PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 02-MAR-2017

⊟Summary

• organism: Staphylococcus aureus N315
• locus tag: SA_RS10420 [old locus tag: SA1814 ]
• pan locus tag^?: SAUPAN005193000
• symbol: SA_RS10420
• pan gene symbol^?: —
• synonym:
• product: succinyl-diaminopimelate desuccinylase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SA_RS10420 [old locus tag: SA1814 ]
• symbol: SA_RS10420
• product: succinyl-diaminopimelate desuccinylase
• replicon: chromosome
• strand: +
• coordinates: 2053168..2054391
• length: 1224
• essential: no DEG other strains

⊟Accession numbers

• Location: NC_002745 (2053168..2054391) NCBI
• BioCyc: SA_RS10420 BioCyc
• MicrobesOnline: see SA1814

⊟Phenotype

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⊟DNA sequence

• 1
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  ATGACAACTTTTAGTGAAAAAGAAAAAATTCAATTACTAGCAGATATTGTTGAACTACAA
  ACTGAAAATAATAATGAAATAGACGTTTGTAATTATTTAAAAGATTTATTCGACAAGTAC
  GATATTAAATCTGAAATTTTGAAAGTTAATGAACACCGCGCCAATATCGTTGCAGAAATC
  GGTAACGGCTCACCTATACTCGCATTGAGTGGTCATATGGATGTTGTTGATGCAGGAAAT
  CAAGATAATTGGACTTATCCCCCTTTTCAACTCACAGAAAAAGCTGGCAAATTATACGGT
  CGAGGCACAACGGATATGAAAGGCGGTCTGATGGCTTTGGTCATCACACTCATTGAATTA
  AAAGAACAAAATCAATTGCCTCAAGGAACGATAAGATTACTAGCTACTGCTGGCGAAGAG
  AAAGAACAAGAAGGTGCCAAATTATTGGCTGATAAAGGCTATTTAGACGATGTAGATGGC
  TTAATTATTGCTGAACCAACTGGATCTGGAATTTATTATGCACATAAAGGGTCTATGTCA
  TGTAAAGTAACTGCAACTGGCAAAGCTGTCCATAGCTCAGTTCCATTTATTGGTGACAAT
  GCAATTGATACACTGCTTGAATTTTATAATCAATTTAAAGAAAAATATTCAGAGCTTAAA
  AAACATGATACTAAACATGAATTAGATGTTGCACCCATGTTCAAATCATTGATAGGAAAA
  GAAATTTCTGAAGAGGATGCAAATTATGCATCTGGTCTTACAGCTGTATGTTCGATTATA
  AATGGCGGCAAACAATTTAACTCTGTACCAGATGAAGCTTCACTTGAATTTAACGTAAGA
  CCAGTTCCTGAGTATGATAACGACTTTATAGAATCGTTTTTCCAAAATATCATTAATGAT
  GTGGATAGCAATAAGCTTTCACTCGATATTCCAAGCAATCACCGACCTGTAACAAGCGAT
  AAAAATAGCAAATTAATTACTACGATTAAAGATGTAGCTTCTAGTTATGTAGAACAAGAC
  GAAATATTTGTTTCAGCGCTTGTAGGTGCAACAGATGCCTCTAGTTTCTTAGGAGATAAT
  AAGGACAATGTTGATTTAGCCATTTTTGGACCAGGTAATCCATTAATGGCACATCAAATC
  GATGAATATATTGAAAAAGATATGTACCTGAAATATATTGATATTTTTAAAGAGGCTTCC
  ATTCAATATTTAAAAGAGAAATAA
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  1224
  

⊟Protein

⊟General

• locus tag: SA_RS10420 [old locus tag: SA1814 ]
• symbol: SA_RS10420
• description: succinyl-diaminopimelate desuccinylase
• length: 407
• theoretical pI: 4.3768
• theoretical MW: 45136.5
• GRAVY: -0.342506

⊟Function

• reaction:
  EC 3.5.1.18?  ExPASy
  Succinyl-diaminopimelate desuccinylase N-succinyl-LL-2,6-diaminoheptanedioate + H₂O = succinate + LL-2,6-diaminoheptanedioate
• TIGRFAM:
  Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides peptidase, ArgE/DapE family (TIGR01910; EC 3.4.-.-; HMM-score: 301.5)
  and 11 more
  Metabolism Amino acid biosynthesis Glutamate family acetylornithine deacetylase (ArgE) (TIGR01892; EC 3.5.1.16; HMM-score: 171.5)
  Metabolism Amino acid biosynthesis Aspartate family succinyl-diaminopimelate desuccinylase (TIGR01246; EC 3.5.1.18; HMM-score: 132.9)
  Metabolism Amino acid biosynthesis Aspartate family succinyl-diaminopimelate desuccinylase (TIGR01900; EC 3.5.1.18; HMM-score: 122)
  putative selenium metabolism hydrolase (TIGR03526; HMM-score: 117.4)
  N-acetyl-ornithine/N-acetyl-lysine deacetylase (TIGR01902; HMM-score: 104.8)
  putative dipeptidase (TIGR01887; EC 3.4.13.-; HMM-score: 95.9)
  N-acyl-L-amino-acid amidohydrolase (TIGR01880; EC 3.5.1.14; HMM-score: 77.7)
  Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides amidohydrolase (TIGR01891; HMM-score: 77.2)
  Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides dipeptidase PepV (TIGR01886; EC 3.4.13.-; HMM-score: 54.1)
  peptidase T-like protein (TIGR01883; HMM-score: 28.5)
  Xaa-His dipeptidase (TIGR01893; EC 3.4.13.20; HMM-score: 23.2)
• TheSEED: see SA1814
• PFAM:
  ZnExoPePases (CL0865) Peptidase_M20; Peptidase family M20/M25/M40 (PF01546; HMM-score: 133.3)
  and 2 more
  no clan defined M20_dimer; Peptidase dimerisation domain (PF07687; HMM-score: 80.3)
  ZnExoPePases (CL0865) Peptidase_M28; Peptidase family M28 (PF04389; HMM-score: 30.2)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors: Co²⁺, Zn²⁺
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9679
  • Cytoplasmic Membrane Score: 0.0221
  • Cell wall & surface Score: 0.0028
  • Extracellular Score: 0.0071
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.003526
  • TAT(Tat/SPI): 0.000135
  • LIPO(Sec/SPII): 0.000497
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 446128770 NCBI
• RefSeq: WP_000206625 NCBI
• UniProt: see SA1814

⊟Protein sequence

• MTTFSEKEKIQLLADIVELQTENNNEIDVCNYLKDLFDKYDIKSEILKVNEHRANIVAEIGNGSPILALSGHMDVVDAGNQDNWTYPPFQLTEKAGKLYGRGTTDMKGGLMALVITLIELKEQNQLPQGTIRLLATAGEEKEQEGAKLLADKGYLDDVDGLIIAEPTGSGIYYAHKGSMSCKVTATGKAVHSSVPFIGDNAIDTLLEFYNQFKEKYSELKKHDTKHELDVAPMFKSLIGKEISEEDANYASGLTAVCSIINGGKQFNSVPDEASLEFNVRPVPEYDNDFIESFFQNIINDVDSNKLSLDIPSNHRPVTSDKNSKLITTIKDVASSYVEQDEIFVSALVGATDASSFLGDNKDNVDLAIFGPGNPLMAHQIDEYIEKDMYLKYIDIFKEASIQYLKEK

⊟Experimental data

• experimentally validated: data available for NCTC8325
• protein localization:
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for COL, JSNZ, NCTC8325, Newman

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications