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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005388000
- symbol?: murA1
- synonym:
- description?: UDP-N-acetylglucosamine 1-carboxyvinyltransferase
- UDP-N-acetylglucosamine 1-carboxyvinyltransferase
- UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
- putative UDP-N-acetylglucosamine 1-carboxyvinyltransferase
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 5552760..5554025
- synteny block?: BlockID0041840
- occurrence?: in 100% of 34 strains
murA (murA1) : UDP-N-acetylglucosamine 1-carboxyvinyltransferase [1]
MurA and MurZ can each catalyze the first committed step of cell wall synthesis - while either single-mutant is tolerated, a double-mutant is lethal. However, there are distinctions. MurZ is more resistant to fosfomycin inhibition. MurZ also appears to play a currently-undefined role alongside the dephosphorylated ReoMY system in directing MurA for ClpCP-mediated proteolysis.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2040 (murA)
08BA02176:
C248_2114 (murA1)
11819-97:
MS7_2116
6850:
RSAU_001938 (murAA)
71193:
ST398NM01_2142
ECT-R 2:
ECTR2_1956 (murA)
ED133:
SAOV_2141c
ED98:
SAAV_2155 (murAA)
HO 5096 0412:
SAEMRSA15_20080 (murA1)
JH1:
SaurJH1_2174
JH9:
SaurJH9_2136
JKD6008:
SAA6008_02138 (murA)
JKD6159:
SAA6159_02013 (murA)
JSNZ:
JSNZ_002060 (murA)
LGA251:
SARLGA251_19010 (murA1)
M013:
M013TW_2059
MRSA252:
SAR2188 (murA1)
MSHR1132:
SAMSHR1132_19230
MSSA476:
SAS2003
Mu3:
SAHV_2084 (murA)
Mu50:
SAV2099 (murA)
MW2:
MW2024 (murA)
RF122:
SAB1984c (murA1)
ST398:
SAPIG2142 (murA)
T0131:
SAT0131_02260
TCH60:
HMPREF0772_11092 (murA2)
TW20:
SATW20_22380 (murA1)
USA300_TCH1516:
USA300HOU_2090 (murA)
VC40:
SAVC_09375
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MDKIVIKGGNKLTGEVKVEGAKNAVLPILTASLLASDKPSKLVNVPALSDVETINNVLTT
N315 MDKIVIKGGNKLTGEVKVEGAKNAVLPILTASLLASDKPSKLVNVPALSDVETINNVLTT
NCTC8325 MDKIVIKGGNKLTGEVKVEGAKNAVLPILTASLLASDKPSKLVNVPALSDVETINNVLTT
Newman MDKIVIKGGNKLTGEVKVEGAKNAVLPILTASLLASDKPSKLVNVPALSDVETINNVLTT
USA300_FPR3757 MDKIVIKGGNKLTGEVKVEGAKNAVLPILTASLLASDKPSKLVNVPALSDVETINNVLTT
************************************************************
COL LNADVTYKKDENAVVVDATKTLNEEAPYEYVSKMRASILVMGPLLARLGHAIVALPGGCA
N315 LNADVTYKKDENAVVVDATKTLNEEAPYEYVSKMRASILVMGPLLARLGHAIVALPGGCA
NCTC8325 LNADVTYKKDENAVVVDATKTLNEEAPYEYVSKMRASILVMGPLLARLGHAIVALPGGCA
Newman LNADVTYKKDENAVVVDATKTLNEEAPYEYVSKMRASILVMGPLLARLGHAIVALPGGCA
USA300_FPR3757 LNADVTYKKDENAVVVDATKTLNEEAPYEYVSKMRASILVMGPLLARLGHAIVALPGGCA
************************************************************
COL IGSRPIEQHIKGFEALGAEIHLENGNIYANAKDGLKGTSIHLDFPSVGATQNIIMAASLA
N315 IGSRPIEQHIKGFEALGAEIHLENGNIYANAKDGLKGTSIHLDFPSVGATQNIIMAASLA
NCTC8325 IGSRPIEQHIKGFEALGAEIHLENGNIYANAKDGLKGTSIHLDFPSVGATQNIIMAASLA
