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⊟Summary[edit | edit source]
- pan ID?: SAUPAN004407000
- symbol?: murC
- synonym:
- description?: UDP-N-acetylmuramate--L-alanine ligase
- UDP-N-acetylmuramate--L-alanine ligase
- UDP-N-acetylmuramate--alanine ligase
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4649011..4650249
- synteny block?: BlockID0034110
- occurrence?: in 100% of 34 strains
murC : UDP-N-acetylmuramate:L-alanine ligase [1]
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1698 (murC)
08BA02176:
C248_1785 (murC)
11819-97:
MS7_1746 (murC)
6850:
RSAU_001597 (murC)
71193:
ST398NM01_1793
ECT-R 2:
ECTR2_1580 (murC)
ED133:
SAOV_1726 (murC)
ED98:
SAAV_1750 (murC)
HO 5096 0412:
SAEMRSA15_16480 (murC)
JH1:
SaurJH1_1830 (murC)
JH9:
SaurJH9_1795 (murC)
JKD6008:
SAA6008_01711 (murC)
JKD6159:
SAA6159_01663 (murC)
JSNZ:
JSNZ_001730 (murC)
LGA251:
SARLGA251_16300 (murC)
M013:
M013TW_1754
MRSA252:
SAR1818 (murC)
MSHR1132:
SAMSHR1132_15900
MSSA476:
SAS1666 (murC)
Mu3:
SAHV_1726 (murC)
Mu50:
SAV1740 (murC)
MW2:
MW1683 (murC)
RF122:
SAB1600c (murC)
ST398:
SAPIG1793 (murC)
T0131:
SAT0131_01848
TCH60:
HMPREF0772_11413 (murC)
TW20:
SATW20_17300 (murC)
USA300_TCH1516:
USA300HOU_1730 (murC)
VC40:
SAVC_07910 (murC)
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MTHYHFVGIKGSGMSSLAQIMHDLGHEVQGSDIENYVFTEVALRNKGIKILPFDANNIKE
N315 MTHYHFVGIKGSGMSSLAQIMHDLGHEVQGSDIENYVFTEVALRNKGIKILPFDANNIKE
NCTC8325 MTHYHFVGIKGSGMSSLAQIMHDLGHEVQGSDIENYVFTEVALRNKGIKILPFDANNIKE
Newman MTHYHFVGIKGSGMSSLAQIMHDLGHEVQGSDIENYVFTEVALRNKGIKILPFDANNIKE
USA300_FPR3757 MTHYHFVGIKGSGMSSLAQIMHDLGHEVQGSDIENYVFTEVALRNKGIKILPFDANNIKE
************************************************************
COL DMVVIQGNAFASSHEEIVRAHQLKLDVVSYNDFLGQIIDQYTSVAVTGAHGKTSTTGLLS
N315 DMVVIQGNAFASSHEEIVRAHQLKLDVVSYNDFLGQIIDQYTSVAVTGAHGKTSTTGLLS
NCTC8325 DMVVIQGNAFASSHEEIVRAHQLKLDVVSYNDFLGQIIDQYTSVAVTGAHGKTSTTGLLS
Newman DMVVIQGNAFASSHEEIVRAHQLKLDVVSYNDFLGQIIDQYTSVAVTGAHGKTSTTGLLS
USA300_FPR3757 DMVVIQGNAFASSHEEIVRAHQLKLDVVSYNDFLGQIIDQYTSVAVTGAHGKTSTTGLLS
************************************************************
COL HVMNGDKKTSFLIGDGTGMGLPESDYFAFEACEYRRHFLSYKPDYAIMTNIDFDHPDYFK
N315 HVMNGDKKTSFLIGDGTGMGLPESDYFAFEACEYRRHFLSYKPDYAIMTNIDFDHPDYFK
NCTC8325 HVMNGDKKTSFLIGDGTGMGLPESDYFAFEACEYRRHFLSYKPDYAIMTNIDFDHPDYFK
Newman HVMNGDKKTSFLIGDGTGMGLPESDYFAFEACEYRRHFLSYKPDYAIMTNIDFDHPDYFK
USA300_FPR3757 HVMNGDKKTSFLIGDGTGMGLPESDYFAFEACEYRRHFLSYKPDYAIMTNIDFDHPDYFK
************************************************************
COL DINDVFDAFQEMAHNVKKGIIAWGDDEHLRKIEADVPIYYYGFKDSDDIYAQNIQITDKG
N315 DINDVFDAFQEMAHNVKKGIIAWGDDEHLRKIEADVPIYYYGFKDSDDIYAQNIQITDKG
NCTC8325 DINDVFDAFQEMAHNVKKGIIAWGDDEHLRKIEADVPIYYYGFKDSDDIYAQNIQITDKG
