⊟Summary[edit | edit source]

pan ID^?: SAUPAN005938000
symbol^?: —
synonym:
description^?: zinc ABC transporter substrate-binding protein
- zinc ABC transporter substrate-binding protein
- zinc ABC transporter substrate-binding lipoprotein AdcA
- Zn-binding lipoprotein adcA-like protein
- ABC transporter substrate-binding protein
- metal-binding lipoprotein, putative
- ABC superfamily ATP binding cassette transporter, binding protein
- ABC transporter ATP-binding protein
- Candidate zinc-binding lipoprotein ZinT
- High-affinity zinc uptake system protein znuA
- periplasmic solute binding family protein
- putative solute binding lipoprotein
- putative zinc-binding lipo protein ZinT
- ribulose-phosphate 3-epimerase
- zinc-binding lipoprotein AdcA
- Zn-binding lipoprotein adcA
strand^?: -
coordinates^?: 6004037..6005632
synteny block^?: BlockID0046820
occurrence^?: in 100% of 34 strains

znuA (adcA, mreC) : high-affinity zinc import system ion-binding protein ^[1]

⊟Orthologs[edit | edit source]

COL:

N315:

NCTC8325:

Newman:

USA300_FPR3757:

04-02981:

SA2981_2343 (zinT)

08BA02176:

C248_2453

11819-97:

MS7_2421

6850:

RSAU_002244

71193:

ST398NM01_2459

ECT-R 2:

ECTR2_2265

ED133:

SAOV_2452c

ED98:

SAAV_2471

HO 5096 0412:

SAEMRSA15_23050

JH1:

SaurJH1_2478

JH9:

SaurJH9_2430

JKD6008:

SAA6008_02447

JKD6159:

SAA6159_02307

JSNZ:

JSNZ_002375 (adcA)

LGA251:

SARLGA251_21880

M013:

M013TW_2367

MRSA252:

SAR2496

MSHR1132:

SAMSHR1132_22340

MSSA476:

SAS2297

Mu3:

SAHV_2390

Mu50:

SAV2406

MW2:

MW2328

RF122:

SAB2286c

ST398:

SAPIG2459

T0131:

SAT0131_02597

TCH60:

HMPREF0772_10781 (adcA)

TW20:

SATW20_25360

USA300_TCH1516:

USA300HOU_2386

VC40:

SAVC_10900

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.307)

COL             MKKKLGMLLLVPAVTLSLAACGNDDGKDKDGKVTIKTTVYPLQSFAEQIGGKHVKVSSIY
N315            MKKKLGMLLLVPAVTLSLAACGNDDGKDKDGKVTIKTTVYPLQSFAEQIGGKHVKVSSIY
NCTC8325        MKKKLGMLLLVPAVTLSLAACGNDDGKDKDGKVTIKTTVYPLQSFAEQIGGKHVKVSSIY
Newman          MKKKLGMLLLVPAVTLSLAACGNDDGKDKDGKVTIKTTVYPLQSFAEQIGGKHVKVSSIY
USA300_FPR3757  MKKKLGMLLLVPAVTLSLAACGNDDGKDKDGKVTIKTTVYPLQSFAEQIGGKHVKVSSIY
                ************************************************************

COL             PAGTDLHSYEPTQKDILSASKSDLFMYTGDNLDPVAKKVASTIKDKDKKLSLEDKLDKAK
N315            PAGTDLHSYEPTQKDILSASKSDLFMYTGDNLDPVAKKVASTIKDKDKKRSLEDKLDKAK
NCTC8325        PAGTDLHSYEPTQKDILSASKSDLFMYTGDNLDPVAKKVASTIKDKDKKLSLEDKLDKAK
Newman          PAGTDLHSYEPTQKDILSASKSDLFMYTGDNLDPVAKKVASTIKDKDKKLSLEDKLDKAK
USA300_FPR3757  PAGTDLHSYEPTQKDILSASKSDLFMYTGDNLDPVAKKVASTIKDKDKKLSLEDKLDKAK
                ************************************************* **********

