PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 02-MAR-2017

⊟Summary

• organism: Staphylococcus aureus N315
• locus tag: SA_RS00210 [old locus tag: SA0013 ]
• pan locus tag^?: SAUPAN000024000
• symbol: SA_RS00210
• pan gene symbol^?: gdpP
• synonym:
• product: DHH family phosphoesterase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SA_RS00210 [old locus tag: SA0013 ]
• symbol: SA_RS00210
• product: DHH family phosphoesterase
• replicon: chromosome
• strand: +
• coordinates: 18328..20295
• length: 1968
• essential: no DEG other strains

⊟Accession numbers

• Location: NC_002745 (18328..20295) NCBI
• BioCyc: SA_RS00210 BioCyc
• MicrobesOnline: see SA0013

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
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  841
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  1021
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  1141
  1201
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  1321
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  1561
  1621
  1681
  1741
  1801
  1861
  1921
  
  ATGAATCGGCAGTCCACTAAGAAAGCTTTACTAATACCATTTGTCATCATGATCATCACA
  GCAATTGTTTTAATGGGTGTATGGTTTATCTTTAATAGTCTTATAGCATTAATTGCATCT
  ATCGTTCTTGTCGTGATGATTATTGTTAGCATCATTTTATTCAGACAAGCTTTAATGAAA
  ATGGATAGTTATGTAGATGGTTTGAGTGCTCAAATTTCAACAACAAATAATAAAGCAATC
  AAACATTTACCAATTGGTATCATTGTTTTAGATGAAAATGATCACATCGAATGGGTTAAC
  CAATTTATGACAAATCATATGGAAGCAAATGTCATTTCTGAATCTGTAAATGAAGTATTT
  CCAAACATTTTAAAGCAATTAGATAGAGTGAAATCCGTTGAAATAGAATATAATCAGTAT
  CATTTCCAAGTACGTTATTCTGAGAATGATCATTGCCTCTATTTCTTTGATATAACTGAA
  CAAGTACAAACAAATGAACTATATGAAAATTCTAAACCAATCATTGCGACATTATTTTTA
  GATAACTACGATGAGATTACTCAAAATATGAATGATACGCAGCGTTCGGAAATCAATTCA
  ATGGTAACGCGTGTTATTAGTCGATGGGCAACTGAGTATAATATATTCTTTAAAAGGTAT
  AGTTCCGATCAATTCGTAGCCTATTTAAATCAAAAAATATTAGCTGACTTAGAAGAATCT
  AAATTTGATATCTTGAGTCAATTACGTGAAAAAAGTGTTGGTTATCGTGCCCAATTAACA
  TTAAGTATTGGTGTTGGTGAAGGTACTGAAAATTTAATCGATTTAGGTGAATTATCACAA
  TCAGGCCTAGACTTAGCATTAGGGCGCGGTGGCGACCAAGTTGCAATTAAAAGTATTAAT
  GGTAATGTGCGTTTCTATGGCGGTAAGACTGACCCGATGGAGAAACGTACTCGTGTAAGA
  GCACGAGTGATCTCACATGCGTTAAAAGATATCCTTGCAGAGGGTGACAAAGTCATTATC
  ATGGGACATAAACGTCCTGACTTAGATGCAATTGGTGCAGCAATCGGTGTGTCTAGATTT
  GCAATGATGAATAATTTAGAAGCATACATCGTATTAAATGAGACTGACATTGATCCAACA
  TTACGACGCGTGATGAACGAAATTGATAAAAAGTCAGAGTTAAGAGAGCGATTTATAACA
  TCAGATGATGCTTGGGATATGATGACATCTAAGACAACCGTAGTGATTGTTGATACGCAT
  AAACCGGAACTGGTTTTAGATGAAAATGTCTTAAATAAAGCAAACCGTAAAGTTGTTATC
  GATCATCATAGACGTGGTGAAAGCTTCATCTCTAATCCATTGTTGATATATATGGAACCA
  TACGCAAGTTCAACAGCTGAATTGGTAACAGAGTTACTGGAATATCAACCAACAGAACAA
  CGTTTAACACGTCTTGAATCAACAGTGATGTATGCAGGTATTATTGTAGATACAAGAAAC
  TTTACATTACGAACAGGATCAAGAACATTCGATGCAGCGAGTTATTTACGTGCACATGGT
  GCAGATACGATTTTAACGCAACATTTCTTAAAAGATGATGTGGATACTTACATTAATCGA
  TCTGAATTAATTCGAACTGTAAAAGTTGAAGATAATGGCATAGCCATTGCGCATGGTTCA
  GACGATAAAATTTATCATCCAGTAACAGTTGCACAAGCAGCAGATGAACTGTTAAGTTTA
  GAAGGTATTGAAGCATCATATGTTGTTGCGAGACGTGAAGATAATCTGATTGGTATATCT
  GCGCGTTCACTCGGTTCAGTAAATGTTCAGTTAACAATGGAAGCACTTGGTGGCGGTGGA
  CATTTAACCAATGCTGCAACACAACTTAAAGGTGTGACAGTCGAAGAGGCGATAGCACAA
  TTACAACAAGCAATTACAGAACAATTAAGTAGGAGTGAAGATGCATGA
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  1860
  1920
  1968
  

