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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005396000
- symbol?: atpA
- synonym:
- description?: F0F1 ATP synthase subunit alpha
- F0F1 ATP synthase subunit alpha
- ATP synthase subunit alpha
- ATP synthase F0F1 subunit alpha
- FOF1-ATP synthase, subunit alpha
- ATP synthase alpha chain
- ATP synthase F1, alpha subunit
- ATP synthase F1 subcomplex subunit alpha
- ATP synthase F1 subunit alpha
- ATP synthase subunit alpha, AtpA
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 5558375..5559883
- synteny block?: BlockID0041920
- occurrence?: in 100% of 34 strains
atpA : F0F1 ATP synthase subunit alpha [1]
ATP synthases couple proton translocation across membranes to rotational energy, conformational change and, ultimately, ATP generation. The F0 portion is a multimeric membrane-embedded proton channel (ab2c10) while the F1 portion is a multimeric cytoplasmic structure (α3β3γδε) that binds ADP and phosphate. When necessary, this process can also be run in reverse to generate a proton gradient at the expense of ATP. AtpA encodes F1 subunit α, the non-catalytic component of the α3β3 trimer-of-heterodimers "pinwheel". The α subunit binds nucleotide phosphates but is not catalytic; it stabilizes the catalytic β subunit and performs regulatory functions based on allosteric nucleotide phosphate binding.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2045 (atpA)
08BA02176:
C248_2119 (atpA)
11819-97:
MS7_2121 (atpA)
6850:
RSAU_001943 (atpA)
71193:
ST398NM01_2147
ECT-R 2:
ECTR2_1961 (atpA)
ED133:
SAOV_2146c (atpA)
ED98:
SAAV_2160 (atpA)
HO 5096 0412:
SAEMRSA15_20130 (atpA)
JH1:
SaurJH1_2179
JH9:
SaurJH9_2141
JKD6008:
SAA6008_02143 (atpA)
JKD6159:
SAA6159_02019 (atpA)
JSNZ:
JSNZ_002066 (atpA)
LGA251:
SARLGA251_19060 (atpA)
M013:
M013TW_2064
MRSA252:
SAR2193 (atpA)
MSHR1132:
SAMSHR1132_19280
MSSA476:
SAS2008
Mu3:
SAHV_2089 (atpA)
Mu50:
SAV2105 (atpA)
MW2:
MW2029 (atpA)
RF122:
SAB1989c (atpA)
ST398:
SAPIG2147 (atpA)
T0131:
SAT0131_02267
TCH60:
HMPREF0772_11086 (atpA)
TW20:
SATW20_22430 (atpA)
USA300_TCH1516:
USA300HOU_2095 (atpA)
VC40:
SAVC_09400
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MAIKAEEISALLRSQIENYESEMSVTDVGTVLQIGDGIALIHGLNDVMAGELVEFHNGVL
N315 MAIKAEEISALLRSQIENYESEMSVTDVGTVLQIGDGIALIHGLNDVMAGELVEFHNGVL
NCTC8325 MAIKAEEISALLRSQIENYESEMSVTDVGTVLQIGDGIALIHGLNDVMAGELVEFHNGVL
Newman MAIKAEEISALLRSQIENYESEMSVTDVGTVLQIGDGIALIHGLNDVMAGELVEFHNGVL
USA300_FPR3757 MAIKAEEISALLRSQIENYESEMSVTDVGTVLQIGDGIALIHGLNDVMAGELVEFHNGVL
************************************************************
COL GLAQNLEESNVGVVILGPYTGITEGDEVKRTGRIMEVPVGEELIGRVVNPLGQPIDGQGP
N315 GLAQNLEESNVGVVILGPYTGITEGDEVKRTGRIMEVPVGEELIGRVVNPLGQPIDGQGP
NCTC8325 GLAQNLEESNVGVVILGPYTGITEGDEVKRTGRIMEVPVGEELIGRVVNPLGQPIDGQGP
Newman GLAQNLEESNVGVVILGPYTGITEGDEVKRTGRIMEVPVGEELIGRVVNPLGQPIDGQGP
USA300_FPR3757 GLAQNLEESNVGVVILGPYTGITEGDEVKRTGRIMEVPVGEELIGRVVNPLGQPIDGQGP
************************************************************
COL INTTKTRPVEKKATGVMDRKSVDEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTTIAI
N315 INTTKTRPVEKKATGVMDRKSVDEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTTIAI
