ribosomal protein L21  [1] (data from MRSA252)
    SA_RS08545isocitrate dehydrogenase (NADP(+))  [1] (data from MRSA252)
    SA_RS08600universal stress protein  [1] (data from MRSA252)
    SA_RS08630acetate kinase  [1] (data from MRSA252)
    SA_RS11245glutamine--fructose-6-phosphate aminotransferase  [1] (data from MRSA252)
    SA_RS11430Asp23/Gls24 family envelope stress response protein  [1] (data from MRSA252)
    SA_RS1160030S ribosomal protein S9  [1] (data from MRSA252)
    SA_RS1160550S ribosomal protein L13  [1] (data from MRSA252)
    SA_RS1163050S ribosomal protein L17  [1] (data from MRSA252)
    SA_RS1167050S ribosomal protein L15  [1] (data from MRSA252)
    SA_RS1169050S ribosomal protein L6  [1] (data from MRSA252)
    SA_RS1173530S ribosomal protein S3  [1] (data from MRSA252)

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 1.20 1.21 1.22 1.23 1.24 1.25 1.26 Artem Cherkasov, Michael Hsing, Roya Zoraghi, Leonard J Foster, Raymond H See, Nikolay Stoynov, Jihong Jiang, Sukhbir Kaur, Tian Lian, Linda Jackson, Huansheng Gong, Rick Swayze, Emily Amandoron, Farhad Hormozdiari, Phuong Dao, Cenk Sahinalp, Osvaldo Santos-Filho, Peter Axerio-Cilies, Kendall Byler, William R McMaster, Robert C Brunham, B Brett Finlay, Neil E Reiner
    Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus.
    J Proteome Res: 2011, 10(3);1139-50
    [PubMed:21166474] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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