Newman DINDVFDAFQEMAHNVKKGIIAWGDDEHLRKIEADVPIYYYGFKDSDDIYAQNIQITDKG
USA300_FPR3757 DINDVFDAFQEMAHNVKKGIIAWGDDEHLRKIEADVPIYYYGFKDSDDIYAQNIQITDKG
************************************************************
COL TAFDVYVDGEFYDHFLSPQYGDHTVLNALAVIAISYLEKLDVTNIKEALETFGGVKRRFN
N315 TAFDVYVDGEFYDHFLSPQYGDHTVLNALAVIAISYLEKLDVTNIKEALETFGGVKRRFN
NCTC8325 TAFDVYVDGEFYDHFLSPQYGDHTVLNALAVIAISYLEKLDVTNIKEALETFGGVKRRFN
Newman TAFDVYVDGEFYDHFLSPQYGDHTVLNALAVIAISYLEKLDVTNIKEALETFGGVKRRFN
USA300_FPR3757 TAFDVYVDGEFYDHFLSPQYGDHTVLNALAVIAISYLEKLDVTNIKEALETFGGVKRRFN
************************************************************
COL ETTIANQVIVDDYAHHPREISATIETARKKYPHKEVVAVFQPHTFSRTQAFLNEFAESLS
N315 ETTIANQVIVDDYAHHPREISATIETARKKYPHKEVVAVFQPHTFSRTQAFLNEFAESLS
NCTC8325 ETTIANQVIVDDYAHHPREISATIETARKKYPHKEVVAVFQPHTFSRTQAFLNEFAESLS
Newman ETTIANQVIVDDYAHHPREISATIETARKKYPHKEVVAVFQPHTFSRTQAFLNEFAESLS
USA300_FPR3757 ETTIANQVIVDDYAHHPREISATIETARKKYPHKEVVAVFQPHTFSRTQAFLNEFAESLS
************************************************************
COL KADRVFLCEIFGSIRENTGALTIQDLIDKIEGASLINEDSINVLEQFDNAVILFMGAGDI
N315 KADRVFLCEIFGSIRENTGALTIQDLIDKIEGASLINEDSINVLEQFDNAVVLFMGAGDI
NCTC8325 KADRVFLCEIFGSIRENTGALTIQDLIDKIEGASLINEDSINVLEQFDNAVILFMGAGDI
Newman KADRVFLCEIFGSIRENTGALTIQDLIDKIEGASLINEDSINVLEQFDNAVILFMGAGDI
USA300_FPR3757 KADRVFLCEIFGSIRENTGALTIQDLIDKIEGASLINEDSINVLEQFDNAVILFMGAGDI
***************************************************:********
COL QKLQNAYLDKLGMKNAF
N315 QKLQNAYLDKLGMKNAF
NCTC8325 QKLQNAYLDKLGMKNAF
Newman QKLQNAYLDKLGMKNAF
USA300_FPR3757 QKLQNAYLDKLGMKNAF
*****************
- ↑ A M Lowe, R L Deresiewicz
Cloning and sequencing of Staphylococcus aureus murC, a gene essential for cell wall biosynthesis.
DNA Seq: 1999, 10(1);19-23
[PubMed:10565540] [WorldCat.org] [DOI] (P p)Mihoko Ishibashi, Kenji Kurokawa, Satoshi Nishida, Kohji Ueno, Miki Matsuo, Kazuhisa Sekimizu
Isolation of temperature-sensitive mutations in murC of Staphylococcus aureus.
FEMS Microbiol Lett: 2007, 274(2);204-9
[PubMed:17608695] [WorldCat.org] [DOI] (P p)Kenji Kurokawa, Satoshi Nishida, Mihoko Ishibashi, Hikaru Mizumura, Kohji Ueno, Takashi Yutsudo, Hideki Maki, Kazuhisa Murakami, Kazuhisa Sekimizu
Staphylococcus aureus MurC participates in L-alanine recognition via histidine 343, a conserved motif in the shallow hydrophobic pocket.
J Biochem: 2008, 143(3);417-24
[PubMed:18084043] [WorldCat.org] [DOI] (P p)Delphine Patin, Audrey Boniface, Andreja Kovač, Mireille Hervé, Sébastien Dementin, Hélène Barreteau, Dominique Mengin-Lecreulx, Didier Blanot
Purification and biochemical characterization of Mur ligases from Staphylococcus aureus.
Biochimie: 2010, 92(12);1793-800
[PubMed:20659527] [WorldCat.org] [DOI] (I p)