NCTC8325 INTTKTRPVEKKATGVMDRKSVDEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTTIAI
Newman INTTKTRPVEKKATGVMDRKSVDEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTTIAI
USA300_FPR3757 INTTKTRPVEKKATGVMDRKSVDEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTTIAI
************************************************************
COL DTILNQKDQGTICIYVAIGQKDSTVRANVEKLRQAGALDYTIVVAASASEPSPLLYIAPY
N315 DTILNQKDQGTICIYVAIGQKDSTVRANVEKLRQAGALDYTIVVAASASEPSPLLYIAPY
NCTC8325 DTILNQKDQGTICIYVAIGQKDSTVRANVEKLRQAGALDYTIVVAASASEPSPLLYIAPY
Newman DTILNQKDQGTICIYVAIGQKDSTVRANVEKLRQAGALDYTIVVAASASEPSPLLYIAPY
USA300_FPR3757 DTILNQKDQGTICIYVAIGQKDSTVRANVEKLRQAGALDYTIVVAASASEPSPLLYIAPY
************************************************************
COL SGVTMGEEFMFNGKHVLIVYDDLTKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLER
N315 SGVTMGEEFMFNGKHVLIVYDDLTKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLER
NCTC8325 SGVTMGEEFMFNGKHVLIVYDDLTKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLER
Newman SGVTMGEEFMFNGKHVLIVYDDLTKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLER
USA300_FPR3757 SGVTMGEEFMFNGKHVLIVYDDLTKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLER
************************************************************
COL AAKLNDDLGGGSITALPIIETQAGDISAYVPTNVISITDGQIFLQSDLFFSGVRPAINAG
N315 AAKLNDDLGGGSITALPIIETQAGDISAYVPTNVISITDGQIFLQSDLFFSGVRPAINAG
NCTC8325 AAKLNDDLGGGSITALPIIETQAGDISAYVPTNVISITDGQIFLQSDLFFSGVRPAINAG
Newman AAKLNDDLGGGSITALPIIETQAGDISAYVPTNVISITDGQIFLQSDLFFSGVRPAINAG
USA300_FPR3757 AAKLNDDLGGGSITALPIIETQAGDISAYVPTNVISITDGQIFLQSDLFFSGVRPAINAG
************************************************************
COL QSVSRVGGSAQINAMKKVAGTLRLDLASYRELESFAQFGSDLDEFTASKLERGKRTVEVL
N315 QSVSRVGGSAQIKAMKKVAGTLRLDLASYRELESFAQFGSDLDEFTASKLERGKRTVEVL
NCTC8325 QSVSRVGGSAQIKAMKKVAGTLRLDLASYRELESFAQFGSDLDEFTASKLERGKRTVEVL
Newman QSVSRVGGSAQINAMKKVAGTLRLDLASYRELESFAQFGSDLDEFTASKLERGKRTVEVL
USA300_FPR3757 QSVSRVGGSAQIKAMKKVAGTLRLDLASYRELESFAQFGSDLDEFTASKLERGKRTVEVL
************:***********************************************
COL KQDQNKPLPVEHQVLIIYALTKGYLDDIPVVDITRFEDELNHWAESNATELLNEIRETGG
N315 KQDQNKPLPVEHQVLIIYALTKGYLDDIPVVDITRFEDELNHWAESNATELLNEIRETGG
NCTC8325 KQDQNKPLPVEHQVLIIYALTKGYLDDIPVVDITRFEDELNHWAESNATELLNEIRETGG
Newman KQDQNKPLPVEHQVLIIYALTKGYLDDIPVVDITRFEDELNHWAESNATELLNEIRETGG
USA300_FPR3757 KQDQNKPLPVEHQVLIIYALTKGYLDDIPVVDITRFEDELNHWAESNATELLNEIRETGG
************************************************************
COL LPDAEKFDTAINEFKKSFSKSE
N315 LPDAEKFDTAINEFKKSFSKSE
NCTC8325 LPDAEKFDTAINEFKKSFSKSE
Newman LPDAEKFDTAINEFKKSFSKSE
USA300_FPR3757 LPDAEKFDTAINEFKKSFSKSE
**********************
- ↑ G Deckers-Hebestreit, K Altendorf
The F0F1-type ATP synthases of bacteria: structure and function of the F0 complex.
Annu Rev Microbiol: 1996, 50;791-824
[PubMed:8905099] [WorldCat.org] [DOI] (P p)Martin Vestergaard, Sahar Roshanak, Hanne Ingmer
Targeting the ATP Synthase in Staphylococcus aureus Small Colony Variants, Streptococcus pyogenes and Pathogenic Fungi.
Antibiotics (Basel): 2021, 10(4);
[PubMed:33918382] [WorldCat.org] [DOI] (P e)