Newman IGSRPIEQHIKGFEALGAEIHLENGNIYANAKDGLKGTSIHLDFPSVGATQNIIMAASLA
USA300_FPR3757 IGSRPIEQHIKGFEALGAEIHLENGNIYANAKDGLKGTSIHLDFPSVGATQNIIMAASLA
************************************************************
COL KGKTLIENAAKEPEIVDLANYINEMGGRITGAGTDTITINGVESLHGVEHAIIPDRIEAG
N315 KGKTLIENAAKEPEIVDLANYINEMGGRITGAGTDTITINGVESLHGVEHAIIPDRIEAG
NCTC8325 KGKTLIENAAKEPEIVDLANYINEMGGRITGAGTDTITINGVESLHGVEHAIIPDRIEAG
Newman KGKTLIENAAKEPEIVDLANYINEMGGRITGAGTDTITINGVESLHGVEHAIIPDRIEAG
USA300_FPR3757 KGKTLIENAAKEPEIVDLANYINEMGGRITGAGTDTITINGVESLHGVEHAIIPDRIEAG
************************************************************
COL TLLIAGAITRGDIFVRGAIKEHMASLVYKLEEMGVELDYQEDGIRVRAEGELQPVDIKTL
N315 TLLIAGAITRGDIFVRGAIKEHMASLVYKLEEMGVELDYQEDGIRVRAEGELQPVDIKTL
NCTC8325 TLLIAGAITRGDIFVRGAIKEHMASLVYKLEEMGVELDYQEDGIRVRAEGELQPVDIKTL
Newman TLLIAGAITRGDIFVRGAIKEHMASLVYKLEEMGVELDYQEDGIRVRAEGELQPVDIKTL
USA300_FPR3757 TLLIAGAITRGDIFVRDAIKEHMASLVYKLEEMGVELDYQEDGIRVRAEGELQPVDIKTL
****************.*******************************************
COL PHPGFPTDMQSQMMALLLTANGHKVVTETVFENRFMHVAEFKRMNANINVEGRSAKLEGK
N315 PHPGFPTDMQSQMMALLLTANGHKVVTETVFENRFMHVAEFKRMNANINVEGRSAKLEGK
NCTC8325 PHPGFPTDMQSQMMALLLTANGHKVVTETVFENRFMHVAEFKRMNANINVEGRSAKLEGK
Newman PHPGFPTDMQSQMMALLLTANGHKVVTETVFENRFMHVAEFKRMNANINVEGRSAKLEGK
USA300_FPR3757 PHPGFPTDMQSQMMALLLTANGHKVVTETVFENRFMHVAEFKRMNANINVEGRSAKLEGK
************************************************************
COL SQLQGAQVKATDLRAAAALILAGLVADGKTSVTELTHLDRGYVDLHGKLKQLGADIERIN
N315 SQLQGAQVKATDLRAAAALILAGLVADGKTSVTELTHLDRGYVDLHGKLKQLGADIERIN
NCTC8325 SQLQGAQVKATDLRAAAALILAGLVADGKTSVTELTHLDRGYVDLHGKLKQLGADIERIN
Newman SQLQGAQVKATDLRAAAALILAGLVADGKTSVTELTHLDRGYVDLHGKLKQLGADIERIN
USA300_FPR3757 SQLQGAQVKATDLRAAAALILAGLVADGKTSVTELTHLDRGYVDLHGKLKQLGADIERIN
************************************************************
COL D
N315 D
NCTC8325 D
Newman D
USA300_FPR3757 D
*
- ↑ Katy L Blake, Alex J O'Neill, Dominique Mengin-Lecreulx, Peter J F Henderson, Julieanne M Bostock, Colin J Dunsmore, Katie J Simmons, Colin W G Fishwick, Jennifer A Leeds, Ian Chopra
The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors.
Mol Microbiol: 2009, 72(2);335-43
[PubMed:19298367] [WorldCat.org] [DOI] (I p)Thomas Böttcher, Stephan A Sieber
Showdomycin as a versatile chemical tool for the detection of pathogenesis-associated enzymes in bacteria.
J Am Chem Soc: 2010, 132(20);6964-72
[PubMed:20433172] [WorldCat.org] [DOI] (I p)Soma Ghosh, Jyoti Prava, Himanshu Bhusan Samal, Mrutyunjay Suar, Rajani Kanta Mahapatra
Comparative genomics study for the identification of drug and vaccine targets in Staphylococcus aureus: MurA ligase enzyme as a proposed candidate.
J Microbiol Methods: 2014, 101;1-8
[PubMed:24685600] [WorldCat.org] [DOI] (I p)