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⊟Summary[edit | edit source]
- pan ID?: SAUPAN006134000
- symbol?: relP
- synonym:
- description?: GTP pyrophosphokinase
- GTP pyrophosphokinase
- GTP pyrophosphokinase family protein
- RelA/SpoT-like ppGpp synthetase domain protein
- GTP pyrophosphokinase ywaC
- region found in RelA / SpoT proteins family protein
- RelA/SpoT domain-containing protein
- relA-like (p)ppGpp synthetase
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 6209704..6210401
- synteny block?: BlockID0048660
- occurrence?: in 100% of 34 strains
relP : constitutive stringent response alarmone pyrophosphokinase [1]
• A crystal structure is available : 6EWZ
The stringent response alarmones pGpp, ppGpp and pppGpp are synthesized from GTP by rel, relP and relQ. RelP appears to provide a consistent level of basal alarmone production which is degraded by rel's alarmone hydrolase activity. Alarmones allosterically repress alarmone synthesis by RelP. In contrast, RelQ appears to be transcriptionally inducible and alarmones allosterically induce alarmone production resulting in positive-feedback alarmone signal amplification.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2445
08BA02176:
C248_2561
11819-97:
MS7_2512 (ywaC)
6850:
RSAU_002346
71193:
ST398NM01_2559
ECT-R 2:
ECTR2_2361
ED133:
SAOV_2550c
ED98:
SAAV_2574
HO 5096 0412:
SAEMRSA15_24050
JH1:
SaurJH1_2584
JH9:
SaurJH9_2532
JKD6008:
SAA6008_02544
JKD6159:
SAA6159_02403
JSNZ:
JSNZ_002486
LGA251:
SARLGA251_22820
M013:
M013TW_2474
MRSA252:
SAR2586
MSHR1132:
SAMSHR1132_23270
MSSA476:
SAS2394
Mu3:
SAHV_2493
Mu50:
SAV2509
MW2:
MW2427
RF122:
SAB2381c
ST398:
SAPIG2559
T0131:
SAT0131_02708
TCH60:
HMPREF0772_10688
TW20:
SATW20_26280
USA300_TCH1516:
USA300HOU_2496
VC40:
SAVC_11410
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MYVDRKPSLYLEDLRHDFKNSLSKFENGDEAFDTLLGFVELDHIYSSALKEISTKLSILD
N315 MYVDRKPSLYLEDLRHDFKNSLSKFENGDEAFDTLLGFVELDHIYSSALKEISTKLSILD
NCTC8325 MYVDRKPSLYLEDLRHDFKNSLSKFENGDEAFDTLLGFVELDHIYSSALKEISTKLSILD
Newman MYVDRKPSLYLEDLRHDFKNSLSKFENGDEAFDTLLGFVELDHIYSSALKEISTKLSILD
USA300_FPR3757 MYVDRKPSLYLEDLRHDFKNSLSKFENGDEAFDTLLGFVELDHIYSSALKEISTKLSILD
************************************************************
COL DNFNHIYKHNPIHHMERRVKEMRSLIEKLNRKGLQISAETAKEHILDIAGIRVVCNYLDD
N315 DNFNHIYKHNPIHHMERRVKEMRSLIEKLNRKGLQISAETAKEHILDIAGIRVVCNYLDD
NCTC8325 DNFNHIYKHNPIHHMERRVKEMRSLIEKLNRKGLQISAETAKEHILDIAGIRVVCNYLDD
Newman DNFNHIYKHNPIHHMERRVKEMRSLIEKLNRKGLQISAETAKEHILDIAGIRVVCNYLDD
USA300_FPR3757 DNFNHIYKHNPIHHMERRVKEMRSLIEKLNRKGLQISAETAKEHILDIAGIRVVCNYLDD
************************************************************
COL IYLIEEMLLKQEDVQLIKRKDYIQHPKENGYRSLHIVVSIPVFLAERVEVLPVEIQIRTI
N315 IYLIEEMLLKQEDVQLIKRKDYIQHPKENGYRSLHIVVSIPVFLAERVEVLPVEIQIRTI
NCTC8325 IYLIEEMLLKQEDVQLIKRKDYIQHPKENGYRSLHIVVSIPVFLAERVEVLPVEIQIRTI
Newman IYLIEEMLLKQEDVQLIKRKDYIQHPKENGYRSLHIVVSIPVFLAERVEVLPVEIQIRTI
USA300_FPR3757 IYLIEEMLLKQEDVQLIKRKDYIQHPKENGYRSLHIVVSIPVFLAERVEVLPVEIQIRTI
************************************************************
COL GMDMWASLEHKIRYKNNAETEKYRDLLKECATEITEVEDKLQQIHSEITE
N315 GMDMWASLEHKIRYKNNAETEKYRDLLKECATEITEVEDKLQQIHSEITE
NCTC8325 GMDMWASLEHKIRYKNNAETEKYRDLLKECATEITEVEDKLQQIHSEITE
Newman GMDMWASLEHKIRYKNNAETEKYRDLLKECATEITEVEDKLQQIHSEITE
USA300_FPR3757 GMDMWASLEHKIRYKNNAETEKYRDLLKECATEITEVEDKLQQIHSEITE
**************************************************
- ↑ Melek Cemre Manav, Jelena Beljantseva, Martin S Bojer, Tanel Tenson, Hanne Ingmer, Vasili Hauryliuk, Ditlev E Brodersen
Structural basis for (p)ppGpp synthesis by the Staphylococcus aureus small alarmone synthetase RelP.
J Biol Chem: 2018, 293(9);3254-3264
[PubMed:29326162] [WorldCat.org] [DOI] (I p)Ning Yang, Shujie Xie, Nga-Yeung Tang, Mei Yee Choi, Ying Wang, Rory M Watt
The Ps and Qs of alarmone synthesis in Staphylococcus aureus.
PLoS One: 2019, 14(10);e0213630
[PubMed:31613897] [WorldCat.org] [DOI] (I e)Andrea Salzer, Daniela Keinhörster, Christina Kästle, Benjamin Kästle, Christiane Wolz
Small Alarmone Synthetases RelP and RelQ of Staphylococcus aureus Are Involved in Biofilm Formation and Maintenance Under Cell Wall Stress Conditions.
Front Microbiol: 2020, 11;575882
[PubMed:33072039] [WorldCat.org] [DOI] (P e)