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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005018000
- symbol?: scn
- synonym:
- description?: complement inhibitor SCIN
- complement inhibitor SCIN
- complement inhibitor SCIN-A
- staphylococcal complement inhibitor SCIN
- Involved in expression of fibrinogen binding protein, phage associated
- Staphylococcal complement inhibitor
- staphylococcal complement inhibitor (SCIN)
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 5192645..5193726
- synteny block?: BlockID0038990
- occurrence?: in 65% of 34 strains
scn : prophage-encoded complement inhibitor SCIN-A [1]
• A crystal structure is available : 3OHX
Complement inhibitor SCIN-A is a component of the immune evasion module found on hlb-converting prophage that is a major contributor to human pathogenic potential. SCIN-A specifically inhibits C3 convertase, preventing complement cascade activation.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1901
08BA02176:
—
11819-97:
MS7_1977
6850:
RSAU_000620 (scn)
71193:
ST398NM01_0482
ECT-R 2:
ECTR2_1814
ED133:
—
ED98:
—
HO 5096 0412:
SAEMRSA15_18580
JH1:
SaurJH1_2034
JH9:
SaurJH9_1999
JKD6008:
SAA6008_01955 (scn)
JKD6159:
—
JSNZ:
—
LGA251:
—
M013:
—
MRSA252:
SAR2035
MSHR1132:
—
MSSA476:
SAS1866
Mu3:
SAHV_1927
Mu50:
SAV1942
MW2:
MW1884
RF122:
—
ST398:
—
T0131:
SAT0131_02076
TCH60:
HMPREF0772_11198
TW20:
SATW20_19360 (scn)
USA300_TCH1516:
USA300HOU_1946
VC40:
—
⊟Genome Viewer[edit | edit source]
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
N315 MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSLPTSNEYQNEKLANELKSLLDELNVN
NCTC8325 MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSLPTSNEYQNEKLANELKSLLDELNVN
Newman MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSLPTSNEYQNEKLANELKSLLDELNVN
USA300_FPR3757 MKIRKSILAGTLAIVLASPLVTNLDKNEAQASTSLPTSNEYQNEKLANELKSLLDELNVN
************************************************************
N315 ELATGSLNTYYKRTIKISGLKAMYALKSKDFKKMSEAKYQLQKIYNEIDEALKSKY
NCTC8325 ELATGSLNTYYKRTIKISGLKAMYALKSKDFKKMSEAKYQLQKIYNEIDEALKSKY
Newman ELATGSLNTYYKRTIKISGQKAMYALKSKDFKKMSEAKYQLQKIYNEIDEALKSKY
USA300_FPR3757 ELATGSLNTYYKRTIKISGQKAMYALKSKDFKKMSEAKYQLQKIYNEIDEALKSKY
******************* ************************************
- ↑ Brandon L Garcia, Kasra X Ramyar, Daniel Ricklin, John D Lambris, Brian V Geisbrecht
Advances in understanding the structure, function, and mechanism of the SCIN and Efb families of Staphylococcal immune evasion proteins.
Adv Exp Med Biol: 2012, 946;113-33
[PubMed:21948365] [WorldCat.org] [DOI] (P p)Andi R Sultan, Jasper W Swierstra, Nicole A Lemmens-den Toom, Susan V Snijders, Silvie Hansenová Maňásková, Annelies Verbon, Willem J B van Wamel
Production of Staphylococcal Complement Inhibitor (SCIN) and Other Immune Modulators during the Early Stages of Staphylococcus aureus Biofilm Formation in a Mammalian Cell Culture Medium.
Infect Immun: 2018, 86(8);
[PubMed:29784858] [WorldCat.org] [DOI] (I e)Chrispin Chaguza, Joshua T Smith, Spencer A Bruce, Robert Gibson, Isabella W Martin, Cheryl P Andam
Prophage-encoded immune evasion factors are critical for Staphylococcus aureus host infection, switching, and adaptation.
Cell Genom: 2022, 2(11);
[PubMed:36465278] [WorldCat.org] [DOI] (I p)