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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005926000
- symbol?: narJ
- synonym:
- description?: nitrate reductase molybdenum cofactor assembly chaperone
- nitrate reductase molybdenum cofactor assembly chaperone
- respiratory nitrate reductase subunit delta
- respiratory nitrate reductase, delta subunit
- respiratory nitrate reductase, subunit delta
- respiratory nitrate reductase delta chain
- nitrate reductase delta subunit
- nitrate reductase subunit delta
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 5989764..5990291
- synteny block?: BlockID0046700
- occurrence?: in 100% of 34 strains
narJ : respiratory nitrate reductase molybdenum cofactor assembly chaperone delta [1]
Respiratory nitrate reductase (NAR) allows staphylococci to continue electron transport under anaerobic conditions with nitrate as a terminal electron acceptor. The delta subunit acts as a chaperone maintaining the apo alpha subunit in a conformation able to receive its molybdopterin cofactor. It may serve a secondary role as a structural protein that maintains the unstable alpha-beta protein complex in the proper configuration for catalytic activity. Intriguingly, respiratory nitrogen reductase stimulates agr production, increases virulence and decreases the host immune response but only in USA300 staphylococci.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2332
08BA02176:
C248_2442 (narJ)
11819-97:
MS7_2410 (narJ)
6850:
RSAU_002233 (narJ)
71193:
ST398NM01_2448
ECT-R 2:
ECTR2_2254 (narJ)
ED133:
SAOV_2440c
ED98:
SAAV_2460 (narJ)
HO 5096 0412:
SAEMRSA15_22940 (narJ)
JH1:
SaurJH1_2467
JH9:
SaurJH9_2419
JKD6008:
SAA6008_02436 (narJ)
JKD6159:
SAA6159_02296 (narJ)
JSNZ:
JSNZ_002363 (narJ)
LGA251:
SARLGA251_21770 (narJ)
M013:
M013TW_2356
MRSA252:
SAR2484 (narJ)
MSHR1132:
SAMSHR1132_22230
MSSA476:
SAS2286
Mu3:
SAHV_2379
Mu50:
SAV2395
MW2:
MW2317
RF122:
SAB2274c (narJ)
ST398:
SAPIG2448 (narJ)
T0131:
SAT0131_02586
TCH60:
HMPREF0772_10792 (narJ)
TW20:
SATW20_25250 (narJ)
USA300_TCH1516:
USA300HOU_2377 (narJ)
VC40:
SAVC_10845
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MEGFSVINFDNFKKYQESFGYMAQQLCFPEKLTFHPKTFEETISKDHPAYEDLVAFRNVM
N315 -----MINFDNFKKYQESFGYMAQQLCFPEKLTFHPKTFEETISKDHPAYEDLVAFRNVM
NCTC8325 MEGFSVINFDNFKKYQESFGYMAQQLCFPEKLTFHPKTFEETISKDHPAYEDLVAFRNVM
Newman MEGFSVINFDNFKKYQESFGYMAQQLCFPEKLTFHPKTFEETISKDHPAYEDLVAFRNVM
USA300_FPR3757 MEGFSVINFDNFKKYQESFGYMAQQLCFPEKLTFHPKTFEETISKDHPAYEDLVAFRNVM
:******************************************************
COL MTFSLSEIKAIYTDTFDFTKKAPLYMTYNKFDTQKERGQMLAKLKVLYEMFGLEMVDNEL
N315 MTFSLSEIKAIYTDTFDFTKKAPLYMTYNKFDTQKERGQMLAKLKVLYEMFGLEMVDNEL
NCTC8325 MTFSLSEIKAIYTDTFDFTKKAPLYMTYNKFDTQKERGQMLAKLKVLYEMFGLEMVDNEL
Newman MTFSLSEIKAIYTDTFDFTKKAPLYMTYNKFDTQKERGQMLAKLKVLYEMFGLEMVDNEL
USA300_FPR3757 MTFSLSEIKAIYTDTFDFTKKAPLYMTYNKFDTQKERGQMLAKLKVLYEMFGLEMVDNEL
************************************************************
COL SDYLPLMLQFLQVAEWRNDPRAEENIQLIIMIIEDGTYVMANALGEDNNPYAYVIQALRK
N315 SDYLPLMLQFLQVAEWRNDPRAEENIQLIIMIIEDGTYVMANALGEDNNPYAYVIQALRK
NCTC8325 SDYLPLMLQFLQVAEWRNDPRAEENIQLIIMIIEDGTYVMANALGEDNNPYAYVIQALRK
Newman SDYLPLMLQFLQVAEWRNDPRAEENIQLIIMIIEDGTYVMANALGEDNNPYAYVIQALRK
USA300_FPR3757 SDYLPLMLQFLQVAEWRNDPRAEENIQLIIMIIEDGTYVMANALGEDNNPYAYVIQALRK
************************************************************
COL TLKLCLTSPKGVKHHA
N315 TLKLCLTSPKGVKHHA
NCTC8325 TLKLCLTSPKGVKHHA
Newman TLKLCLTSPKGVKHHA
USA300_FPR3757 TLKLCLTSPKGVKHHA
****************
- ↑ Yujie Li, Ting Pan, Ruobing Cao, Wei Li, Zhien He, Baolin Sun
Nitrate Reductase NarGHJI Modulates Virulence via Regulation of agr Expression in Methicillin-Resistant Staphylococcus aureus Strain USA300 LAC.
Microbiol Spectr: 2023, 11(3);e0359622
[PubMed:37199609] [WorldCat.org] [DOI] (I p)