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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005506000
- symbol?: glmM
- synonym:
- description?: phosphoglucosamine mutase
- phosphoglucosamine mutase
- Phosphoglucosamine mutase / FemD, factor involved in methicillin resistance
- phosphoglucosamine mutase FemD, methicillin resistance
- phosphoglucosamine mutase GlmM
- putative phosphoglucosamine mutase
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 5670777..5672132
- synteny block?: BlockID0042880
- occurrence?: in 100% of 34 strains
glmM (femD) : phosphoglucosamine mutase [1]
• A crystal structure is available : 6GYZ
One of the early rate-limiting steps in peptidoglycan synthesis is the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate by phosphoglucosamine mutase (GlmM). Levels of this enzyme are regulated transcriptionally and its enzymatic activity can be further calibrated by phosphorylation through Stk1 serine/threonine kinase. GlmM is also involved in the cell turgor regulatory system through the dacA-cdaR-glmM operon. GlmM binds and inhibits DacA, thus reducing cyclic-di-AMP-mediated turgor pressure until the cell wall can accommodate the increased intracellular pressure through increased glucose-1-phosphate conversion and, by extension, peptidoglycan synthesis.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2100 (glmM)
08BA02176:
C248_2189
11819-97:
MS7_2176 (glmM)
6850:
RSAU_001997 (glmM)
71193:
ST398NM01_2216
ECT-R 2:
ECTR2_2014 (glmM)
ED133:
SAOV_2200c
ED98:
SAAV_2215 (glmM)
HO 5096 0412:
SAEMRSA15_20670
JH1:
SaurJH1_2231 (glmM)
JH9:
SaurJH9_2193 (glmM)
JKD6008:
SAA6008_02198 (glmM)
JKD6159:
SAA6159_02070 (glmM)
JSNZ:
JSNZ_002121 (glmM)
LGA251:
SARLGA251_19570
M013:
M013TW_2119
MRSA252:
SAR2252 (glmM)
MSHR1132:
SAMSHR1132_19930
MSSA476:
SAS2063 (glmM)
Mu3:
SAHV_2145 (glmM)
Mu50:
SAV2161 (glmM)
MW2:
MW2088 (glmM)
RF122:
SAB2041c (glmM)
ST398:
SAPIG2216 (glmM)
T0131:
SAT0131_02326
TCH60:
HMPREF0772_11031 (glmM)
TW20:
SATW20_22960
USA300_TCH1516:
USA300HOU_2151 (glmM)
VC40:
SAVC_09670 (glmM)
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MGKYFGTDGVRGVANQELTPELAFKLGRYGGYVLAHNKGEKHPRVLVGRDTRVSGEMLES
N315 MGKYFGTDGVRGVANQELTPELAFKLGRYGGYVLAHNKGEKHPRVLVGRDTRVSGEMLES
NCTC8325 MGKYFGTDGVRGVANQELTPELAFKLGRYGGYVLAHNKGEKHPRVLVGRDTRVSGEMLES
Newman MGKYFGTDGVRGVANQELTPELAFKLGRYGGYVLAHNKGEKHPRVLVGRDTRVSGEMLES
USA300_FPR3757 MGKYFGTDGVRGVANQELTPELAFKLGRYGGYVLAHNKGEKHPRVLVGRDTRVSGEMLES
************************************************************
COL ALIAGLISIGAEVMRLGIISTPGVAYLTRDMGAELGVMISASHNPVADNGIKFFGSDGFK
N315 ALIAGLISIGAEVMRLGIISTPGVAYLTRDMGAELGVMISASHNPVADNGIKFFGSDGFK
NCTC8325 ALIAGLISIGAEVMRLGIISTPGVAYLTRDMGAELGVMISASHNPVADNGIKFFGSDGFK
Newman ALIAGLISIGAEVMRLGIISTPGVAYLTRDMGAELGVMISASHNPVADNGIKFFGSDGFK
USA300_FPR3757 ALIAGLISIGAEVMRLGIISTPGVAYLTRDMGAELGVMISASHNPVADNGIKFFGSDGFK
************************************************************
COL LSDEQENEIEALLDQENPELPRPVGNDIVHYSDYFEGAQKYLSYLKSTVDVNFEGLKIAL
N315 LSDEQENEIEALLDQENPELPRPVGNDIVHYSDYFEGAQKYLSYLKSTVDVNFEGLKIVL
NCTC8325 LSDEQENEIEALLDQENPELPRPVGNDIVHYSDYFEGAQKYLSYLKSTVDVNFEGLKIAL
