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⊟Summary[edit | edit source]

  • pan ID?: SAUPAN005955000
  • symbol?: sbi
  • synonym:
  • description?: immunoglobulin-binding protein sbi

      descriptions from strain specific annotations:

    • immunoglobulin-binding protein sbi
    • IgG-binding protein SBI
    • immunoglobulin G-binding protein Sbi
    • B domain protein
    • Ig-binding B domain-containing protein
  • strand?: +
  • coordinates?: 6017605..6018918
  • synteny block?: BlockID0046990
  • occurrence?: in 100% of 34 strains

sbi : staphylococcal immune subversion protein Sbi [1]

Staphylococcal immune subversion protein Sbi is a multifactorial immune evasion factor for both the innate and the adaptive immune system. Domain IV is processed and released as a soluble virulence factor (Sbi-IV) that binds complement C3d protein, sequestering it and preventing its activation. Upon interaction with domain III, the Sbi-III-Sbi-IV-C3d complex can activate the alternative complement cascade, resulting in further, futile consumption of soluble C3d protein. The two N-terminal domains of Sbi (Sbi-I and Sbi-II) remain membrane-associated and bind to the Fc regions of IgG analogous to the activity of Protein A, antagonizing opsonization and engulfment. Finally, Sbi is pro-inflammatory and modulates the host cytokine and chemokine response through EGFR signaling.

• A crystal structure is available: 6RMU

⊟Orthologs[edit | edit source]

    COL:
    SACOL2418
    N315:
    SA2206 (sbi)
    NCTC8325:
    SAOUHSC_02706
    Newman:
    NWMN_2317 (sbi)
    USA300_FPR3757:
    SAUSA300_2364 (sbi)
    JSNZ:
    JSNZ_002391 (sbi)
    04-02981:
    SA2981_2355 (sbi)
    08BA02176:
    C248_2465 (sbi)
    11819-97:
    MS7_2433 (sbi)
    6850:
    RSAU_002257 (sbi)
    71193:
    ST398NM01_2470
    ECT-R 2:
    ECTR2_2277
    ED133:
    SAOV_2466
    ED98:
    SAAV_2484
    HO 5096 0412:
    SAEMRSA15_23170 (sbi)
    JH1:
    SaurJH1_2492
    JH9:
    SaurJH9_2444
    JKD6008:
    SAA6008_02459 (sbi)
    JKD6159:
    SAA6159_02319 (sbi)
    LGA251:
    SARLGA251_22000 (sbi)
    M013:
    M013TW_2379
    MRSA252:
    SAR2508 (sbi)
    MSHR1132:
    SAMSHR1132_22470
    MSSA476:
    SAS2309
    Mu3:
    SAHV_2402 (sbi)
    Mu50:
    SAV2418 (sbi)
    MW2:
    MW2341 (sbi)
    RF122:
    SAB2298 (sbi)
    ST398:
    SAPIG2470
    T0131:
    SAT0131_02610
    TCH60:
    HMPREF0772_10769 (sbi)
    TW20:
    SATW20_25480 (sbi)
    USA300_TCH1516:
    USA300HOU_2401
    VC40:
    SAVC_10965

⊟Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757
JSNZ

⊟Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MKNKYISKLLVGAATITLATMISNGEAKASENTQQTSTKHQTTQNNYVTDQQKAFYQVLH
    N315            MKNKYISKLLVGAATITLATMISNGEAKASENTQQTSTKHQTTQNNYVTDQQKAFYQVLH
    NCTC8325        MKNKYISKLLVGAATITLATMISNGEAKASENTQQTSTKHQTTQNNYVTDQQKAFYQVLH
    Newman          MKNKYISKLLVGAATITLATMISNGEAKASENTQQTSTKHQTTQNNYVTDQQKAFYQVLH
    USA300_FPR3757  MKNKYISKLLVGAATITLATMISNGEAKASENTQQTSTKHQTTQNNYVTDQQKAFYQVLH
                    ************************************************************

    COL             LKGITEEQRNQYIKTLREHPERAQEVFSESLKDSKNPDRRVAQQNAFYNVLKNDNLTEQE
    N315            LKGITEEQRNQYIKTLREHPERAQEVFSESLKDSKNPDRRVAQQNAFYNVLKNDNLTEQE
    NCTC8325        LKGITEEQRNQYIKTLREHPERAQEVFSESLKDSKNPDRRVAQQNAFYNVLKNDNLTEQE
    Newman          LKGITEEQRNQYIKTLREHPERAQEVFSESLKDSKNPDRRVAQQNAFYNVLKNDNLTEQE
    USA300_FPR3757  LKGITEEQRNQYIKTLREHPERAQEVFSESLKDSKNPDRRVAQQNAFYNVLKNDNLTEQE
                    ************************************************************

    COL             KNNYIAQIKENPDRSQQVWVESVQSSKAKERQNIENADKAIKDFQDNKAPHDKSAAYEAN
    N315            KNNYIAQIKENPDRSQQVWVESVQSSKAKERQNIENADKAIKDFQDNKAPHDKSAAYEAN
    NCTC8325        KNNYIAQIKENPDRSQQVWVESVQSSKAKERQNIENADKAIKDFQDNKAPHDKSAAYEAN
    Newman          KNNYIAQIKENPDRSQQVWVESVQSSKAKERQNIENADKAIKDFQDNKAPHDKSAAYEAN
    USA300_FPR3757  KNNYIAQIKENPDRSQQVWVESVQSSKAKERQNIENADKAIKDFQDNKAPHDKSAAYEAN
                    ************************************************************

