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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005744000
- symbol?: bioY
- synonym:
- description?: biotin transporter BioY
- biotin transporter BioY
- BioY family protein
- biotin biosynthesis BioY family protein
- BioY family biotin uptake protein, putative
- biotin biosynthesis protein
- Bioy
- BioY protein
- ECF transporter substrate-specific protein BioY
- Substrate-specific component BioY of biotin ECF transporter
- transmembranal protein BioY
- transmembrane protein BioY
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 5842365..5842939
- synteny block?: BlockID0044900
- occurrence?: in 100% of 34 strains
bioY : energy-coupling factor transporter biotin-binding subunit BioY [1]
Staphylococci employ a variant of ABC transporters, the type 2 energy-coupling factor (ECF) transporters, to acquire trace nutrients. Three core subunits comprise a single, universal ATPase/transmembrane channel (EcfA-EcfA'-EcfT) while individual membrane-embedded substrate-binding subunits (EcfS) provide substrate specificity. BioY is an EcfS protein specific for the substrate biotin.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2220 (bioY)
08BA02176:
C248_2320
11819-97:
MS7_2301 (bioY)
6850:
RSAU_002116
71193:
ST398NM01_2333
ECT-R 2:
ECTR2_2143
ED133:
SAOV_2321c
ED98:
SAAV_2345
HO 5096 0412:
SAEMRSA15_21800
JH1:
SaurJH1_2349
JH9:
SaurJH9_2307
JKD6008:
SAA6008_02319
JKD6159:
SAA6159_02187
JSNZ:
JSNZ_002249
LGA251:
SARLGA251_20660
M013:
M013TW_2240
MRSA252:
SAR2366
MSHR1132:
SAMSHR1132_21080
MSSA476:
SAS2172
Mu3:
SAHV_2266
Mu50:
SAV2282
MW2:
MW2200
RF122:
SAB2154c
ST398:
SAPIG2333
T0131:
SAT0131_02460 (isdE)
TCH60:
HMPREF0772_10916
TW20:
SATW20_24140
USA300_TCH1516:
USA300HOU_2264
VC40:
SAVC_10275
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MTTKQLVYTALMTAIIAILGLVPVIPLPFSSVPIVLQNIGIFLAGVILGRKYGTLSVIVF
N315 MTTKQLVYTALMTAIIAILGMVPVIPLPFSSVPIVLQNIGIFLAGVILGRKYGTLSVIVF
NCTC8325 MTTKQLVYTALMTAIIAILGLVPVIPLPFSSVPIVLQNIGIFLAGAILGRKYGTLSVIVF
Newman MTTKQLVYTALMTAIIAILGLVPVIPLPFSSVPIVLQNIGIFLAGVILGRKYGTLSVIVF
USA300_FPR3757 MTTKQLVYTALMTAIIAILGLVPVIPLPFSSVPIVLQNIGIFLAGVILGRKYGTLSVIVF
********************:************************.**************
COL LLLVVAGLPLLSGGRGGIGVFAGPSAGFLLLYPVVAFMIGAIRDRFINEINFWILFVGIL
N315 LLLVVAGLPLLSGGRGGIGVFAGPSAGFLLLYPVVAFMIGAIRDRFINEINFWILFVGIL
NCTC8325 LLLVVAGLPLLSGGRGGIGVFAGPSAGFLLLYPVVAFMIGAIRDRFINEINFWILFVGIL
Newman LLLVVAGLPLLSGGRGGIGVFAGPSAGFLLLYPVVAFMIGAIRDRFINEINFWILFVGIL
USA300_FPR3757 LLLVVAGLPLLSGGRGGIGVFAGPSAGFLLLYPVVAFMIGAIRDRFINEINFWILFVGIL
************************************************************
COL VFGVIALDVIGTLIMGMIINIPFTKAISISLAYLPGDILKAIVASLIGTALLNHSQFRQI
N315 VFGVIALDVIGTLIMGMIINIPFTKAISISLAYLPGDILKAIVASLIGTALLNHSQFRQI
NCTC8325 VFGVIALDVIGTLIMGMIINIPFTKAISISLAYLPGDILKAIVASLIGTALLNHSQFRQI
Newman VFGVIALDVIGTLIMGMIINIPFTKAISISLAYLPGDILKAIVASLIGTALLNHSQFRQI
USA300_FPR3757 VFGVIALDVIGTLIMGMIINIPFTKAISISLAYLPGDILKAIVASLIGTALLNHSQFRQI
************************************************************
COL MGIK
N315 MGLK
NCTC8325 MGIK
Newman MGIK
USA300_FPR3757 MGIK
**:*
- ↑ Jiulia Satiaputra, Bart A Eijkelkamp, Christopher A McDevitt, Keith E Shearwin, Grant W Booker, Steven W Polyak
Biotin-mediated growth and gene expression in Staphylococcus aureus is highly responsive to environmental biotin.
Appl Microbiol Biotechnol: 2018, 102(8);3793-3803
[PubMed:29508030] [WorldCat.org] [DOI] (I p)Nina Schleimer, Ursula Kaspar, Mike Drescher, Jochen Seggewiß, Christof von Eiff, Richard A Proctor, Georg Peters, André Kriegeskorte, Karsten Becker
The Energy-Coupling Factor Transporter Module EcfAA'T, a Novel Candidate for the Genetic Basis of Fatty Acid-Auxotrophic Small-Colony Variants of Staphylococcus aureus.
Front Microbiol: 2018, 9;1863
[PubMed:30154773] [WorldCat.org] [DOI] (P e)