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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005925000
- symbol?: narI
- synonym:
- description?: nitrate reductase subunit gamma
- nitrate reductase subunit gamma
- respiratory nitrate reductase subunit gamma
- respiratory nitrate reductase, gamma subunit
- nitrate reductase gamma chain
- nitrate reductase gamma subunit
- putative nitrate reductase gamma chain
- Respiratory nitrate reductase gamma chain
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 5989094..5989771
- synteny block?: BlockID0046690
- occurrence?: in 100% of 34 strains
narI : respiratory nitrate reductase subunit gamma [1]
Respiratory nitrate reductase (NAR) allows staphylococci to continue electron transport under anaerobic conditions with nitrate as a terminal electron acceptor. The gamma subunit acts as a cytochrome b-like protein, transferring electrons from reduced menaquinones, NADH or NADPH to the beta subunit. Intriguingly, respiratory nitrogen reductase stimulates agr production, increases virulence and decreases the host immune response but only in USA300 staphylococci.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2331 (narI)
08BA02176:
C248_2441 (narI)
11819-97:
MS7_2409 (narI)
6850:
RSAU_002232 (narI)
71193:
ST398NM01_2447
ECT-R 2:
ECTR2_2253 (narI)
ED133:
SAOV_2439c
ED98:
SAAV_2459 (narI)
HO 5096 0412:
SAEMRSA15_22930 (narI)
JH1:
SaurJH1_2466
JH9:
SaurJH9_2418
JKD6008:
SAA6008_02435 (narI)
JKD6159:
SAA6159_02295 (narI)
JSNZ:
JSNZ_002362 (narI)
LGA251:
SARLGA251_21760 (narI)
M013:
M013TW_2355
MRSA252:
SAR2483 (narI)
MSHR1132:
SAMSHR1132_22220
MSSA476:
SAS2285
Mu3:
SAHV_2378 (narI)
Mu50:
SAV2394 (narI)
MW2:
MW2316 (narI)
RF122:
SAB2273c (narI)
ST398:
SAPIG2447 (narI)
T0131:
SAT0131_02585
TCH60:
HMPREF0772_10793 (narI)
TW20:
SATW20_25240 (narI)
USA300_TCH1516:
USA300HOU_2376 (narI)
VC40:
SAVC_10840
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MLNQFLWVIFPYLCLVVFVAGHIARYRYDKFSWTAKSSELIERKRLMWGSLLFHLGIIPV
N315 MLNQFLWVIFPYLCLVVFVAGHIARYRYDKFSWTAKSSELIERKRLMWGSLLFHLGIIPV
NCTC8325 MLNQFLWVIFPYLCLVVFVAGHIARYRYDKFSWTAKSSELIERKRLMWGSLLFHLGIIPV
Newman MLNQFLWVIFPYLCLVVFVAGHIARYRYDKFSWTAKSSELIERKRLMWGSLLFHLGIIPV
USA300_FPR3757 MLNQFLWVIFPYLCLVVFVAGHIARYRYDKFSWTAKSSELIERKRLMWGSLLFHLGIIPV
************************************************************
COL FFGHVVGLLIPKPWMDAVGVSEHLYHIGAVYIGSIFGIITLIGMFLLTARRVTTKSIRRL
N315 FFGHVVGLLIPKSWMDAVGVSEHLYHIGAVYIGSIFGIITLIGMFLLTARRVTTKSIRRL
NCTC8325 FFGHVVGLLIPKPWMDAVGVSEHLYHIGAVYIGSIFGIITLIGMFLLTARRVTTKSIRRL
Newman FFGHVVGLLIPKPWMDAVGVSEHLYHIGAVYIGSIFGIITLIGMFLLTARRVTTKSIRRL
USA300_FPR3757 FFGHVVGLLIPKPWMDAVGVSEHLYHIGAVYIGSIFGIITLIGMFLLTARRVTTKSIRRL
************.***********************************************
COL SSASDIFVNFLLLLIVFMGCYATLVTNIQHPDFNYRTSLSIWFRQLFMLKPDASLMSGVP
N315 SSASDIFVNFLLLLIVFMGCYATLVTNIQHPDFNYRTSLSIWFRQLFMLKPDASLMSGVP
NCTC8325 SSASDIFVNFLLLLIVFMGCYATLVTNIQHPDFNYRTSLSIWFRQLFMLKPDASLMSGVP
Newman SSASDIFVNFLLLLIVFMGCYATLVTNIQHPDFNYRTSLSIWFRQLFMLKPDASLMSGVP
USA300_FPR3757 SSASDIFVNFLLLLIVFMGCYATLVTNIQHPDFNYRTSLSIWFRQLFMLKPDASLMSGVP
************************************************************
COL IAFKMHILLGFTIMACWPFTRLVHVWSVPLTYINRRYIIYRKNKV
N315 IAFKMHILLGFTIMACWPFTRLVHVWSVPLTYINRRYIIYRKNKV
NCTC8325 IAFKMHILLGFTIMACWPFTRLVHVWSVPLTYINRRYIIYRKNKV
Newman IAFKMHILLGFTIMACWPFTRLVHVWSVPLTYINRRYIIYRKNKV
USA300_FPR3757 IAFKMHILLGFTIMACWPFTRLVHVWSVPLTYINRRYIIYRKNKV
*********************************************
- ↑ Yujie Li, Ting Pan, Ruobing Cao, Wei Li, Zhien He, Baolin Sun
Nitrate Reductase NarGHJI Modulates Virulence via Regulation of agr Expression in Methicillin-Resistant Staphylococcus aureus Strain USA300 LAC.
Microbiol Spectr: 2023, 11(3);e0359622
[PubMed:37199609] [WorldCat.org] [DOI] (I p)