Newman LSDEQENEIEALLDQENPELPRPVGNDIVHYSDYFEGAQKYLSYLKSTVDVNFEGLKIAL
USA300_FPR3757 LSDEQENEIEALLDQENPELPRPVGNDIVHYSDYFEGAQKYLSYLKSTVDVNFEGLKIAL
**********************************************************.*
COL DGANGSTSSLAPFLFGDLEADTETIGCSPDGYNINEKCGSTHPEKLAEKVVETESDFGLA
N315 DGANGSTSSLAPFLFGDLEADTETIGCSPDGYNINEKCGSTHPEKLAEKVVETESDFGLA
NCTC8325 DGANGSTSSLAPFLFGDLEADTETIGCSPDGYNINEKCGSTHPEKLAEKVVETESDFGLA
Newman DGANGSTSSLAPFLFGDLEADTETIGCSPDGYNINEKCGSTHPEKLAEKVVETESDFGLA
USA300_FPR3757 DGANGSTSSLAPFLFGDLEADTETIGCSPDGYNINEKCGSTHPEKLAEKVVETESDFGLA
************************************************************
COL FDGDGDRIIAVDENGQIVDGDQIMFIIGQEMHKNQELNNDMIVSTVMSNLGFYKALEQEG
N315 FDGDGDRIIAVDENGQIVDGDQIMFIIGQEMHKNQELNNDMIVSTVMSNLGFYKALEQEG
NCTC8325 FDGDGDRIIAVDENGQIVDGDQIMFIIGQEMHKNQELNNDMIVSTVMSNLGFYKALEQEG
Newman FDGDGDRIIAVDENGQIVDGDQIMFIIGQEMHKNQELNNDMIVSTVMSNLGFYKALEQEG
USA300_FPR3757 FDGDGDRIIAVDENGQIVDGDQIMFIIGQEMHKNQELNNDMIVSTVMSNLGFYKALEQEG
************************************************************
COL IKSNKTKVGDRYVVEEMRRGNYNLGGEQSGHIVMMDYNTTGDGLLTGIQLASVIKMTGKS
N315 IKSNKTKVGDRYVVEEMRRGNYNLGGEQSGHIVMMDYNTTGDGLLTGIQLASVIKMTGKS
NCTC8325 IKSNKTKVGDRYVVEEMRRGNYNLGGEQSGHIVMMDYNTTGDGLLTGIQLASVIKMTGKS
Newman IKSNKTKVGDRYVVEEMRRGNYNLGGEQSGHIVMMDYNTTGDGLLTGIQLASVIKMTGKS
USA300_FPR3757 IKSNKTKVGDRYVVEEMRRGNYNLGGEQSGHIVMMDYNTTGDGLLTGIQLASVIKMTGKS
************************************************************
COL LSELAGQMKKYPQSLINVRVTDKYRVEENVDVKEVMTKVEVEMNGEGRILVRPSGTEPLV
N315 LSELAGQMKKYPQSLINVRVTDKYRVEENVDVKEVMTKVEVEMNGEGRILVRPSGTEPLV
NCTC8325 LSELAGQMKKYPQSLINVRVTDKYRVEENVDVKEVMTKVEVEMNGEGRILVRPSGTEPLV
Newman LSELAGQMKKYPQSLINVRVTDKYRVEENVDVKEVMTKVEVEMNGEGRILVRPSGTEPLV
USA300_FPR3757 LSELAGQMKKYPQSLINVRVTDKYRVEENVDVKEVMTKVEVEMNGEGRILVRPSGTEPLV
************************************************************
COL RVMVEAATDEDAERFAQQIADVVQDKMGLDK
N315 RVMVEAATDEDAERFAQQIADVVQDKMGLDK
NCTC8325 RVMVEAATDEDAERFAQQIADVVQDKMGLDK
Newman RVMVEAATDEDAERFAQQIADVVQDKMGLDK
USA300_FPR3757 RVMVEAATDEDAERFAQQIADVVQDKMGLDK
*******************************
- ↑ P Glanzmann, J Gustafson, H Komatsuzawa, K Ohta, B Berger-Bächi
glmM operon and methicillin-resistant glmM suppressor mutants in Staphylococcus aureus.
Antimicrob Agents Chemother: 1999, 43(2);240-5
[PubMed:9925512] [WorldCat.org] [DOI] (P p)Tommaso Tosi, Fumiya Hoshiga, Charlotte Millership, Rahul Singh, Charles Eldrid, Delphine Patin, Dominique Mengin-Lecreulx, Konstantinos Thalassinos, Paul Freemont, Angelika Gründling
Inhibition of the Staphylococcus aureus c-di-AMP cyclase DacA by direct interaction with the phosphoglucosamine mutase GlmM.
PLoS Pathog: 2019, 15(1);e1007537
[PubMed:30668586] [WorldCat.org] [DOI] (I e)Chunguang Liang, Ana B Rios-Miguel, Marcel Jarick, Priya Neurgaonkar, Myriam Girard, Patrice François, Jacques Schrenzel, Eslam S Ibrahim, Knut Ohlsen, Thomas Dandekar
Staphylococcusaureus Transcriptome Data and Metabolic Modelling Investigate the Interplay of Ser/Thr Kinase PknB, Its Phosphatase Stp, the glmR/yvcK Regulon and the cdaA Operon for Metabolic Adaptation.
Microorganisms: 2021, 9(10);
[PubMed:34683468] [WorldCat.org] [DOI] (P e)