PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 10-JUN-2013

⊟Summary

• organism: Staphylococcus aureus USA300_FPR3757
• locus tag: SAUSA300_1691 [new locus tag: SAUSA300_RS09240 ]
• pan locus tag^?: SAUPAN004412000
• symbol: SAUSA300_1691
• pan gene symbol^?: —
• synonym:
• product: glutamyl-aminopeptidase

⊟Additional information (user-provided)

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SAUSA300_1691 [new locus tag: SAUSA300_RS09240 ]
• symbol: SAUSA300_1691
• product: glutamyl-aminopeptidase
• replicon: chromosome
• strand: -
• coordinates: 1865402..1866478
• length: 1077
• essential: unknown other strains

⊟Accession numbers

• Gene ID: 3914211 NCBI
• RefSeq: YP_494385 NCBI
• BioCyc: see SAUSA300_RS09240
• MicrobesOnline: 1293206 MicrobesOnline

⊟Phenotype

⊟Additional information (user-provided)

⊟DNA sequence

• 1
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  1021
  
  ATGAACATAAATAAAAAAGTAACATTACAACGAATTCAAACTTTAACTGAGCTTCATGGG
  GCACCAGGTTTTGAAGAAGAAGTAAAAAATTATATGACTCAGCAAATGGCGCCGTACGTA
  GATGAATTTATTGAAAATCGTATGGGTGGATTTTTTGGTGTGAAAAAATCTAAAAATCCA
  AATGCAAAACGTGTAATGATTGCAGCACATATGGATGAAATCGGATTTATGATTACAAAT
  ATCACTAAAAATGGAATGATTCAATTCACAAATTTAGGTGGTGTTGCAAATGATATTTGG
  CAAGGACAACGCTTAGTAATTAAAAATAGAAATGGCGATAAAATTATCGGTGTTGTTTCT
  AATATACCTAAACATTTTCGTACTGGTAGTGAAGGTGCACCGGAAATTAAAGATTTAACA
  TTAGATATAGGTGCTCAAAATGAAGATGAGGTGCGTGAGCGCGGAATAGATATAGGAGAT
  ACAATTGTACCTCACACGCCATTCACACAGTTATCTGAACATCGATATAGTGCTAAAGCA
  TGGGATAATCGTTATGGTTGTGTCTTGGCAATTGAAATACTAGAATTATTAAAAGATATA
  GAATTAGATGTAGACTTGTATGTTGGCGCAAATGTTCAAGAAGAGGTTGGATTACGAGGT
  GCGAAAGCATCTGCAGAGATGATAGACCCAGACGTTGCATTTGTAGTTGATTGTTCACCT
  GCCAATGACGTTAAAGGAAACCAACCATTATCTGGTGAACTTGGTAAAGGGACGTTAATT
  CGCATAAAAGACGGTACAATGATTTTAAAGCCTGTATTTAGAGACTATTTATTAAAGTTA
  GTAGAAGCACATGACATTGAACATCAATACTATATGTCACCAGGTGGAACAGATGGTGGA
  GAAATTCATAAAGCTAATATTGGTATTCCGACTGCAGTTATTGGTGTATGTGCACGATAT
  ATTCATAGTACAGACTCAGTATTTGATATAAGAGACTATTTTGCAGCTAGATCTTTACTT
  TCAGAAGCCATTTGTAATTTAGATAATAATCAAATAGAAACATTACAATATAAATAA
  60
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  1077
  

⊟Protein

⊟General

• locus tag: SAUSA300_1691 [new locus tag: SAUSA300_RS09240 ]
• symbol: SAUSA300_1691
• description: glutamyl-aminopeptidase
• length: 358
• theoretical pI: 5.15206
• theoretical MW: 39783.1
• GRAVY: -0.267598

⊟Function

• reaction:
  EC 3.4.11.7?  ExPASy
  Glutamyl aminopeptidase Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide
• TIGRFAM:
  Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides glutamyl aminopeptidase (TIGR03107; EC 3.4.11.7; HMM-score: 369.3)
  and 1 more
  hydrolase, peptidase M42 family (TIGR03106; HMM-score: 42.2)
• TheSEED  :
  • Deblocking aminopeptidase
  • Glutamyl aminopeptidase (EC 3.4.11.7)
  Protein Metabolism Protein degradation EC 3.4.11.- Aminopeptidases  Glutamyl aminopeptidase (EC 3.4.11.7)
• PFAM:
  ZnExoPePases (CL0865) Peptidase_M42; M42 glutamyl aminopeptidase (PF05343; HMM-score: 330.5)
  and 2 more
  Peptidase_M20; Peptidase family M20/M25/M40 (PF01546; HMM-score: 28.3)
  Peptidase_M28; Peptidase family M28 (PF04389; HMM-score: 22.7)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors: a divalent metal cation
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9855
  • Cytoplasmic Membrane Score: 0.0088
  • Cell wall & surface Score: 0.0001
  • Extracellular Score: 0.0056
• LocateP: Intracellular
  • Prediction by SwissProt Classification: Cytoplasmic
  • Pathway Prediction: No pathway
  • Intracellular possibility: 1
  • Signal peptide possibility: -1
  • N-terminally Anchored Score: 1
  • Predicted Cleavage Site: No CleavageSite
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.008557
  • TAT(Tat/SPI): 0.000655
  • LIPO(Sec/SPII): 0.001089
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 87162362 NCBI
• RefSeq: YP_494385 NCBI
• UniProt: A0A0H2XJ82 UniProt

⊟Additional information (user-provided)

⊟Protein sequence

• MNINKKVTLQRIQTLTELHGAPGFEEEVKNYMTQQMAPYVDEFIENRMGGFFGVKKSKNPNAKRVMIAAHMDEIGFMITNITKNGMIQFTNLGGVANDIWQGQRLVIKNRNGDKIIGVVSNIPKHFRTGSEGAPEIKDLTLDIGAQNEDEVRERGIDIGDTIVPHTPFTQLSEHRYSAKAWDNRYGCVLAIEILELLKDIELDVDLYVGANVQEEVGLRGAKASAEMIDPDVAFVVDCSPANDVKGNQPLSGELGKGTLIRIKDGTMILKPVFRDYLLKLVEAHDIEHQYYMSPGGTDGGEIHKANIGIPTAVIGVCARYIHSTDSVFDIRDYFAARSLLSEAICNLDNNQIETLQYK

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell: data available for COL
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: murC < SAUSA300_1687 < SAUSA300_1688 < SAUSA300_1689 < SAUSA300_1690 < SAUSA300_1691

⊟Regulation

• regulator:

⊟Additional information (user-provided)

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: data available for COL

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Additional information (user-provided)

⊟Other information (user-provided)

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications