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⊟Summary[edit | edit source]
- pan ID?: SAUPAN006361000
- symbol?: arcC
- synonym:
- description?: carbamate kinase
- carbamate kinase
- carbamate kinase 2
- carbamate kinase ArcC2
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 6395426..6396367
- synteny block?: BlockID0050700
- occurrence?: in 100% of 34 strains
arcCc (arcCCONS) : constitutive arginine catabolism carbamate kinase [1]
• this version of ArcC is part of the core staphylococcal genome and is found in all strains. It is part of the arginine deiminase pathway that is actively transcribed only during aerobic growth. The "c" after "arcC" is to differentiate this version from the "a" version found in the Arginine Catabolic Metabolic Element (ACME) that sometimes accompanies the SCCmec element in MRSA, particularly the USA300 clade.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2571 (arcC)
08BA02176:
C248_2700 (arcC)
11819-97:
MS7_2637
6850:
RSAU_002475 (arcC)
71193:
ST398NM01_2682
ECT-R 2:
ECTR2_2486 (arcC)
ED133:
SAOV_2681c
ED98:
SAAV_2701 (arcC2)
HO 5096 0412:
SAEMRSA15_25370 (arcC)
JH1:
SaurJH1_2712
JH9:
SaurJH9_2656
JKD6008:
SAA6008_02691 (arcC)
JKD6159:
SAA6159_02528 (arcC)
JSNZ:
JSNZ_002621 (arcC)
LGA251:
SARLGA251_24040 (arcC)
M013:
M013TW_2613
MRSA252:
SAR2711 (arcC)
MSHR1132:
SAMSHR1132_24560
MSSA476:
SAS2518
Mu3:
SAHV_2616 (arcC)
Mu50:
SAV2632 (arcC)
MW2:
MW2553 (arcC)
RF122:
SAB2507c (arcC)
ST398:
SAPIG2682 (arcC)
T0131:
SAT0131_02898 (dapD)
TCH60:
HMPREF0772_10556 (arcC)
TW20:
SATW20_27700 (arcC)
USA300_TCH1516:
USA300HOU_2632 (arcC3)
VC40:
SAVC_12040
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL ---------MKEKIVIALGGNAIQTTEATAEAQQTAIRCAMQNLKPLFDSPARIVISHGN
N315 ---------MKEKIVIALGGNAIQTKEATAEAQQTAIRRAMQNLKPLFDSPARIVISHGN
NCTC8325 ---------MKEKIVIALGGNAIQTTEATAEAQQTAIRCAMQNLKPLFDSPARIVISHGN
Newman MFFKRSDKNMKEKIVIALGGNAIQTTEATAEAQQTAIRCAMQNLKPLFDSPARIVISHGN
USA300_FPR3757 ---------MKEKIVIALGGNAIQTTEATAEAQQTAIRCAMQNLKPLFDSPARIVISHGN
****************.************ *********************
COL GPQIGSLLIQQAKSNSDTTPAMPLDTCGAMSQGMIGYWLETEINRILTEMNSDRTVGTIV
N315 GPQIGSLLIQQAKSNSDTTPAMPLDTCGAMSQGMIGYWLETEINRILTEMNSDRTVGTIV
NCTC8325 GPQIGSLLIQQAKSNSDTTPAMPLDTCGAMSQGMIGYWLETEINRILTEMNSDRTVGTIV
Newman GPQIGSLLIQQAKSNSDTTPAMPLDTCGAMSQGMIGYWLETEINRILTEMNSDRTVGTIV
USA300_FPR3757 GPQIGSLLIQQAKSNSDTTPAMPLDTCGAMSQGMIGYWLETEINRILTEMNSDRTVGTIV
************************************************************
COL TRVEVDKDDPRFDNPTKPIGPFYTKEEVEELQKEQPDSVFKEDAGRGYRKVVASPLPQSI
N315 TRVEVDKDDPRFNNPTKPIGPFYTKEEVEELQKEQPDSVFKEDAGRGYRKVVASPLPQSI
NCTC8325 TRVEVDKDDPRFDNPTKPIGPFYTKEEVEELQKEQPDSVFKEDAGRGYRKVVASPLPQSI
Newman TRVEVDKDDPRFDNPTKPIGPFYTKEEVEELQKEQPDSVFKEDAGRGYRKVVASPLPQSI
USA300_FPR3757 TRVEVDKDDPRFDNPTKPIGPFYTKEEVEELQKEQPDSVFKEDAGRGYRKVVASPLPQSI
************:***********************************************
COL LEHQLIRTLADGKNIVIACGGGGIPVIKKENTYEGVEAVIDKDFASEKLATLIEADTLMI
N315 LEHQLIRTLADGKNIVIACGGGGIPVIKKENTYEGVEAVIDKDFASEKLATLIEADTLMI
NCTC8325 LEHQLIRTLADGKNIVIACGGGGIPVIKKENTYEGVEAVIDKDFASEKLATLIEADTLMI
Newman LEHQLIRTLADGKNIVIACGGGGIPVIKKENTYEGVEAVIDKDFASEKLATLIEADTLMI
USA300_FPR3757 LEHQLIRTLADGKNIVIACGGGGIPVIKKENTYEGVEAVIDKDFASEKLATLIEADTLMI
************************************************************
COL LTNVENVFINFNEPNQQQIDDIDVATLKKYAAQGKFVEGSMLPKIEAAIRFVESGENKKV
N315 LTNVENVFINFNEPNQQQIDDIDVATLKKYAAQGKFAEGSMLPKIEAAIRFVESGENKKV
NCTC8325 LTNVENVFINFNEPNQQQIDDIDVATLKKYAAQGKFVEGSMLPKIEAAIRFVESGENKKV
Newman LTNVENVFINFNEPNQQQIDDIDVATLKKYAAQGKFVEGSMLPKIEAAIRFVESGENKKV
USA300_FPR3757 LTNVENVFINFNEPNQQQIDDIDVATLKKYAAQGKFVEGSMLPKIEAAIRFVESGENKKV
************************************.***********************
COL IITNLEQAYEALIGNKGTHIHM
N315 IITNLEQAYEALIGNKGTHIHM
NCTC8325 IITNLEQAYEALIGNKGTHIHM
Newman IITNLEQAYEALIGNKGTHIHM
USA300_FPR3757 IITNLEQAYEALIGNKGTHIHM
**********************
- ↑ Julia Makhlin, Tzili Kofman, Ilya Borovok, Christian Kohler, Susanne Engelmann, Gerald Cohen, Yair Aharonowitz
Staphylococcus aureus ArcR controls expression of the arginine deiminase operon.
J Bacteriol: 2007, 189(16);5976-86
[PubMed:17557828] [WorldCat.org] [DOI] (P p)Zayda Lorena Corredor Rozo, Ricaurte Alejandro Márquez-Ortiz, Betsy Esperanza Castro, Natasha Vanegas Gómez, Javier Escobar-Pérez
Participation of the arcRACME protein in self-activation of the arc operon located in the arginine catabolism mobile element in pandemic clone USA300.
Mem Inst Oswaldo Cruz: 2017, 112(7);499-503
[PubMed:28591311] [WorldCat.org] [DOI] (I p)