PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

FunGene: 08-OCT-2024

⊟Summary

• organism: Staphylococcus aureus JSNZ
• locus tag: JSNZ_002391
• pan locus tag^?: SAUPAN005955000
• symbol: sbi
• pan gene symbol^?: sbi
• synonym:
• product: immunoglobulin-binding protein Sbi

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: JSNZ_002391
• symbol: sbi
• product: immunoglobulin-binding protein Sbi
• replicon: chromosome
• strand: +
• coordinates: 2387257..2388567
• length: 1311
• essential: unknown other strains

⊟Accession numbers

• Gene ID:
• RefSeq:
• BioCyc:
• MicrobesOnline:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  1201
  1261
  
  ATGAAAAATAAATATATCTCGAAGTTGCTAGTTGGGGCAGCAACAATTACTTTAGCTACA
  ATGATTTCAAATGGGGAAGCAAAAGCGAGTGAAAACACGCAACAAACTTCAACTAAGCAC
  CAAACAACTCAAAACAACTACGTAACAGATCAACAAAAAGCTTTTTATCAAGTATTACAT
  CTAAAAGGTATCACAGAAGAACAACGTAACCAATACATCAAAACATTACGCGAACACCCA
  GAACGTGCACAAGAAGTATTCTCTGAATCACTTAAAGACAGCAAGAACCCAGACCGACGT
  GTTGCACAACAAAACGCTTTTTACAATGTTCTTAAAAATGATAACTTAACTGAACAAGAA
  AAAAATAATTACATTGCACAAATTAAAGAAAACCCTGATAGAAGCCAACAAGTTTGGGTA
  GAATCAGTACAATCTTCTAAAGCTAAAGAACGTCAAAATATTGAAAATGCGGATAAAGCA
  ATTAAAGATTTCCAAGATAACAAAGCACCACACGATAAATCAGCAGCATATGAAGCTAAC
  TCAAAATTACCTAAAGATTTACGCGATAAAAATAACCGCTTTGTAGAAAAAGTTTCAATT
  GAAAAAGCAATCGTTCGTCATGATGAGCGTGTGAAATCAGCAAATGATGCAATCTCAAAA
  TTACAAAAAAAAGATTCAATTGAAAACAGACGTTTAGCACAACGTGAAGTTAATAAAGCA
  CCTATGGATGTACAAAAGCACTTACAGAAACAATTAGACGCATTAGTAGCTCAAAAAGAT
  GCTGAAAAGAAAGTGGCGCCAAAAGTTGAGGTCCCTCAAATTCAATCACCACAAATTGAA
  AAACCTAAAGCAGAATCACCAAAAGTTGAAGTCCCTCAAATCCAATCACCAAAAGTTGAG
  GTTCCTCAATCTAAATTATTAGGTTACTACCAATCATTAAAAGATTCATTTAACTATGGT
  TACAAGTATTTAACAGATACTTATAAAAGCTATAAAGAAAAATATGATACAGCAAAGTAC
  TACACTGATAAATATTTTAAATATAAAGGTACAATAGATAAAACTGTACTATCAGTTTTT
  GGTAATGGATACAAATCATACATCCAACCATTAAAAGTTGAAGATCAAAAAAATTATGTA
  TCTAAATCATATGCACAAGTAAGAAACTATGTAACTGAAACTTTAAACACAGGTAAAGTA
  TTATATGCATTTTATCAAAATCCAAAAGTAGTTAAAGCTGCTATAACTACAGCTGAAACA
  GCAACATCAATCAAAAATATCTTCTCTAGTTTTACATCATTTTTTAAATAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1140
  1200
  1260
  1311
  

⊟Protein

⊟General

• locus tag: JSNZ_002391
• symbol: Sbi
• description: immunoglobulin-binding protein Sbi
• length: 436
• theoretical pI: 10.0132
• theoretical MW: 50201.2
• GRAVY: -0.957798

⊟Function

• TIGRFAM:
  Plasmodium falciparum uncharacterized protein TIGR01609 (TIGR01609; HMM-score: 5.3)
• TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
• PFAM:
  B_GA (CL0598) B; B domain (PF02216; HMM-score: 178.8)
  no clan defined Sbi-IV; C3 binding domain 4 of IgG-bind protein SBI (PF11621; HMM-score: 144.5)
  and 4 more
  DUF5392; Family of unknown function (DUF5392) (PF17370; HMM-score: 21.3)
  DUF1539; Domain of Unknown Function (DUF1539) (PF07560; HMM-score: 13.7)
  Extensin_1; Extensin-like protein (PF02095; HMM-score: 12.5)
  XhlA; Haemolysin XhlA (PF10779; HMM-score: 7.1)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 0
  • Cytoplasmic Membrane Score: 3.33
  • Cellwall Score: 3.33
  • Extracellular Score: 3.33
  • Internal Helices: 0
• DeepLocPro: Extracellular
  • Cytoplasmic Score: 0
  • Cytoplasmic Membrane Score: 0.0006
  • Cell wall & surface Score: 0.0207
  • Extracellular Score: 0.9787
• LocateP:
• SignalP: Signal peptide SP(Sec/SPI) length 29 aa
  • SP(Sec/SPI): 0.989464
  • TAT(Tat/SPI): 0.00375
  • LIPO(Sec/SPII): 0.005096
  • Cleavage Site: CS pos: 29-30. AKA-SE. Pr: 0.9454
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq:
• UniProt:

⊟Protein sequence

• MKNKYISKLLVGAATITLATMISNGEAKASENTQQTSTKHQTTQNNYVTDQQKAFYQVLHLKGITEEQRNQYIKTLREHPERAQEVFSESLKDSKNPDRRVAQQNAFYNVLKNDNLTEQEKNNYIAQIKENPDRSQQVWVESVQSSKAKERQNIENADKAIKDFQDNKAPHDKSAAYEANSKLPKDLRDKNNRFVEKVSIEKAIVRHDERVKSANDAISKLQKKDSIENRRLAQREVNKAPMDVQKHLQKQLDALVAQKDAEKKVAPKVEVPQIQSPQIEKPKAESPKVEVPQIQSPKVEVPQSKLLGYYQSLKDSFNYGYKYLTDTYKSYKEKYDTAKYYTDKYFKYKGTIDKTVLSVFGNGYKSYIQPLKVEDQKNYVSKSYAQVRNYVTETLNTGKVLYAFYQNPKVVKAAITTAETATSIKNIFSSFTSFFK

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator: SaeR (activation) regulon

  SaeR

  (TF)

  important in Virulence; regulation predicted or transferred from N315 and NCTC 8325 in Wolfgramm et al. (https://doi.org/10.1101/2025.09.03.674026)

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications

Hwan Keun Kim, Vilasack Thammavongsa, Olaf Schneewind, Dominique Missiakas
Recurrent infections and immune evasion strategies of Staphylococcus aureus.
Curr Opin Microbiol: 2012, 15(1);92-9
[PubMed:22088393] [WorldCat.org] [DOI] (I p)