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⊟Summary[edit | edit source]
- pan ID?: SAUPAN006364000
- symbol?: arcA
- synonym:
- description?: arginine deiminase
- strand?: -
- coordinates?: 6398954..6400189
- synteny block?: BlockID0050730
- occurrence?: in 100% of 34 strains
arcAc (arcACONS) : constitutive arginine catabolism arginine deiminase [1]
• this version of ArcA is part of the core staphylococcal genome and is found in all strains. It is part of the arginine deiminase pathway that is actively transcribed only during aerobic growth. The "c" after "arcA" is to differentiate this version from the "a" version found in the Arginine Catabolic Metabolic Element (ACME) that sometimes accompanies the SCCmec element in MRSA, particularly the USA300 clade.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2574 (arcA)
08BA02176:
C248_2703 (arcA)
11819-97:
MS7_2640 (arcA)
6850:
RSAU_002478 (adi)
71193:
ST398NM01_2685
ECT-R 2:
ECTR2_2489 (arcA)
ED133:
SAOV_2684c
ED98:
SAAV_2704 (arcA)
HO 5096 0412:
SAEMRSA15_25400 (arcA)
JH1:
SaurJH1_2715
JH9:
SaurJH9_2659
JKD6008:
SAA6008_02694 (arcA)
JKD6159:
SAA6159_02531 (arcA)
JSNZ:
JSNZ_002624 (arcA)
LGA251:
SARLGA251_24070 (arcA)
M013:
M013TW_2616
MRSA252:
SAR2714 (arcA)
MSHR1132:
SAMSHR1132_24590
MSSA476:
SAS2521
Mu3:
SAHV_2619 (arcA)
Mu50:
SAV2635 (arcA)
MW2:
MW2556 (arcA)
RF122:
SAB2510c (arcA)
ST398:
SAPIG2685 (arcA)
T0131:
SAT0131_02901
TCH60:
HMPREF0772_10553 (arcA)
TW20:
SATW20_27730 (arcA)
USA300_TCH1516:
USA300HOU_2635 (arcA3)
VC40:
SAVC_12055
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MTDGPIKVNSEIGALKTVLLKRPGKELENLVPDYLDGLLFDDIPYLEVAQKEHDHFAQVL
N315 MTDGPIKVNSEIGALKTVLLKRPGKELENLVPDYLDGLLFDDIPYLEVAQKEHDHFAQVL
NCTC8325 MTDGPIKVNSEIGALKTVLLKRPGKELENLVPDYLDGLLFDDIPYLEVAQKEHDHFAQVL
Newman MTDGPIKVNSEIGALKTVLLKRPGKELENLVPDYLDGLLFDDIPYLEVAQKEHDHFAQVL
USA300_FPR3757 MTDGPIKVNSEIGALKTVLLKRPGKELENLVPDYLDGLLFDDIPYLEVAQKEHDHFAQVL
************************************************************
COL REEGVEVLYLEKLAAESIENPQVRSEFIDDVLAESKKTILGHEEEIKALFATLSNQELVD
N315 REEGVEVLYLEKLAAESIENPQVRSEFIDDVLAESKKTILGHEEEIKTLFATLSNQELVD
NCTC8325 REEGVEVLYLEKLAAESIENPQVRSEFIDDVLAESKKTILGHEEEIKALFATLSNQELVD
Newman REEGVEVLYLEKLAAESIENPQVRSEFIDDVLAESKKTILGHEEEIKALFATLSNQELVD
USA300_FPR3757 REEGVEVLYLEKLAAESIENPQVRSEFIDDVLAESKKTILGHEEEIKALFATLSNQELVD
***********************************************:************
COL KIMSGVRKEEINPKCTHLVEYMDDKYPFYLDPMPNLYFTRDPQASIGHGITINRMFWRAR
N315 KIMSGVRKEEINPKCTHLVEYMDDKYPFYLDPMPNLYFTRDPQASIGHGITINRMFWRAR