    COL             SKLPKDLRDKNNRFVEKVSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKA
    N315            SKLPKDLRDKNNRFVEKVSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKA
    NCTC8325        SKLPKDLRDKNNRFVEKVSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKA
    Newman          SKLPKDLRDKNNRFVEKVSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKA
    USA300_FPR3757  SKLPKDLRDKNNRFVEKVSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKA
                    ************************************************************

    COL             PMDVKEHLQKQLDALVAQKDAEKKVAPKVEAPQIQSPQIEKPKVESPKVEVPQIQSPKVE
    N315            PMDVKEHLQKQLDALVAQKDAEKKVAPKVEAPQIQSPQIEKPKAESPKVEVPQIQSPKVE
    NCTC8325        PMDVKEHLQKQLDALVAQKDAEKKVAPKVEAPQIQSPQIEKPKVESPKVEVPQIQSPKVE
    Newman          PMDVKEHLQKQLDALVAQKDAEKKVAPKVEAPQIQSPQIEKPKVESPKVEVPQIQSPKVE
    USA300_FPR3757  PMDVKEHLQKQLDALVAQKDAEKKVAPKVEAPQIQSPQIEKPKVESPKVEVPQIQSPKVE
                    *******************************************.****************

    COL             VPQSKLLGYYQSLKDSFNYGYKYLTDTYKSYKEKYDTAKYYYNTYYKYKGAIDQTVLTVL
    N315            VPQSKLLGYYQSLKDSFNYGYKYLTDTYKSYKEKYDTAKYYYNTYYKYKGAIDQTVLTVL
    NCTC8325        VPQSKLLGYYQSLKDSFNYGYKYLTDTYKSYKEKYDTAKYYYNTYYKYKGAIDQTVLTVL
    Newman          VPQSKLLGYYQSLKDSFNYGYKYLTDTYKSYKEKYDTAKYYYNTYYKYKGAIDQTVLTVL
    USA300_FPR3757  VPQSKLLGYYQSLKDSFNYGYKYLTDTYKSYKEKYDTAKYYYNTYYKYKGAIDQTVLTVL
                    ************************************************************

    COL             GSGSKSYIQPLKVDDKNGYLAKSYAQVRNYVTESINTGKVLYTFYQNPTLVKTAIKAQET
    N315            GSGSKSYIQPLKVDDKNGYLAKSYAQVRNYVTESINTGKVLYTFYQNPTLVKTAIKAQET
    NCTC8325        GSGSKSYIQPLKVDDKNGYLAKSYAQVRNYVTESINTGKVLYTFYQNPTLVKTAIKAQET
    Newman          GSGSKSYIQPLKVDDKNGYLAKSYAQVRNYVTESINTGKVLYTFYQNPTLVKTAIKAQET
    USA300_FPR3757  GSGSKSYIQPLKVDDKNGYLAKSYAQVRNYVTESINTGKVLYTFYQNPTLVKTAIKAQET
                    ************************************************************

    COL             ASSIKNTLSNLLSFWK
    N315            ASSIKNTLSNLLSFWK
    NCTC8325        ASSIKNTLSNLLSFWK
    Newman          ASSIKNTLSNLLSFWK
    USA300_FPR3757  ASSIKNTLSNLLSFWK
                    ****************

  1. ↑ Abhishek Upadhyay, Julia D Burman, Elizabeth A Clark, Elisa Leung, David E Isenman, Jean M H van den Elsen, Stefan Bagby
    Structure-function analysis of the C3 binding region of Staphylococcus aureus immune subversion protein Sbi.
    J Biol Chem: 2008, 283(32);22113-20
    [PubMed:18550524] [WorldCat.org] [DOI] (P p)    Katrin Haupt, Michael Reuter, Jean van den Elsen, Julia Burman, Steffi Hälbich, Julia Richter, Christine Skerka, Peter F Zipfel
    The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b.
    PLoS Pathog: 2008, 4(12);e1000250
    [PubMed:19112495] [WorldCat.org] [DOI] (I p)    Emma Jane Smith, Livia Visai, Steven W Kerrigan, Pietro Speziale, Timothy J Foster
    The Sbi protein is a multifunctional immune evasion factor of Staphylococcus aureus.
    Infect Immun: 2011, 79(9);3801-9
    [PubMed:21708997] [WorldCat.org] [DOI] (I p)    Emma Jane Smith, Rebecca M Corrigan, Tetje van der Sluis, Angelika Gründling, Pietro Speziale, Joan A Geoghegan, Timothy J Foster
    The immune evasion protein Sbi of Staphylococcus aureus occurs both extracellularly and anchored to the cell envelope by binding lipoteichoic acid.
    Mol Microbiol: 2012, 83(4);789-804
    [PubMed:22256861] [WorldCat.org] [DOI] (I p)    Rhys W Dunphy, Ayla A Wahid, Catherine R Back, Rebecca L Martin, Andrew G Watts, Charlotte A Dodson, Susan J Crennell, Jean M H van den Elsen
    Staphylococcal Complement Evasion Protein Sbi Stabilises C3d Dimers by Inducing an N-Terminal Helix Swap.
    Front Immunol: 2022, 13;892234
    [PubMed:35693766] [WorldCat.org] [DOI] (I e)
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