COL             LLTDQHEHGEEHEHEGHDHEKEEHHHHHGGYDPHVWLDPKINQTFAKEIKDELVKKDPKH
N315            LLTDQHEHGEEHEHEGHDHEKEE-HHHHGGYDPHVWLDPKINQTFAKEIKDELVKKDPKH
NCTC8325        LLTDQHEHGEEHEHEGHDHEKEEHHHHHGGYDPHVWLDPKINQTFAKEIKDELVKKDPKH
Newman          LLTDQHEHGEEHEHEGHDHEKEEHHHHHGGYDPHVWLDPKINQTFAKEIKDELVKKDPKH
USA300_FPR3757  LLTDQHEHGEEHEHEGHDHEKEEHHHHHGGYDPHVWLDPKINQTFAKEIKDELVKKDPKH
                *********************** ************************************

COL             KDDYEKNYKKLNDDLKKIDNDMKQVTKDKQGNAVFISHESIGYLADCYGFVQKGIQNMNA
N315            KDDYEKNYKKLNDDLKKIDNDMKQVTKDKQGNAVFISHESIGYLADRYGFVQKGIQNMNA
NCTC8325        KDDYEKNYKKLNDDLKKIDNDMKQVTKDKQGNAVFISHESIGYLADCYGFVQKGIQNMNA
Newman          KDDYEKNYKKLNDDLKKIDNDMKQVTKDKQGNAVFISHESIGYLADCYGFVQKGIQNMNA
USA300_FPR3757  KDDYEKNYKKLNDDLKKIDNDMKQVTKDKQGNAVFISHESIGYLADCYGFVQKGIQNMNA
                ********************************************** *************

COL             EDPSQKELTKIVKEIRDSNAKYILYEDNVANKVTETIRKETDAKPLKFYNMESLNKEQQK
N315            EDPSQKELTKIVKEIRDSNAKYILYEDNVANKVTETIRKETDAKPLKFYNMESLNKEQQK
NCTC8325        EDPSQKELTKIVKEIRDSNAKYILYEDNVANKVTETIRKETDAKPLKFYNMESLNKEQQK
Newman          EDPSQKELTKIVKEIRDSNAKYILYEDNVANKVTETIRKETDAKPLKFYNMESLNKEQQK
USA300_FPR3757  EDPSQKELTKIVKEIRDSNAKYILYEDNVANKVTETIRKETDAKPLKFYNMESLNKEQQK
                ************************************************************

COL             KDNITYQSLMKSNIENIGKALDSGVKVKDDKAESKHDKAISDGYFKDEQVKDRELSDYAG
N315            KDNITYQSLMKSNIENIGKALDSGVKVKDDKAESKHDKAISDGYFKDEQVKDRELSDYAG
NCTC8325        KDNITYQSLMKSNIENIGKALDSGVKVKDDKAESKHDKAISDGYFKDEQVKDRELSDYAG
Newman          KDNITYQSLMKSNIENIGKALDSGVKVKDDKAESKHDKAISDGYFKDEQVKDRELSDYAG
USA300_FPR3757  KDNITYQSLMKSNIENIGKALDSGVKVKDDKAESKHDKAISDGYFKDEQVKDRELSDYAG
                ************************************************************

COL             EWQSVYPYLKDGTLDEVMEHKAENDPKKSAKDLKAYYDKGYKTDITNIDIKGNEITFTKD
N315            EWQSVYPYLKDGTLDEVMEHKAENDPKKSAKDLKAYYDKGYKTDITNIDIKGNEITFTKD
NCTC8325        EWQSVYPYLKDGTLDEVMEHKAENDPKKSAKDLKAYYDKGYKTDITNIDIKGNEITFTKD
Newman          EWQSVYPYLKDGTLDEVMEHKAENDPKKSAKDLKAYYDKGYKTDITNIDIKGNEITFTKD
USA300_FPR3757  EWQSVYPYLKDGTLDEVMEHKAENDPKKSAKDLKAYYDKGYKTDITNIDIKGNEITFTKD
                ************************************************************

