PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 02-MAR-2017

⊟Summary

• organism: Staphylococcus aureus N315
• locus tag: SA_RS05630 [old locus tag: SA0993 ]
• pan locus tag^?: SAUPAN003385000
• symbol: SA_RS05630
• pan gene symbol^?: uvrC
• synonym:
• product: excinuclease ABC subunit C

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SA_RS05630 [old locus tag: SA0993 ]
• symbol: SA_RS05630
• product: excinuclease ABC subunit C
• replicon: chromosome
• strand: +
• coordinates: 1125255..1127036
• length: 1782
• essential: yes DEG other strains

⊟Accession numbers

• Location: NC_002745 (1125255..1127036) NCBI
• BioCyc: SA_RS05630 BioCyc
• MicrobesOnline: see SA0993

⊟Phenotype

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⊟DNA sequence

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  TTGGAAGACTATAAGCAACGAATTAAAAATAAATTAAATGTCGTACCTATGGAACCAGGC
  TGCTATTTAATGAAAGATCGTAATGATCAAGTGATATATGTTGGCAAAGCTAAAAAGCTA
  AGAAATCGATTGAGATCATATTTTACGGGTGCTCATGATGCTAAAACAACGAGACTGGTT
  GGTGAAATACGTCGTTTTGAGTTTATTGTCACGTCAAGTGAAACAGAGTCACTTTTACTG
  GAATTGAATCTGATAAAACAATATCAACCAAGATATAATATATTATTAAAGGATGATAAA
  AGTTATCCATTTATTAAAATTACGAAGGAGAAATATCCTAGACTACTAGTGACGAGAACT
  GTAAAACAAGGTACTGGCAAATATTTCGGACCGTATCCGAATGCATATTCTGCTCAAGAA
  ACTAAAAAGTTATTAGACAGAATATATCCATATCGCAAATGTGATAAGATGCCAGATAAA
  TTATGTCTTTATTACCATATTGGACAATGTTTAGGACCATGTGTATATGACGTTGATTTG
  AGTAAATACGCACAAATGACGAAGGAAATTACTGATTTTCTGAATGGGGAAGACAAAACA
  ATTTTAAAAAGTTTAGAAGAGCGAATGTTAACTGCAAGTGAATCACTTGATTTTGAACGG
  GCTAAAGAATATAGAGATTTAATTCAACATATTCAAAATCTGACAAACAAACAAAAAATT
  ATGTCATCAGATAAAACGATTCGTGATGTCTTTGGTTATTGTGTTGATAAAGGATGGATG
  TGTATCCAAGTTTTCTTTATACGACAAGGTAATATGATAAAGCGAGATACAACGATGATT
  CCATTACAGCAAACAGAAGAAGAAGAATTTTATACATTTATTGGACAATTTTATAGCTTA
  AACCAACATATTTTACCTAAGGAAGTTCATGTACCACGTAATTTGGATAAAGAAATGATT
  CAATCTGTTGTGGACACTAAAATCGTTCAACCCGCGCGAGGTCCCAAAAAAGATATGGTT
  GACCTAGCTGCACATAACGCTAAAGTATCCTTAAATAATAAATTTGAATTAATATCACGT
  GATGAGTCAAGAACGATTAAAGCTATTGAAGAACTTGGAACACAAATGGGAATTCAAACA
  CCAATTAGAATTGAAGCATTCGATAATTCTAATATTCAAGGTGTGGATCCAGTGTCAGCA
  ATGGTTACATTTGTCGACGGTAAACCAGATAAGAAAAATTATAGAAAGTATAAAATCAAA
  ACGGTTAAAGGTCCAGATGATTACAAATCAATGAGAGAAGTAGTAAGACGACGATATTCT
  CGCGTTTTAAACGAAGGATTACCATTACCTGATTTAATAATAGTCGATGGTGGTAAAGGA
  CATATGAACGGGGTTATTGATGTGCTACAAAACGAATTAGGTCTTGATATCCCTGTTGCA
  GGTTTGCAGAAAAATGATAAACACCAAACATCTGAATTATTATATGGCGCTAGTGCAGAA
  ATTGTACCACTGAAGAAAAATAGCCAGGCATTTTATTTGTTGCATCGTATCCAAGATGAG
  GTTCACAGATTCGCAATCACATTTCATAGACAAACACGTCAAAAGACAGGCTTGAAATCA
  ATACTTGATGATATAGATGGTATCGGTAACAAACGTAAAACATTATTATTGCGTTCATTC
  GGTTCAATCAAGAAAATGAAGGAAGCTACACTTGAAGATTTTAAAAATATAGGTATTCCT
  GAAAACGTCGCAAAGAACCTACATGAACAATTGCATAAATAA
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⊟Protein

⊟General

• locus tag: SA_RS05630 [old locus tag: SA0993 ]
• symbol: SA_RS05630
• description: excinuclease ABC subunit C
• length: 593
• theoretical pI: 9.74886
• theoretical MW: 68687
• GRAVY: -0.571669

⊟Function

• TIGRFAM:
  Genetic information processing DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit C (TIGR00194; EC 3.1.25.-; HMM-score: 660)
  and 1 more
  group I intron endonuclease (TIGR01453; HMM-score: 13.6)
• TheSEED: see SA0993
• PFAM:
  Endonuclease (CL0189) UvrC_HhH_N; UvrC Helix-hairpin-helix N-terminal (PF08459; HMM-score: 179.3)
  and 4 more
  GIY-YIG (CL0418) GIY-YIG; GIY-YIG catalytic domain (PF01541; HMM-score: 44.9)
  no clan defined UVR; UvrB/uvrC motif (PF02151; HMM-score: 40)
  HHH (CL0198) HHH_2; Helix-hairpin-helix motif (PF12826; HMM-score: 18.4)
  no clan defined DUF3936; Protein of unknown function (DUF3936) (PF13072; HMM-score: 12.1)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.00368
  • TAT(Tat/SPI): 0.000393
  • LIPO(Sec/SPII): 0.001302
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 446312669 NCBI
• RefSeq: WP_000390524 NCBI
• UniProt: see SA0993

⊟Protein sequence

• MEDYKQRIKNKLNVVPMEPGCYLMKDRNDQVIYVGKAKKLRNRLRSYFTGAHDAKTTRLVGEIRRFEFIVTSSETESLLLELNLIKQYQPRYNILLKDDKSYPFIKITKEKYPRLLVTRTVKQGTGKYFGPYPNAYSAQETKKLLDRIYPYRKCDKMPDKLCLYYHIGQCLGPCVYDVDLSKYAQMTKEITDFLNGEDKTILKSLEERMLTASESLDFERAKEYRDLIQHIQNLTNKQKIMSSDKTIRDVFGYCVDKGWMCIQVFFIRQGNMIKRDTTMIPLQQTEEEEFYTFIGQFYSLNQHILPKEVHVPRNLDKEMIQSVVDTKIVQPARGPKKDMVDLAAHNAKVSLNNKFELISRDESRTIKAIEELGTQMGIQTPIRIEAFDNSNIQGVDPVSAMVTFVDGKPDKKNYRKYKIKTVKGPDDYKSMREVVRRRYSRVLNEGLPLPDLIIVDGGKGHMNGVIDVLQNELGLDIPVAGLQKNDKHQTSELLYGASAEIVPLKKNSQAFYLLHRIQDEVHRFAITFHRQTRQKTGLKSILDDIDGIGNKRKTLLLRSFGSIKKMKEATLEDFKNIGIPENVAKNLHEQLHK

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications