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NCBI: 02-MAR-2017

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus N315
  • locus tag: SA_RS08780 [old locus tag: SA1557 ]
  • pan locus tag?: SAUPAN004400000
  • symbol: SA_RS08780
  • pan gene symbol?: ccpA
  • synonym:
  • product: catabolite control protein A

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SA_RS08780 [old locus tag: SA1557 ]
  • symbol: SA_RS08780
  • product: catabolite control protein A
  • replicon: chromosome
  • strand: -
  • coordinates: 1784194..1785183
  • length: 990
  • essential: yes DEG other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_002745 (1784194..1785183) NCBI
  • BioCyc: SA_RS08780 BioCyc
  • MicrobesOnline: see SA1557

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGACAGTTACTATATATGATGTAGCAAGAGAAGCGCGTGTCTCTATGGCCACAGTGTCG
    CGTGTTGTTAATGGGAACCAAAATGTTAAAGCAGAAACTAAAAATAAAGTTAACGAAGTC
    ATTAAGCGTTTGAATTATCGTCCAAATGCTGTTGCTAGAGGTTTAGCTAGTAAAAAGACA
    ACAACAGTAGGTGTGATCATTCCAGATATATCTAATATCTATTATTCACAACTTGCTCGT
    GGACTTGAAGATATTGCAACAATGTATAAATATCACTCAATTATTTCAAATTCAGATAAC
    GATCCTGAAAAGGAAAAAGAAATTTTTAATAACTTATTAAGTAAACAGGTTGATGGTATT
    ATTTTCCTTGGTGGTACAATTACTGAAGAAATGAAAGAATTGATAAATCAATCATCTGTA
    CCTGTAGTAGTATCAGGAACAAATGGTAAGGATGCACATATAGCATCAGTTAATATTGAT
    TTTACTGAAGCTGCGAAAGAAATTACGGGAGAATTAATTGAAAAAGGCGCTAAATCATTT
    GCTTTAGTAGGTGGAGAACATTCTAAAAAAGCTCAAGAAGATGTTTTAGAAGGTTTAACT
    GAAGTGTTAAATAAAAATGGCCTTCAATTAGGTGATACATTGAATTGTTCTGGTGCTGAA
    AGTTATAAAGAAGGCGTAAAAGCTTTTGCTAAAATGAAAGGCAATTTGCCAGATGCCATT
    TTATGTATCAGCGACGAAGAAGCAATTGGTATTATGCATAGTGCAATGGATGCTGGTATT
    AAAGTTCCAGAGGAATTACAAATTATTAGTTTCAATAATACACGATTAGTTGAGATGGTT
    AGACCACAACTTTCTAGTGTTATTCAACCATTATATGATATCGGTGCAGTAGGGATGCGC
    TTATTAACAAAATATATGAACGATGAAAAGATAGAAGAACCAAATGTAGTTTTACCTCAC
    AGAATTGAATACCGAGGAACTACAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    990

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SA_RS08780 [old locus tag: SA1557 ]
  • symbol: SA_RS08780
  • description: catabolite control protein A
  • length: 329
  • theoretical pI: 5.50763
  • theoretical MW: 36060
  • GRAVY: -0.229787

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Signal transduction Regulatory functions DNA interactions catabolite control protein A (TIGR01481; HMM-score: 570.3)
    and 5 more
    Signal transduction Regulatory functions DNA interactions D-fructose-responsive transcription factor (TIGR02417; HMM-score: 159)
    Signal transduction Regulatory functions DNA interactions trehalose operon repressor (TIGR02405; HMM-score: 107.1)
    Genetic information processing Mobile and extrachromosomal element functions Other addiction module antidote protein, HigA family (TIGR02607; HMM-score: 18.6)
    Signal transduction Regulatory functions DNA interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 18.6)
    Signal transduction Regulatory functions Protein interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 18.6)
  • TheSEED: see SA1557
  • ⊞PFAM:
    Periplas_BP (CL0144) Peripla_BP_3; Periplasmic binding protein-like domain (PF13377; HMM-score: 98.4)
    and 11 more
    Peripla_BP_1; Periplasmic binding proteins and sugar binding domain of LacI family (PF00532; HMM-score: 73.5)
    Peripla_BP_4; Periplasmic binding protein domain (PF13407; HMM-score: 72.6)
    HTH (CL0123) LacI; Bacterial regulatory proteins, lacI family (PF00356; HMM-score: 67.2)
    MurF-HprK_N (CL0365) Hpr_kinase_N; HPr Serine kinase N terminus (PF02603; HMM-score: 15.4)
    4Fe-4S (CL0344) Fer4_12; 4Fe-4S single cluster domain (PF13353; HMM-score: 15.4)
    no clan defined ATP-synt_F; ATP synthase (F/14-kDa) subunit (PF01990; HMM-score: 14.8)
    DUF327; Protein of unknown function (DUF327) (PF03885; HMM-score: 14.8)
    NADP_Rossmann (CL0063) CoA_binding_2; CoA binding domain (PF13380; HMM-score: 14.7)
    HTH (CL0123) HTH_31; Helix-turn-helix domain (PF13560; HMM-score: 13.5)
    HTH_3; Helix-turn-helix (PF01381; HMM-score: 12.6)
    HTH_26; Cro/C1-type HTH DNA-binding domain (PF13443; HMM-score: 12.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by CcpA, TF important in Carbon catabolism: see SA1557

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • ⊞DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9736
    • Cytoplasmic Membrane Score: 0.0213
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.005
  • LocateP:
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.027924
    • TAT(Tat/SPI): 0.004638
    • LIPO(Sec/SPII): 0.00505
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTVTIYDVAREARVSMATVSRVVNGNQNVKAETKNKVNEVIKRLNYRPNAVARGLASKKTTTVGVIIPDISNIYYSQLARGLEDIATMYKYHSIISNSDNDPEKEKEIFNNLLSKQVDGIIFLGGTITEEMKELINQSSVPVVVSGTNGKDAHIASVNIDFTEAAKEITGELIEKGAKSFALVGGEHSKKAQEDVLEGLTEVLNKNGLQLGDTLNCSGAESYKEGVKAFAKMKGNLPDAILCISDEEAIGIMHSAMDAGIKVPEELQIISFNNTRLVEMVRPQLSSVIQPLYDIGAVGMRLLTKYMNDEKIEEPNVVLPHRIEYRGTTK

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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