NCTC8325 KIMSGVRKEEINPKCTHLVEYMDDKYPFYLDPMPNLYFTRDPQASIGHGITINRMFWRAR
Newman KIMSGVRKEEINPKCTHLVEYMDDKYPFYLDPMPNLYFTRDPQASIGHGITINRMFWRAR
USA300_FPR3757 KIMSGVRKEEINPKCTHLVEYMDDKYPFYLDPMPNLYFTRDPQASIGHGITINRMFWRAR
************************************************************
COL RRESIFIQYIVKHHPRFKDANIPIWLDRDCPFNIEGGDELVLSKDVLAIGVSERTSAQAI
N315 RRESIFIQYIVKHHPRFKDANIPIWLDRDCPFNIEGGDELVLSKDVLAIGVSERTSAQAI
NCTC8325 RRESIFIQYIVKHHPRFKDANIPIWLDRDCPFNIEGGDELVLSKDVLAIGVSERTSAQAI
Newman RRESIFIQYIVKHHPRFKDANIPIWLDRDCPFNIEGGDELVLSKDVLAIGVSERTSAQAI
USA300_FPR3757 RRESIFIQYIVKHHPRFKDANIPIWLDRDCPFNIEGGDELVLSKDVLAIGVSERTSAQAI
************************************************************
COL EKLARRIFENPQATFKKVVAIEIPTSRTFMHLDTVFTMIDYDKFTMHSAILKAEGNMNIF
N315 EKLARRIFENPQATFKKVVAIEIPTSRTFMHLDTVFTMIDYDKFTMHSAILKAEGNMNIF
NCTC8325 EKLARRIFENPQATFKKVVAIEIPTSRTFMHLDTVFTMIDYDKFTMHSAILKAEGNMNIF
Newman EKLARRIFENPQATFKKVVAIEIPTSRTFMHLDTVFTMIDYDKFTMHSAILKAEGNMNIF
USA300_FPR3757 EKLARRIFENPQATFKKVVAIEIPTSRTFMHLDTVFTMIDYDKFTMHSAILKAEGNMNIF
************************************************************
COL IIEYDDVNKDIAIKQSSHLKDTLEDVLGIDDIQFIPTGNGDVIDGAREQWNDGSNTLCIR
N315 IIEYDDVNKDIAIKQSSHLKDTLEDVLGIDDIQFIPTGNGDVIDGAREQWNDGSNTLCIR
NCTC8325 IIEYDDVNKDIAIKQSSHLKDTLEDVLGIDDIQFIPTGNGDVIDGAREQWNDGSNTLCIR
Newman IIEYDDVNKDIAIKQSSHLKDTLEDVLGIDDIQFIPTGNGDVIDGAREQWNDGSNTLCIR
USA300_FPR3757 IIEYDDVNKDIAIKQSSHLKDTLEDVLGIDDIQFIPTGNGDVIDGAREQWNDGSNTLCIR
************************************************************
COL PGVVVTYDRNYVSNDLLRQKGIKVIEISGSELVRGRGGPRCMSQPLFREDI
N315 PGVVVTYDRNYVSNDLLRQKGIKVIEISGSELVRGRGGPRCMSQPLFREDI
NCTC8325 PGVVVTYDRNYVSNDLLRQKGIKVIEISGSELVRGRGGPRCMSQPLFREDI
Newman PGVVVTYDRNYVSNDLLRQKGIKVIEISGSELVRGRGGPRCMSQPLFREDI
USA300_FPR3757 PGVVVTYDRNYVSNDLLRQKGIKVIEISGSELVRGRGGPRCMSQPLFREDI
***************************************************
- ↑ Julia Makhlin, Tzili Kofman, Ilya Borovok, Christian Kohler, Susanne Engelmann, Gerald Cohen, Yair Aharonowitz
Staphylococcus aureus ArcR controls expression of the arginine deiminase operon.
J Bacteriol: 2007, 189(16);5976-86
[PubMed:17557828] [WorldCat.org] [DOI] (P p)Zayda Lorena Corredor Rozo, Ricaurte Alejandro Márquez-Ortiz, Betsy Esperanza Castro, Natasha Vanegas Gómez, Javier Escobar-Pérez
Participation of the arcRACME protein in self-activation of the arc operon located in the arginine catabolism mobile element in pandemic clone USA300.
Mem Inst Oswaldo Cruz: 2017, 112(7);499-503
[PubMed:28591311] [WorldCat.org] [DOI] (I p)