COL             GKKHTGKYEYNGKKTLKYPKGNRGVRFMFKLVDGNDKDLPKFIQFSDHNIAPKKAEHFHI
N315            GKKHTGKYEYNGKKTLKYPKGNRGVRFMFKLVDGNDKDLPKFIQFSDHNIAPKKAEHFHI
NCTC8325        GKKHTGKYEYNGKKTLKYPKGNRGVRFMFKLVDGNDKDLPKFIQFSDHNIAPKKAEHFHI
Newman          GKKHTGKYEYNGKKTLKYPKGNRGVRFMFKLVDGNDKDLPKFIQFSDHHIAPKKAEHFHI
USA300_FPR3757  GKKHTGKYEYNGKKTLKYPKGNRGVRFMFKLVDGNDKDLPKFIQFSDHNIAPKKAEHFHI
                ************************************************:***********

COL             FMGNDNDALLKEMDNWPTYYPSKLNKDQIKEEMLAH---------------
N315            FMGNDNDALLKEMDNWPTYYPSKLNKDQIKEEMLAH---------------
NCTC8325        FMGNDNDALLKEMDNWPTYYPSKLNKDQIKEEMLAH---------------
Newman          FMGNDNDALLKRMDYWPTYYPSKLNKDPIKEEMLAHYFNRFAHSTQLLIAE
USA300_FPR3757  FMGNDNDALLKEMDNWPTYYPSKLNKDQIKEEMLAH---------------
                ***********.** ************ ********

↑ Natália Salazar, Bruno Bernardi Yamamoto, Matilde Costa Lima de Souza, Ludmila Bezerra da Silva, Ana Paula Mattos Arêas, Angela Silva Barbosa
The C-Terminal Domain of Staphylococcus aureus Zinc Transport Protein AdcA Binds Plasminogen and Factor H In Vitro.
Pathogens: 2022, 11(2);
[PubMed:35215183] [WorldCat.org] [DOI] (P e)Kyle P Grim, Brian San Francisco, Jana N Radin, Erin B Brazel, Jessica L Kelliher, Paola K Párraga Solórzano, Philip C Kim, Christopher A McDevitt, Thomas E Kehl-Fie
The Metallophore Staphylopine Enables Staphylococcus aureus To Compete with the Host for Zinc and Overcome Nutritional Immunity.
mBio: 2017, 8(5);
[PubMed:29089427] [WorldCat.org] [DOI] (I e)Jodi A Lindsay, Simon J Foster
zur: a Zn(2+)-responsive regulatory element of Staphylococcus aureus.
Microbiology (Reading): 2001, 147(Pt 5);1259-1266
[PubMed:11320129] [WorldCat.org] [DOI] (P p)

[1] Natália Salazar, Bruno Bernardi Yamamoto, Matilde Costa Lima de Souza, Ludmila Bezerra da Silva, Ana Paula Mattos Arêas, Angela Silva Barbosa
The C-Terminal Domain of Staphylococcus aureus Zinc Transport Protein AdcA Binds Plasminogen and Factor H In Vitro.
Pathogens: 2022, 11(2);
[PubMed:35215183] [WorldCat.org] [DOI] (P e)Kyle P Grim, Brian San Francisco, Jana N Radin, Erin B Brazel, Jessica L Kelliher, Paola K Párraga Solórzano, Philip C Kim, Christopher A McDevitt, Thomas E Kehl-Fie
The Metallophore Staphylopine Enables Staphylococcus aureus To Compete with the Host for Zinc and Overcome Nutritional Immunity.
mBio: 2017, 8(5);
[PubMed:29089427] [WorldCat.org] [DOI] (I e)Jodi A Lindsay, Simon J Foster
zur: a Zn(2+)-responsive regulatory element of Staphylococcus aureus.
Microbiology (Reading): 2001, 147(Pt 5);1259-1266
[PubMed:11320129] [WorldCat.org] [DOI] (P p)

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]