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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005730000
- symbol?: mobA
- synonym:
- description?: molybdopterin-guanine dinucleotide biosynthesis protein MobA
- molybdopterin-guanine dinucleotide biosynthesis protein MobA
- molybdenum cofactor guanylyltransferase
- molybdenum cofactor guanylyltransferase MobA
- molybdopterin-guanine dinucleotide biosynthesis protein A
- putative molybdopterin-guanine dinucleotidebiosynthesis protein A
- molybdopterin-guanine dinucleotide biosynthesis mobA
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 5831882..5832481
- synteny block?: BlockID0044760
- occurrence?: in 100% of 34 strains
mobA : molybdopterin-guanine dinucleotide biosynthesis guanylyltransferase [1]
MobAB functionalize molybdopterin cofactor (MoCo) with a GMP resulting in molybdopterin guanine dinucleotide cofactor (MGD). A second equivalent is frequently coordinated to the same molybdenum ion resulting in bis-molybdopterin-guanine dinucleotide cofactor (bis-MGD). MobA acts as the guanylyltransferase, catalyzing the transfer of GMP from GTP. The role of MobB is less clear with potential functions as a MobA stabilizing protein, a GTPase that provides the GMP for MobA to transfer to the MoCo substrate, or as a stabilization element to encourage formation of bis-MGD.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2207 (mobA)
08BA02176:
C248_2307 (mobA)
11819-97:
MS7_2288 (mobA)
6850:
RSAU_002103 (mobA)
71193:
ST398NM01_2320
ECT-R 2:
ECTR2_2130
ED133:
SAOV_2308c
ED98:
SAAV_2332 (mobA)
HO 5096 0412:
SAEMRSA15_21670 (mobA)
JH1:
SaurJH1_2336 (mobA)
JH9:
SaurJH9_2294 (mobA)
JKD6008:
SAA6008_02306 (mobA)
JKD6159:
SAA6159_02174 (mobA)
JSNZ:
JSNZ_002236 (mobA)
LGA251:
SARLGA251_20530 (mobA)
M013:
M013TW_2227
MRSA252:
SAR2353 (mobA)
MSHR1132:
SAMSHR1132_20940
MSSA476:
SAS2159 (mobA)
Mu3:
SAHV_2253 (mobA)
Mu50:
SAV2269 (mobA)
MW2:
MW2187 (mobA)
RF122:
SAB2141c (mobA)
ST398:
SAPIG2320
T0131:
SAT0131_02446
TCH60:
HMPREF0772_10929 (mobA)
TW20:
SATW20_24010 (mobA)
USA300_TCH1516:
USA300HOU_2251 (mobA)
VC40:
SAVC_10210 (mobA)
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKAIILAGGHSVRFGKPKAFAEVNGETFYSRVIKTLESTNMFNEIIISTNAQLATQFKYP
N315 MKAIILAGGHSVRFGKPKAFAEVNGETFYSRVIKTLESTNMFNEIIISTNAQLATQFKYP
NCTC8325 MKAIILAGGHSVRFGKPKAFAEVNGETFYSRVIKTLESTNMFNEIIISTNAQLATQFKYP
Newman MKAIILAGGHSVRFGKPKAFAEVNGETFYSRVIKTLESTNMFNEIIISTNAQLATQFKYP
USA300_FPR3757 MKAIILAGGHSVRFGKPKAFAEVNGETFYSRVIKTLESTNMFNEIIISTNAQLATQFKYP
************************************************************
COL NVVIDDENHNDKGPLAGIYTIMKQHPEEELFFVVSVDTPMITGKAVSTLYQFLVSHLIEN
N315 NVVIDDENHNDKGPLAGIYTIMKQHPEEELFFVVSVDTPMITGKAVSTLYQFLVSHLIEN
NCTC8325 NVVIDDENHNDKGPLAGIYTIMKQHPEEELFFVVSVDTPMITGKAVSTLYQFLVSHLIEN
Newman NVVIDDENHNDKGPLAGIYTIMKQHPEEELFFVVSVDTPMITGKAVSTLYQFLVSHLIEN
USA300_FPR3757 NVVIDDENHNDKGPLAGIYTIMKQHPEEELFFVVSVDTPMITGKAVSTLYQFLVSHLIEN
************************************************************
COL HLDVAAFKEDGRFIPTIAFYSPNALGAITKALHSDNYSFKNVYHELSTDYLDVRDVDAPS
N315 HLDVAAFKEDGRFIPTIAFYSPNALGAITKALHSDNYSFKNIYHELSTDYLDVRDVDAPS
NCTC8325 HLDVAAFKEDGRFIPTIAFYSPNALGAITKALHSDNYSFKNVYHELSTDYLDVRDVDAPS
Newman HLDVAAFKEDGRFIPTIAFYSPNALGAITKALHSDNYSFKNVYHELSTDYLDVRDVDAPS
USA300_FPR3757 HLDVAAFKEDGRFIPTIAFYSPNALGAITKALHSDNYSFKNVYHELSTDYLDVRDVDAPS
*****************************************:******************
COL YWYKNINYQHDLDALIQKL
N315 YWYKNINYQHDLDALIQKL
NCTC8325 YWYKNINYQHDLDALIQKL
Newman YWYKNINYQHDLDALIQKL
USA300_FPR3757 YWYKNINYQHDLDALIQKL
*******************
- ↑ Na Zhao, Yanan Wang, Junlan Liu, Ziyu Yang, Ying Jian, Hua Wang, Mahmoud Ahmed, Min Li, Taeok Bae, Qian Liu
Molybdopterin biosynthesis pathway contributes to the regulation of SaeRS two-component system by ClpP in Staphylococcus aureus.
Virulence: 2022, 13(1);727-739
[PubMed:35481455] [WorldCat.org] [DOI] (I p)