⊟Protein

⊟General

• locus tag: SA_RS00210 [old locus tag: SA0013 ]
• symbol: SA_RS00210
• description: DHH family phosphoesterase
• length: 655
• theoretical pI: 4.94427
• theoretical MW: 73769.6
• GRAVY: -0.109008

⊟Function

• TIGRFAM:
  Signal transduction Signal transduction Two-component systems phosphate regulon sensor kinase PhoR (TIGR02966; EC 2.7.3.-; HMM-score: 17.8)
• TheSEED: see SA0013
• PFAM:
  HAD (CL0137) DHH; DHH family (PF01368; HMM-score: 79.1)
  and 7 more
  no clan defined DHHA1; DHHA1 domain (PF02272; HMM-score: 45.6)
  PAS_Fold (CL0183) PAS_8; PAS domain (PF13188; HMM-score: 15.3)
  TPR (CL0020) API5; Apoptosis inhibitory protein 5 (API5) (PF05918; HMM-score: 13.3)
  no clan defined PrgI; PrgI family protein (PF12666; HMM-score: 11.3)
  RseC_MucC; Positive regulator of sigma(E), RseC/MucC (PF04246; HMM-score: 9.8)
  DUF948; Bacterial protein of unknown function (DUF948) (PF06103; HMM-score: 7.5)
  TMEM100; Transmembrane protein 100 (PF16311; HMM-score: 6.3)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 2
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.001127
  • TAT(Tat/SPI): 0.000712
  • LIPO(Sec/SPII): 0.009726
• predicted transmembrane helices (TMHMM): 2

⊟Accession numbers

• GI: 447004384 NCBI
• RefSeq: WP_001081640 NCBI
• UniProt: see SA0013

⊟Protein sequence

• MNRQSTKKALLIPFVIMIITAIVLMGVWFIFNSLIALIASIVLVVMIIVSIILFRQALMKMDSYVDGLSAQISTTNNKAIKHLPIGIIVLDENDHIEWVNQFMTNHMEANVISESVNEVFPNILKQLDRVKSVEIEYNQYHFQVRYSENDHCLYFFDITEQVQTNELYENSKPIIATLFLDNYDEITQNMNDTQRSEINSMVTRVISRWATEYNIFFKRYSSDQFVAYLNQKILADLEESKFDILSQLREKSVGYRAQLTLSIGVGEGTENLIDLGELSQSGLDLALGRGGDQVAIKSINGNVRFYGGKTDPMEKRTRVRARVISHALKDILAEGDKVIIMGHKRPDLDAIGAAIGVSRFAMMNNLEAYIVLNETDIDPTLRRVMNEIDKKSELRERFITSDDAWDMMTSKTTVVIVDTHKPELVLDENVLNKANRKVVIDHHRRGESFISNPLLIYMEPYASSTAELVTELLEYQPTEQRLTRLESTVMYAGIIVDTRNFTLRTGSRTFDAASYLRAHGADTILTQHFLKDDVDTYINRSELIRTVKVEDNGIAIAHGSDDKIYHPVTVAQAADELLSLEGIEASYVVARREDNLIGISARSLGSVNVQLTMEALGGGGHLTNAATQLKGVTVEEAIAQLQQAITEQLSRSEDA

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications